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Sarcosine 107-97-1 intermediate Sarcosine chemical research Sarcosine
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Sarcosine CAS 107-97-1 In stock
2-(MethylaMino)acetic acid sodiuM
Product Name: | Sarcosine |
Synonyms: | Sarcosine in stock GMP Factory;2-(MethylaMino)acetic acid sodiuM;(methylamino)ethanoicacid;Acetic acid, (methylamino)-;CH3NHCH2COOH;Glycine, N-methyl-;Glycine,N-methyl-;Methylglycine |
CAS: | 107-97-1 |
MF: | C3H7NO2 |
MW: | 89.09 |
EINECS: | 203-538-6 |
Product Categories: | -;Aliphatics;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Amino ACIDS SERIES;Sarcosine [Sar];Amino Acids |
Mol File: | 107-97-1.mol |
Sarcosine Chemical Properties |
Melting point | 208-212 °C (dec.)(lit.) |
Boiling point | 165.17°C (rough estimate) |
density | 1.1948 (rough estimate) |
refractive index | 1.4368 (estimate) |
Fp | >100℃ |
storage temp. | Store at RT. |
solubility | H2O: 1 M at 20 °C |
pka | 2.21(at 25℃) |
form | Crystals or Powder |
color | Colorless or white to yellow |
PH | 6.1 (100g/l, H2O, 20℃) |
Water Solubility | 1480 g/L (20 ºC) |
Sensitive | Hygroscopic |
Merck | 14,8373 |
BRN | 1699442 |
CAS DataBase Reference | 107-97-1(CAS DataBase Reference) |
NIST Chemistry Reference | Sarcosine(107-97-1) |
EPA Substance Registry System | Glycine, N-methyl-(107-97-1) |
Safety Information |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 24/25-36-26 |
WGK Germany | 1 |
RTECS | VQ2897000 |
F | 3 |
TSCA | Yes |
HS Code | 29224995 |
MSDS Information |
Provider | Language |
---|---|
H-Sar-OH | English |
ACROS | English |
SigmaAldrich | English |
ALFA | English |
Sarcosine Usage And Synthesis |
Description | Sarcosine is the N-methyl derivative of glycine. It can be metabolized to the glycine through sarcosine dehydrogenase. It can be naturally found in many body tissues including muscles. In the laboratory, sarcosine could be synthesized through the reaction between chloroacetic acid and methylamine. Sarcosine is a potential interesting direction for the treatment of mental illness such as schizophrenia, possibly being related to its effect of increasing the glycine content in the brain, which increased the NMDA receptor activity. Sarcosine is also effective in the treatment of depression. Recent study has shown that sarcosine might be an important bio-marker for prostate cancer. |
References | # # |
Chemical Properties | White crystalline powder |
Uses | Has been found in starfish and sea urchins. It is used as intermediate in the synthesis of antienzyme agents for toothpaste. Found to be a marker for prostate cancer bioagression. |
Uses | Sarcosine can improve people's intelligence, especially for exams such as the students need to temporarily increase the effectiveness of intelligence is more obvious. sarcosine can increase muscle strength and anaerobic explosiveness.To prevent damage caused by the brain injury. Sarcosine can effectively improve athletic performance,power, and shorten muscle recovery time. |
Uses | sarcosine is a naturally occurring amino acid that is used in cosmetic formulations as a skin conditioner. There are some studies indicating that it is effective for oily skin. Its chemical name is n-methyl glycine. |
Definition | ChEBI: A N-alkylglycine that is the N-methyl derivative of glycine. It is an intermediate in the metabolic pathway of glycine. |
General Description | Deliquescent crystals or powder. Has a sweetish taste. |
Air & Water Reactions | Deliquescent. Water soluble. |
Reactivity Profile | Sarcosine is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). Sarcosine is incompatible with acids. . |
Fire Hazard | Flash point data for Sarcosine are not available. Sarcosine is probably combustible. |
Biological Activity | Endogenous inhibitor of GlyT1 that displays antipsychotic activity. Potentiates the action of glycine on the NMDA glycine binding site. |
Purification Methods | Crystallise sarcosine from absolute EtOH, 95% EtOH or H2O. It sublimes at 180-185o/0.3mm with 99.1% recovery [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Cocker & Harris J Chem Soc 1291 1940, Cocker & Lapworth J Chem Soc 1897 1931, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2750 1961, Beilstein 4 III 1121, 4 IV 2363.] |
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