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Best Quality Fast Delivery Croscarmellose Sodium CAS 74811-65-7 with low price

Best Quality Fast Delivery Croscarmellose Sodium CAS 74811-65-7 with low price

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: >99%
  • Payment Terms : L/C,T/T,Other

Keywords

Croscarmellose Sodium sodium croscarmellose 74811-65-7

Quick Details

  • Appearance:white Powder
  • Application:tablet and capsule disintegrant
  • PackAge:1-5KG/Tin or Bag,25KG/Drum, 200KG/Drum
  • ProductionCapacity:1000 |Metric Ton|Year
  • Storage:Cool Dry Place
  • Transportation:by sea or by air

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Details:

Product information

Croscarmellose sodium, or sodium CMC CAS:74811-65-7, is a cross-linked polymer of carboxymethylcellulose sodium. It appears as white, fibrous, free-flowing powder. Without a disintegrant, tablets may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness. Caroxymethylcellulose sodium is generally regarded as safe when used in normal quantities.
Croscarmellose Sodium CAS: 74811-65-7 has a molecular formula of C8H9NaO7 and a molecular weight of 241.03200.

Application
Croscarmellose sodium is used in oral pharmaceutical formulations as a disintegrant for capsules,tablets, and granules.
In tablet formulations, croscarmellose sodium may be used in bothdirect-compressionandwet-granulationprocesses.Whenused in wet granulations, the croscarmellose sodium should be added in both the wet and dry stages of the process (intra- and extragranularly) so that the wicking and swelling ability of the disintegrant is best utilized. Croscarmellose sodium at concentrations up to 5% w/w may be used as a tablet disintegrant, although normally 2% w/w is used in tablets prepared by direct compression and 3% w/w in tablets prepared by a wet-granulation process.

Specification

Items Standard USP35/EP7.0/BP2013 Result
Characters A White free flowing powder,odorless. Complies
Identification A;B;C To meet requirement Conforms
PH 5.0-7.0 6.6
Loss on Drying % Not more than 10.0 2.6
Na-chloride&Na-glycolate % Not more than 0.50 0.16
Heavy metals (ppm) Not more than 10 Conforms
Degree of Substitution 0.60-0.85 0.71
Water-soluble substances (%) Not more than 10.0 8.1
Settling volume 20-30 20.15
Retained 200 mesh(74Microns) Not more than10.0 1.5
Residue on ignition 14.0-28.0 15
Solubility Complies Conforms
Total aerobic microbial count Complies Conforms
Total molds and yeasts count Complies Conforms
Escherichia coli Absence Conforms
Conclusion:The product conforms to above test of [USP35/EP7.0/BP2013].


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