CasNo.1228780-72-0,1-((2-(4-chlorophenyl)-4,4-dimethyl cyclohex-1-enyl)methyl)piperazine CAS 1228780-72-0,(1228780-72-0) Suppliers

1 Gram	FOB Price:USD 10.0000 -15.0000

Min.Order :1 Gram
Purity: 99%
Payment Terms : T/T,

Keywords

1-((2-(4-chlorophenyl)-4,4-dimethyl cyclohex-1-enyl)methyl)piperazine CAS 1228780-72-0 1228780-72-0

Quick Details

Appearance:white powder
Application:Animal Pharmaceuticals
PackAge:carton boc
ProductionCapacity:1000000|Kilogram|Month
Storage:cool and dry
Transportation:ship,fly

Superiority:

Hebei Mojin Biotechnology Co., Ltd,Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.

Adenosine triphosphate can be used in the disease caused by tissue injury and activity reduction of ecto enzyme , including heart failure, carditis, miocardial infarction, cerebral arteriosclersis, coronary sclerosis, progressive muscular atrophy , cerebral hemorrhage , chronic hepatitis, cirrhosis of liver and hearing handicap, etc.

Details:

Product Detailed

Abt-199 showed low sensitivity to Bcl-XL, McL-1 and Bcl-W with Ki of 48nM,>444nM and 245nM, respectively. Abt-199 effectively inhibited FL5.12-Bcl-2 cells,RS4; 11 cells, EC50 of 4nM and 8nM, respectively, showed low activity on FL5.12-Bcl-XL cells, EC50 of 261nM. Abt-199 chemicalbook induced RS4; 11 cells exhibited rapid apoptosis, cytochrome C release, caspase activation, phosphatidylserine externalization, and sub-G0/G1DNA accumulation. Quantitative western blotting showed that the sensitivity of ABT-199 to NHL, DLBCL, MCL, AML and ALL cell lines was strongly correlated with bcl-2 expression. Abt-199 also induced CLL apoptosis with an average EC50 of 3.0nM.Abt-199 (100mg/kg) treated RS4; The maximum tumor growth inhibition rate was 95% and the tumor growth was delayed by 152%. Chemicalbookabt-199, either alone or in combination with SDX-105 and other agents, also inhibited tumor growth in DoHH2 and Granta 519 grafts.

Product Name:	ABT-199
Chemical name:	Venetoclax Intermediate 1
CAS No.:	1228780-72-0
Molecular formula:	C19H27ClN2
Appearance:	White Powder
Storage:	Store in a dry and cool place.
Shelf life:	2 years
Package:	25kgs/drum, 1kg/Aluminum foil bags