4-Chloro-4'-hydroxybenzophenone

Details:

Melting point     177-181 °C
Boiling point     257 °C (13 mmHg)
density     1.2082 (rough estimate)
refractive index     1.5434 (estimate)
Fp     100 °C
storage temp.     Inert atmosphere,Room Temperature
pka    7.68±0.15(Predicted)
form     neat
BRN     2049956
CAS DataBase Reference    42019-78-3(CAS DataBase Reference)
NIST Chemistry Reference    Methanone, (4-chlorophenyl)(4-hydroxyphenyl)-(42019-78-3)
Safety Information
Hazard Codes     Xi,Xn
Risk Statements     36/37/38-20/21/22
Safety Statements     24/25-37/39-26-36
Hazard Note     Irritant
HS Code     29144000
MSDS Information
Provider    Language
(4-Chlorophenyl)(4-hydroxyphenyl)-Methanone    English
ACROS    English
ALFA    English
4-Chloro-4'-hydroxybenzophenone Usage And Synthesis
Chemical Properties    light grey to beige-brown powder
Uses    The Impurity of Fenofibric acid (42017-89-0), the active metabolite of fenofibrate which increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptor
Preparation    Preparation by Fries rearrangement of phenyl p-chloro-benzoate,
in the presence of aluminium chloride, without solvent, at 160° for 5 min, between 120° and 160° (good yield) or at 130° for 1 h, then at 160° for 1 h (10%) or in refluxing chlorobenzene for 10 h (52%);
in the presence of trifluoromethanesulfonic acid at 45–55° (94%).
4-Chloro-4'-hydroxybenzophenone Preparation Products And Raw materials
Raw materials    Aluminum chloride-->Anisole-->4-Chlorobenzoyl chloride-->4-Chlorophenylacetylene-->4-chloro-4'-methoxybenzophenone-->SYN-BENZALDEHYDE OXIME-->4-chloro-4'-fluorobenzophenone-->4-CHLORO-4'-NITROBENZOPHENONE
Preparation Products    Fenofibric acid