linagliptin API

linagliptin API

linagliptin API

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1 Gram

Negotiable

  • Min.Order :1 Gram
  • Purity: 99
  • Payment Terms : L/C,D/P,T/T

Keywords

linagliptin; Trajenta; BI-1356-BS; 8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione; Ondero; BI-1356; Linagliptin; Tradjenta linagliptin(API)

Quick Details

  • Appearance:white power
  • Application:ANTIDIABETIC
  • PackAge:DRUMS/CARTON
  • ProductionCapacity:10|Metric Ton|Week
  • Storage:in sealed air resistant place
  • Transportation:sea or air or express delivery

Superiority:

Anqing World Chemical Co.,Ltd.Mainly responsible for the development of domestic and international business.In 2015,Haikang established the second branch,called Anqing Xuanyu Medical&Technology Co., Ltd, it is an R&D company that selects reliable technology and cooperative research partner for our corporation.

Haikang is committed to R&D,manufacture and sales of chemical raw materials API and intermediates.Meanwhile,we also provide services like product customization,process improvement,achievement transfer, etc. Through years effort,Haikang has made remarkable achievements in the R&D and production of anti-virus,antidiabetic,antineoplastic,beauty and whitening resist oxidation series API and intermediates.The main products are Ganciclovir, Sitagliptin, Vildagliptin, Silodosin and Imatinib API and Intermediates.

To deal with increasingly competition,Haikang adheres to “Customer is First,Technology is Leading,Quality is Life,Honesty for Developing”,and optimizes actively the products and better service to customers.

Details:

In vitro, Linagliptin shows an effective inhibitory effect on DPP-4, and has a low affinity for hERG channels and M1 receptors (IC50295nM). In vitro, Linagliptin acts as a competitive inhibitor, Ki is 1nM, and is selective for DPP-4 compared to DPP-8, DPP-9, aminopeptidase N and P, prolyl oligopeptidase, trypsin, Plasmin, and thrombin are 10,000 times higher than that of fibroblast activation protein 90 times higher. In vivo studies In male Wistar rats, beagle dogs, and rhesus monkeys, Linagliptin showed high-efficiency, long-lasting, and effective inhibitory activity against DPP-4. It was administered orally at a dose of 1 mg/kg, which can reach all species. More than 70% inhibition of Chemicalbook. 45 minutes before the oral glucose tolerance test, Linagliptin was orally administered to db/db mice, and it dose-dependently reduced blood glucose fluctuations from 0.1 mg/kg (15% inhibition) to 1 mg/kg (66% inhibition). By inhibiting the activity of DPP-4, Linagliptin reduces the expression of pro-inflammatory markers Oxygenase-2 and Macrophage Inflammatory Protein-2, and enhances the formation of myofibroblasts when ob/ob mice heal wounds. Uses Linagliptin Linagliptin, developed by Boehringer Ingelheim, was approved by the FDA on May 2, 2011. It is used to combine diet and exercise to improve the control of blood glucose levels in people with type 2 diabetes. Linagliptin improves blood glucose control in patients by inhibiting dipeptidyl peptidase-4 (DPP-4). Linagliptin upstream and downstream product information

linagliptin;8-[(3R)-3-Amino-1-piperidinyl]-7-(2-butynyl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione;(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione;1H-Purine-2,6-dione, 8-((3R)-3-amino-1-piperidinyl)-7-(2-butynyl)-3,7-dihydro-3-methyl-1-((4-methyl-2-quinazolinyl)methyl)-;Bi 1356;Ondero;8-[(3R)-3-AMino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-Methyl-1-[(4-Methyl-2-quinazolinyl)Methyl]-1H-purine-2,6-dione;8-[(3R)-3-AMino-1-piperidinyl]-7-(2-butynyl)-3,7-dihydro-3-Methyl-1-[(4-Methyl-2-quinazolinyl)Methyl]-1H-purine-2,6-d

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