Birinapant

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1 Gram	Negotiable

1 Gram

Negotiable

Min.Order :1 Gram
Purity: 98% purity
Payment Terms : T/T,,MoneyGram,Other

Keywords

Birinapant 1260251-31-7 98% purity

Quick Details

Appearance:powder
Application:intermediate
PackAge:accroding to the need
ProductionCapacity:100|Kilogram|Day
Storage:Sealed in dry,Room Temperature
Transportation:air，sea and courier

Superiority:

Product Name:   Birinapant
Synonyms:   Birinapant;Birinapant (TL32711);TL 32711;Birinapant(TL32711)/TL-32711/TL32711/TL-32711;(2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-propanamide;Propanamide, N,N'-[(6,6'-difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-, (2S,2'S)-;(2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-propanamide Birinapant TL 32711;Birinapant (2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-propanamide
CAS:   1260251-31-7
MF:   C42H56F2N8O6
MW:   806.94
Mol File:   1260251-31-7.mol

Details:

Birinapant Chemical Properties
Boiling point    1090.5±65.0 °C(Predicted)
density    1.320±0.06(20.0000℃)
pka   13.99±0.46(Predicted)
CAS DataBase Reference   1260251-31-7
Safety Information
HS Code    29339900
MSDS Information
Birinapant Usage And Synthesis
Enzyme inhibitor   This rotationally symmetric SMAC mimetic antagonist and anticancer agent (FW = 806.94 g/mol; CAS 1260251-31-7) targets cellular Inhibitor of Apoptosis Protein (or cIAP1; Kd of <1 nM), arguably the most potent mammalian caspase inhibitor, showing single-agent efficacy due to its panIAP antagonism and causing rapid cIAP1 degradation, caspase activation, PARP cleavage, and NF-κB activation. When administered in combination with TNF-α, Birinapant is effective against a melanoma cell line with acquired resistance to BRAF inhibitors

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