CasNo.161796-78-7,Esomeprazole Sodium CAS 161796-78-7,(161796-78-7) Suppliers

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Keywords

Esomeprazole Sodium CAS : 161796-78-7 161796-78-7

Quick Details

Appearance:white powder
Application:Animal Pharmaceuticals
PackAge:carton boc
ProductionCapacity:1000000|Kilogram|Month
Storage:cool and dry
Transportation:ship,fly

Superiority:

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Details:

Product Detailed

Name		Esomeprazole sodium
Synonyms		5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl-1H-benzimidazole sodium salt

Molecular Structure

Molecular Formula		C17H20N3NaO3S
Molecular Weight		369.41
CAS Registry Number		161796-78-7

Esomeprazole is in a group of drugs called proton pump inhibitors. Esomeprazole decreases the amount of acid produced in the stomach.

Esomeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Esomeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

Esomeprazole sodium is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.IC50 value:Target: proton pumpEsomeprazole sodium (Nexium) is the S-isomer of omeprazole and acts as a proton pump inhibitor and gastric antisecretory agent indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis. Esomeprazole 0.4 and 0.8 mg/mL as the sodium salt in the infusion solutions tested is chemically and physically stable for at least 2 days at room temperature and 5 days under refrigeration.

Function

Esomeprazole sodium is used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome.

Specification

Test items	Specifications	Result
Appearance	White or slightly coloured powder,slight hygroscopic	almost white powder
Identification A. IR B.Enantiomeric purity C.Reaction of maganesium D. Water	IR Conforms to the CRS.(2.2.24) Impurity F ≤0.2%(2.2.29) It gives reaction of magnesium(2.3.1) 6.2%~8.0%(2.5.12)	Complies 0.05% Complies 7.3%
Absorbance	The absorbance is not greater than 0.20 at 440nm.(2.2.25)	0.12
Related substances(HPLC) Impurity E Impurity D Unspecified impurities Total impurity Impurity F	(2.2.29) ≤0.15% ≤0.15% ≤0.10% ≤0.3% ≤0.2%(2.2.29)	0.04% 0.10% 0.03% 0.2% 0.05%
Magnesium	3.30%~3.55%	3.46%
Water by K.F.	6.2%~8.0%(2.5.12)	7.3%
Assay(HPLC)	98.0%~102.0%(2.2.29)	99.9%
Residual solvents: a) Acetne b)Etyl aetate c)Methylene chloide d)Methnol e)Toluee f)Benzene	Not more than 5000ppm Not more than 5000ppm Not more than 100ppm Not more than 3000ppm Not more than 890ppm Not more than 2ppm	3ppm Not detected Not detected 77ppm Not detected Not detected