RG108

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1 Gram	Negotiable

1 Gram

Negotiable

Min.Order :1 Gram
Purity: 99% purity
Payment Terms : T/T,,MoneyGram,Other

Keywords

RG108 48208-26-0 99% purity

Quick Details

Appearance:powder
Application:intermediate
PackAge:accroding to the need
ProductionCapacity:100|Kilogram|Day
Storage:Sealed in dry,Room Temperature
Transportation:air，sea and courier

Superiority:

Product Name:   RG108
Synonyms:   (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid;RG108/RG-108;(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;N-Phthaloyl-L-tryptophan;1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)-;N-Phthaloyl-L-tryptophan (S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;CS-1518;DNA Methyltransferase Inhibitor
CAS:   48208-26-0
MF:   C19H14N2O4
MW:   334.33
Mol File:   48208-26-0.mol

Details:

Melting point    192-194℃
Boiling point    606.0±50.0 °C(Predicted)
density    1.502±0.06 g/cm3(Predicted)
storage temp.    -20°C
solubility    DMSO: >10mg/mL
pka   3.62±0.10(Predicted)
form    powder
color    yellow
Sensitive    Light Sensitive
CAS DataBase Reference   48208-26-0
Safety Information
WGK Germany    3
MSDS Information
RG108 Usage And Synthesis
Uses   DNA methylation regulates gene expression in normal and malignant cells. RG-108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro). It significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Further, RG-108 inhibits DNA methyltransferase activity by blocking the enzyme active site. Through these actions, RG-108 demethylates and reactivates epigenetically silenced tumor suppressor genes.
Biological Activity   Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes.