Leflunomide API High Quality 99% CAS No 75706-12-6 Leflunomide Powder

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100 Gram	Negotiable

100 Gram

Negotiable

Min.Order :100 Gram
Purity: 99%
Payment Terms : T/T

Keywords

Leflunomide Leflunomide Powder 75706-12-6

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Despcription

Leflunomide is a derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation.

Function

For the management of the signs and symptoms of active rheumatoid arthritis (RA) to improve physical function and to slow the progression of structural damage associated with the disease. Has also been used for the prevention of acute and chronic rejection in recipients of solid organ trasnplants and is designated by the FDA as an orphan drug for this use.

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