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monensin Monensin A 17090-79-8
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Product information
Product Name: | Monensin |
CAS: | 17090-79-8 |
MF: | C36H62O11 |
MW: | 670.87 |
EINECS: | 241-154-0 |
Mol File: | 17090-79-8.mol |
Monensin anticoccidiostat with wide spectrum belongs to ployether antibiotic, and is one of most typical veterinary of
anticoccidiostat that is first used and most marketable in the world. Gram-positive and fungus on vegetable are sensitive to it.
It can inhibits coccid's growth and finally kill it, especially to eimeria tenella coccidial.
Application
Monensin A is a polyether antibiotic first isolated from Streptomyces cinnamonensis in 1967. Monensin A is a broad-spectrum anticoccicidial antibiotic, also exhibiting antifungal and antiviral activity. Monensin A forms complexes with monovalent cations such as Li+, Na+, K+, Rb+, Ag+ and Tl+ and is thus able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport and is used in animals to prevent coccidiosis, promote growth and prevent bloat. Derivatives of monensin, monensin methyl ester and particularly monensin decyl ester, are used in ion selective electrodes.
Monensin (2) C36H62O11, a carboxylic acid which is used as its water-soluble sodium salt (Coban, Rumensin). Monensin is also used to treat histomoniasis. The polyether ionophoric antibiotics are capable of complexing and interfacing with specific alkali metal cations to render them lipid-soluble and diffusible across parasite mitochondrial membranes. Related useful polyether antibiotics are narasin and lasalocid (3, Lasalocid A, C34H54O8,).
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