2-Pyrazinecarboxylic acid

Details:

Melting point     222-225 °C (dec.)(lit.)
Boiling point     230.85°C (rough estimate)
density     1.4317 (rough estimate)
refractive index     1.4800 (estimate)
storage temp.     Keep in dark place,Sealed in dry,Room Temperature
form     Crystalline Powder
pka    pK (25°) 2.92
color     White to off-white
Water Solubility     SOLUBLE IN COLD WATER
Merck     14,8970
BRN     112305
InChIKey    NIPZZXUFJPQHNH-UHFFFAOYSA-N
CAS DataBase Reference    98-97-5(CAS DataBase Reference)
NIST Chemistry Reference    Pyrazinoic acid(98-97-5)
Safety Information
Hazard Codes     Xi,C,F
Risk Statements     11-34
Safety Statements     22-24/25-45-36/37/39-26-16
WGK Germany     3
HS Code     29339990
MSDS Information
Provider    Language
2-Pyrazinecarboxylic acid    English
ACROS    English
SigmaAldrich    English
ALFA    English
2-Pyrazinecarboxylic acid Usage And Synthesis
Chemical Properties    WHITE TO OFF-WHITE CRYSTALLINE POWDER
Uses    Pyrazinecarboxylic Acid is a very potent urate retaining drug. Pyrazinecarboxylic Acid is a metabolite of the antibacterial agent Pyrazinamide (P840600).
Uses    Labelled analogue of Pyrazinecarboxylic Acid, a very potent urate retaining drug. Pyrazinecarboxylic Acid is a metabolite of the antibacterial agent Pyrazinamide (P840600).
Definition    ChEBI: The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide.
Synthesis Reference(s)    The Journal of Organic Chemistry, 40, p. 1187, 1975 DOI: 10.1021/jo00896a050
Purification Methods    It crystallises from water. The methyl ester has m 62o (from pet ether). [Sauville & Spoerri J Am Chem Soc 63 3153 1941, Beilstein 25 III/IV 771.]
2-Pyrazinecarboxylic acid Preparation Products And Raw materials
Raw materials    2,3-Pyrazinedicarboxylic acid-->5-Methyl-2-pyrazinecarboxylic acid
Preparation Products    3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER-->PIPERAZINE-2-CARBOXYLIC ACID-->(R)-PIPERAZINE-2-CARBOXYLIC ACID-->METHYL 2-CHLORO-6-PYRAZINECARBOXYLATE-->2-PYRAZINECARBONYL CHLORIDE-->(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID-->METHYL 4-BOC-PIPERAZINE-2-CARBOXYLATE