Pivaldehyde

Details:

Pivaldehyde Chemical Properties
Melting point     6 °C(lit.)
Boiling point     74 °C730 mm Hg(lit.)
density     0.793 g/mL at 25 °C(lit.)
refractive index     n20/D 1.378(lit.)
Fp     4 °F
storage temp.     2-8°C
form     Liquid
color     Clear colorless
Specific Gravity    0.793
Water Solubility     Negligible
Sensitive     Air Sensitive
BRN     506060
InChIKey    FJJYHTVHBVXEEQ-UHFFFAOYSA-N
CAS DataBase Reference    630-19-3(CAS DataBase Reference)
NIST Chemistry Reference    Propanal, 2,2-dimethyl-(630-19-3)
EPA Substance Registry System    Propanal, 2,2-dimethyl- (630-19-3)
Safety Information
Hazard Codes     F,Xi,F+
Risk Statements     11-37/38-43
Safety Statements     16-23-33-24
RIDADR     UN 1989 3/PG 2
WGK Germany     3
F     8
TSCA     Yes
HazardClass     3
PackingGroup     III
HS Code     29121900
MSDS Information
Provider    Language
Trimethylacetaldehyde    English
ACROS    English
SigmaAldrich    English
ALFA    English
Pivaldehyde Usage And Synthesis
Description    Trimethylacetaldehyde (also known as Pivaldehyde) is the trimethyl form of acetaldehyde. It is an aldehyde with a sterically bulky R group, the tertiary-butyl group being attached to the carbonyl, >C=O. It is a useful reagent in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. It is useful in streoselective synthesis application as well as in aldol condensation reactions. As a derivative of acetaldehyde, trimethyl acetaldehyde can be used for the production of acetate. It can also be used as the precursor for manufacturing of pyridine derivatives, pentaerythritol, and crotonaldehyde.
Chemical Properties    Clear colorless liquid
Uses    Commonly used building block in aldol condensation reactions.
Uses    Trimethylacetaldehyde is used as a stereoselective synthesis application. It is also used as a building block used in aldol condensation reactions. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff.
References    Ho, Tse Lok, et al. Pivaldehyde. Fieser and Fieser's Reagents for Organic Synthesis. John Wiley & Sons, Inc. 2006.
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Pivaldehyde Preparation Products And Raw materials
Raw materials    3,3-Dimethyl-2-oxobutyric acid-->2-hydroxy-2-methylpropionaldehyde
Preparation Products    2,2-Dimethyl-1,3-propanediol-->Clomazone-->(S)-2-Methylproline-->METHYL ISOCYANOACETATE-->N-(Trimethylsilyl)-2,2-dimethylpropane-1-imine-->2,2-DIMETHYL-3-HEXANOL-->1,9-BIS-BOC-1,5,9-TRIAZANONANE-->methyl (2S)-2-amino-3,3-dimethylbutanoate-->2,2-DIMETHYL-3-HEXANONE-->(2S,5S)-(-)-2-TERT-BUTYL-3-METHYL-5-BENZYL-4-IMIDAZOLIDINONE-->Ethyl pivaloylacetate-->2-AMINO-5-TERT-BUTYL-1,3,4-THIADIAZOLE-->2R,5S)-5-benzyl-2-tert-butyl-3-MethyliMidazolidin-4-one