Sarms Raw Powder GW-0742/GW0742 CAS NO.317318-84-6

Details:

Quick Detail:

Product Name:GW0742
Cas:317318-84-6
MF:C21H17F4NO3S2
MW:471.5
Purity: 99%
Appearance: white crystalline powder;
Application: Bodybuilding Muscle Growth.
DeliveryTime: within 3 days

Usage: Pharmaceutical material, Steroid hormone, Anabolin. As a male hormone and anabolic hormones.

Description:

1. GW0742 is a high affinity ppar-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice.

2. High throughput screening campaign was conducted to identify small molecules with the ability to inhibit

3. The interaction between the vitamin d receptor (vdr) and steroid receptor coactivator.

4. These inhibitors represent novel molecular probes to modulate gene regulation mediated by vdr. the peroxisome proliferator-activated receptor δ (pparδ) agonist gw0742 was among the identified vdr-coactivator inhibitors and has been characterized herein as a pan nuclear receptor antagonist at concentrations higher than 12.1 µm.

5. The highest antagonist activity for gw0742 was found for vdr and the androgen receptor (ar). surprisingly, gw0742 behaved as ppar agonist/antagonist activating transcription at lower concentration and inhibiting this effect at higher concentrations.

6. Unique spectroscopic property of gw0742 was identified as well. in the presence of rhodamine-derived molecules, gw0742+ increased fluorescence intensity and fluorescence polarization at an excitation wavelength of 595 nm and emission wavelength of 615 nm in a dose dependent manner.

7. The gw0742-inhibited nr-coactivator binding resulted in a reduced expression of five different nr target genes in lncap cells in the presence of agonist. especially vdr target genes cyp24a1, igfbp-3 and trpv6 were negatively regulated by gw0742.

8. GW0742 is the first vdr ligand inhibitor lacking the secosteroid structure of vdr ligand antagonists. nevertheless, the vdr-meditated downstream process of cell differentiation was antagonized by gw0742 in hl-60 cells that were pretreated with the endogenous vdr agonist 1,25-dihydroxyvitamin d3.

 Uses with gw-0742.

1.The first and most common use is that of increased endurance. gw0742 has been banned for professional athletes due to the unfair advantage it provides to endurance athletes. anyone want a drastic increase in endurance will find that gw truly shines in this aspect. it takes effect very quickly and the results can be staggering. a common dose of 10 mg day will provide a significant increase in endurance.

2.The second common usage with gw0742 is that of fat loss. many users turn to gw as it has shown to melt off fat while still being non-catabolic. you will find that you can still hold on to some muscle as you are losing fat. it helps when you are running it in conjunction with sarms ostarine and s4, to hold on to as much muscle as possible. a dosage of 10 mg a day will provide good amounts of fat loss, but an increase to 20 mg a day will provide much more in this area.

FAQ
Q1: Have your Product Quality been Approved by Third Party Lab

A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China. So you will be assured with Good Quality if you choose us. 
 
Q2: How do you treat quality complaint

A: First of all, our QC department will do strict examination of our export products by HPLC, UV, GC,TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: How to cooperate with us

You can contact us for cooperation through the website contact information, or contact with the salesmen in our company. We will connect you about the specific detail via email. 

Q4: Do you Accept Sample Order

A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q5: Is there any discount

A: Yes, for larger quantity, we always support with better price. 

Q6: Do you accept VISA business credit card

A: Sorry we don't accept VISA credit card,
We'd like to accept T/T , Moneygram ,,Paypal and Bitcoin.

Q7: How long does it take to the goods arrived

A:It is Depending on your location,
For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q8: Do you have any reshipment policy  

We have good after-sale service and re-shipment policy if the parcel  lose.
Our long association with  our clients has brought great benefits.
We always take the upmost care in the packaging of our products .
Our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship.

Company introduction：

Hubei Mawer Biotechnology Co., Ltd. is a comprehensive pharmaceutical company, which is mainly engaged in the research, development, production and sales of steroids, anti-tumor drugs, antiviral drugs and other raw materials and pharmaceutical intermediates, as well as the technology transfer and product customization services of related products. The company has import and export rights, 90% of the products are exported to Europe,America,Japan, South Korea, India, Bangladesh  and Southeast.

At the beginning of the company's establishment, the company has maintained close cooperation with R & D institutions and well-known pharmaceutical companies and enterprises at home and abroad. After the company was founded, it has a good cooperation team and resources, including the production facilities of the cooperation team, complete detection means and strong technical force. The cooperative factory is located in Ezhou Economic Development Zone, Hubei Province, covering an area of 20000 square meters and a building area of 11000 square meters. It has two GMP standard production workshops and a multi-functional pilot plant. The team has high-tech talents, including 15 doctors, 8 masters, 4 senior technical titles and 3 professors. The team can quickly open the drug synthesis route, optimize the product process route quickly and protect the commercialization of products.

The company has always adhered to the path of quality innovation and service seeking new sustainable development, and is committed to understanding the personalized needs of customers, providing high-quality API and pharmaceutical intermediates for all kinds of customers around the world, and striving to achieve win-win cooperation. "Quality first, customer first, speed first, quality and low price" are our tenets. We sincerely hope to cooperate sincerely with customers and friends at home and abroad to achieve win-win situation together.

Our company offers variety of products which can meet your multifarious demands. We adhere to the management principles of "quality first, customer first and credit-based" since the establishment of the company and always do our best to satisfy potential needs of our customers. Our company is sincerely willing to cooperate with enterprises from all over the world in order to realize a win-win situation since the trend of economic globalization has developed with anirresistible force.