1-Acetyl-4-piperidinecarboxylic acid

Details:

1-Acetyl-4-piperidinecarboxylic acid Chemical Properties
Melting point     180-184 °C (lit.)
Boiling point     301.17°C (rough estimate)
density     1.1998 (rough estimate)
refractive index     1.4750 (estimate)
storage temp.     Sealed in dry,Room Temperature
form     Crystalline Powder
pka    4.35±0.20(Predicted)
color     White to beige
Water Solubility     50 g/L (20 ºC)
BRN     389577
CAS DataBase Reference    25503-90-6(CAS DataBase Reference)
NIST Chemistry Reference    1-Acetyl-4-piperidinecarboxylic acid(25503-90-6)
Safety Information
Hazard Codes     Xn,Xi
Risk Statements     22-36/37/38-43
Safety Statements     26-36-37/39
WGK Germany     2
Hazard Note     Irritant
HazardClass     IRRITANT
HS Code     29339900
MSDS Information
Provider    Language
1-Acetylpiperidine-4-carboxylic acid    English
SigmaAldrich    English
ACROS    English
ALFA    English
1-Acetyl-4-piperidinecarboxylic acid Usage And Synthesis
Chemical Properties    White Crystalline Solid
Uses    A synthetic intermediate in the preparation of CNS depressants
Uses    Reactant for synthesis of:• ;Triazole derivatives1• ;Antiproliferative agents2• ;CDK inhibitors3• ;CCR5 antagonists for HIV treatment4• ;nhNK1 antagonists5• ;Piperidine derivatives6
Uses    Metabolite fingerprinting in transgenic Nicotiana tabacum altered by the Escherichia coli glutamate dehydrogenase gene.
1-Acetyl-4-piperidinecarboxylic acid Preparation Products And Raw materials
Raw materials    Acetic anhydride-->Isopropyl alcohol-->Isopropyl ether-->Isonipecotic acid
Preparation Products    1-[4-(2,4-DIFLUORO-BENZOYL)-PIPERIDIN-1-YL]-ETHANONE-->4-BENZOYLPIPERIDINE HYDROCHLORIDE-->4-BENZOYLPIPERIDINE HYDROCHLORIDE