Molnupiravir(EIDD-2801) CAS: 2349386-89-4

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【 Product Description 】

 

 

Eidd-2801 is an oral bioavailable prodrug of the riboside analogue EIDD-1931. Eidd-2801 has broad spectrum antiviral activity against influenza viruses and multiple coronaviruses such as SARS-COV-2, MERS-CoV, and SARS-COV. Eidd-2801 has the potential to treat COVID-19 as well as seasonal and pandemic influenza.

 

【 Monabillaway 】

 

Molnupiravir, also known as EIDD-2801/MK4482, is a riboside analogue that inhibits replication of a variety of RNA viruses, including SARS-COV-2. Eidd-2801 is the oral form of the antiviral compound EIDD-1931; It can be taken as a pill and can be properly absorbed before entering the lungs.

Monabiravir is an oral drug that is activated through metabolism in the body. When it enters the cell, it is converted into rnA-like building blocks. In the first stage, a viral replication machine called RNA polymerase integrates this building block into the SARS-COV-2 RNA genome. However, unlike Remdesivir, which slows viral RNA polymerase, monabilavir does not directly interfere with the function of this viral replication machine. Instead, in the second stage, the RNA-like building blocks are linked to the building blocks of the virus's genetic material. "When the viral RNA is then replicated to make a new virus, it contains many errors, called mutations," said Florian Kabinger, first author of the paper and a doctoral student in Cramer's lab. As a result, the pathogen can no longer proliferate."

The antiviral candidate, Molnupiravir (yellow), is integrated into viral RNA, where it causes mutations (purple) that ultimately prevent the virus from replicating, Pictures from MPI F. Biophysical Chemistry/ Florian Kabinger, Christian Dienemann and Patrick.

Monabilavir also appears to induce mutations in other RNA viruses, preventing them from spreading further. "This compound has the potential to be used to treat many viral diseases," Hobartner said. Monabilave has a lot of potential." This promising drug candidate is currently in phase 3 clinical studies, where it is being tested on a large number of patients. An announcement on whether monabiravir can be safely approved as a drug is likely in the second half of this year. The U.S. government is already optimistic, having recently obtained about 1.7 million doses of Monabiravir, worth more than $1 billion.

[Antiviral]

 

 

Eidd-2801 inhibits the replication of several RNA viruses, including SARS-COV-2 (the causative agent of COVID-19), and has been shown to improve lung function, reduce weight loss, and reduce the amount of virus in the lung in animal studies with two different coronaviruses (SARS-COV1 and MERS). In addition to its activity against coronavirus, EIDD-2801 has shown activity in laboratory studies against seasonal influenza, respiratory syncytial virus, Chikungunya virus, Ebola virus, Venezuelan equine encephalitis virus and eastern Equine encephalitis virus.

 

[In vivo activity]

 

Eidd-2801 (50-500 mg/kg; Oral; Every 12 hours 3 days) has a strong antiviral effect, can prevent SARS-COV replication and disease.

Pharmacological effects

 

 

Eidd-2801 is a compound similar to Remdesivir, and both drugs work by mimicking ribonucleotides, the main building blocks of RNA molecules. When the virus replication, which can be mixed with virus RNA molecules, replace some normal when copy of the original virus nucleic acid base sequence, cause the replication of the virus nucleic acid sequence errors, error accumulation, these fatal sequence is amiss mutation, will eventually stop viral replication, amplification and spread.

 

[Biological activity]

 

Molnupiravir (EIDD-2801, MK-4482) is an oral bioactive riboside analogue β -D-N4-hydroxycytidine (NHC; Eidd-1931), exhibiting broad spectrum of antiviral activity against the pathogens of SARS-COV-2, MERS-CoV, SARS-CoV and COVID-19.

 

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