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Ondansetron HCl Hydrochloride factory price High purity 99%
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Product Information
Product Name: Ondansetron hydrochloride
Synonyms: ONDANSETRON HYDROCHLORIDE HYDRATE;9-METHYL-3-[(2-METHYLIMIDAZOL-1-YL)METHYL]-2,3-DIHYDRO-1H-CARBAZOL-4-ONE;AKOS NCG1-0013;GR 38032;SN 307;NSC 665799;(99614-01-4) ondansetron hydrochloride;OndansetronHclUsp28;OndansetronHClmonohydrate;Ondansetronhydrochloridemonohydrate
CAS: 103639-04-9
MF: C18H19N3O·HCl·2H2O
MW: 365.85
EINECS: 600-465-5
Melting point: 231-232°C
Storage temp.: −20°C
Description:
Ondansetron hydrochloride is a selective 5HT3-antagonist approved for the management of nausea and vomiting induced by cancer chemotherapy and radiotherapy. It is reported to have a superior side-effect profile compared with metoclopramide, representing an important advance in the treatment of nausea and vomiting associated with chemotherapy. Ondansetron hydrochloride is the first specific 5HT3-antagonist to reach the market. It is also under investigation for a number of other indications, including anxiety and schizophrenia.
Usage
Antiemetic;Serotonergic receptor antagonist
COA
Items | Specifications | Results |
Appearance | White or off-white crystalline powder | Qualified |
Solubility | Sparingly soluble in water and in alcohol, slightly soluble in isopropyl very slightly |
Qualified |
Identification | ||
1.UV | Max 209,248,267,310nm | Qualified |
2.IR spectrum | Concordant with the working reference. | Qualified |
3.Discrimination chloride | Forward Reaction . | Qualified |
Water | 9.0-10.5% | 9.7% |
Residue on Ignition | ≤0.1% | 0.02% |
Heavy metal | ≤10ppm | <10ppm |
Compound D | ≤0.1% | 0.04% |
Chromatographic purity | ||
TLC max single impurity | ≤0.40% | 0.11% |
Other single impurity | ≤0.20% | 0.09% |
HPLC Impurity C | ≤0.20% | 0.09% |
Imidazole | ≤0.20% | 0.02% |
2-methylimidazole | ≤0.20% | 0.02% |
-Impurity A | ≤0.20% | 0.05% |
-Other single impurity | ≤0.10% | 0.07% |
-Total Impurity | ≤0.50% | 0.29% |
Residual solvent | ||
Ethanol | ≤5000ppm | 240ppm |
Assay | 98.0%~102.0% Calculates on the dried basis. |
99.81% |
CONCLUSION: CONFORM WITH SPECIFICATION AS PER USP40. |
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