Effect of heparin lithium on whole blood cell analysis

Details:

Heparin  is an anticoagulant, mainly in the form of heparin sodium salt or heparin lithium salt. Its main function is to inhibit blood coagulation in blood collection vessels. Whole blood cytometry is a widely used instrument in the field of medical detection. Theoretically, potassium EDTA is an ideal reagent for anticoagulation in whole blood analysis, but heparin lithium anticoagulant is still needed in some specific needs. Although it has been said in some comments that "heparin anticoagulant" cannot be used for whole blood cell analysis, it must be corrected. Here, "heparin" refers to "heparin sodium" rather than heparin lithium.

The reason why heparin anticoagulant can not be used in whole blood cell analysis is that excessive heparin will cause WBC aggregation, and heparin salt powder will cause leukocyte aggregation, which will affect the results of blood cell analysis. However, the study found that about 3.25% of heparin sodium did not significantly aggregate WBC and did not prevent PLT aggregation. 3.25% of heparin lithium could prevent WBC and PLT aggregation within 1 hour and PLT aggregation was slow within 2 hours. Conclusion heparin lithium anticoagulant can be used for whole blood cell analysis within one hour of blood extraction. In the experimental operation, the results of heparin lithium in whole blood cell analysis are the same as those measured by EDTA dipotassium.

Through the experiment, we also learned that 3.25% heparin lithium anticoagulant tube can also be used to check the samples of blood routine, liver function, kidney function and electrolyte. In this way, using one anticoagulant blood sample can check several items, which can not only save the cost, but also reduce the pollution of waste test samples to the environment.

Desheng biochemical is a manufacturer specializing in the production of blood collection additives. It independently develops and produces heparin lithium, heparin sodium and other products. The potency is ≥ 150IU and the quality is reliable. If necessary, please go to the official website to inquire about the product details or contact the customer service for consultation. We look forward to your letter!