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C26H34O7 CAS1108-68-5 Factory direct sale
Cinobutanin is a total indole alkaloid extracted from the dried toad skin of bufo bufo, which has the functions of clearing heat and detoxifying, reducing swelling and relieving pain, promoting blood circulation and removing stasis, and softening firm and dispersive knot. Animal experiments have shown that cinobutanin can improve the immune capacity of the body and inhibit the synthesis of DNA and RNA in tumor cells.
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Pharmacological action :
1. Antitumor action. The crude drug Of cinobufalin 3G (per kg body weight) had obvious tumor suppressive effect on S180 sarcoma and H22 liver cancer in mice, and had obvious life prolonging tendency on L1210 leukemia mice. The inhibition rate of 7.5g crude drug /kg of cinobutanin on W256 in rats was 68.7%. In vitro drug experiments showed that the crude drug 2mg/ml of cinobufalin had cytotoxic effects on three tumor strains of digestive system (human liver cancer SMMC-7721, human gastric cancer MKN45 and human colon cancer LOVO), and its mechanism was to directly kill tumor cell DNA and lead to tumor cell necrosis. From the molecular level, it was observed that cinbulitin could increase the plasma cAMP content and restore the normal cAMP/cGMP ratio in H22 hepatocellular carcinoma mice. The inhibition rate was 35.5% when used alone in mice with S180 sarcoma, and increased to 71% when combined with CTX chemicalbook. The efficacy was better than that of CTX alone, indicating that the combined use of CTX and Cinefadin had a synergistic effect. Clinical data also showed that the combination of cinobufalin with 5-FU, CTX, MTX and VCR had a synergistic effect, and the efficacy of chemotherapy combined with cinobufalin was significantly higher than that of chemotherapy alone, and the toxic and side effects of radiotherapy and chemotherapy could be alleviated.
2. Immune promotion. It can prevent and cure leukopenia caused by CTX, increase the ratio of lymphocyte, and increase the content of IgG and IgM in serum of mice. The experimental data also showed that cinobutanin could enhance humoral immunity and cellular immunity.
3, antiviral effect. The results showed that huafinin inhibited the replication of both 2215 cells and duck HEPATITIS B virus. Clinical data also showed that huafinin had a significant effect on chronic HBsAg carriers.
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Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
6. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
7. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
8. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
9. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
10. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.
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