Ethambutol 74-55-5 98% purity
Product Name: Ethambutol
Synonyms: ETHAMBUTOL;(+)-2,2-(Ethylenediimino)di-1-butanol;(+)-2,2’-(ethylenediimino)di-1-butanol;(+)-n,n’-bis(1-(hydroxymethyl)propyl)ethylenediamine;(+)-s,s-ethambutol;(r)-2,2’-(1,2-ethanediyldiimino)bis-1-butanol;2,2’-(1,2-ethanediyldiimino)bis-,(r-(r*,r*))-1-butano;2’-(1,2-ethanediyldiimino)bis-(r)-1-butano
CAS: 74-55-5
MF: C10H24N2O2
MW: 204.31
EINECS: 200-810-6
Product Categories:
Mol File: 74-55-5.mol
Melting point 199-204℃
alpha D25 +13.7° (c = 2 in water)
Boiling point 345℃
density 1.0048 (rough estimate)
refractive index 1.4610 (estimate)
RTECS EL3640000
Fp >110°(230°F)
storage temp. Keep in dark place,Sealed in dry,2-8°C
pka pKa 6.6 (H2O) (Uncertain);9.5(H3O) (Uncertain)
Water Solubility Soluble in water. Also soluble in chloroform and methylene chloride
Safety Information
Hazardous Substances Data 74-55-5(Hazardous Substances Data)
Toxicity LD50 oral in rat: 998mg/kg
Originator Myambutol,Lederle,US,1967
Uses Antibacterial.
Uses Ethambutol is an antitubercular antibiotic.
Definition ChEBI: An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial d ug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant str ins of M. tuberculosis are readily produced if ethambutol is used alone.
Indications Ethambutol is a water-soluble, heat-stable compound that acts by inhibition of arabinosyl transferase enzymes that are involved in cell wall biosynthesis. Nearly all strains of M. tuberculosis and M. kansasii and most strains of Mycobacterium avium-intracellulare are sensitive to ethambutol. Drug resistance relates to point mutations in the gene (EmbB) that encodes the arabinosyl transferases that are involved in mycobacterial cell wall synthesis.
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