99% up by HPLC 5-Isothiocyanato-3-(Trifluoromethyl)Picolinonitrile 951753-87-0

99% up by HPLC 5-Isothiocyanato-3-(Trifluoromethyl)Picolinonitrile 951753-87-0

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price:USD 50.0000 -800.0000

1 Kilogram

FOB Price:USD 50.0000 -800.0000

Min.Order :1 Kilogram
Purity: 99% up
Payment Terms : L/C,D/A,D/P,T/T

Keywords

5-Isothiocyanato-3-(Trifluoromethyl)Picolinonitrile apalutamide intermediate apalutamide

Quick Details

Appearance:White powder
Application:Pharmaceutical Intermediates
PackAge:1kg/bag ;5kg/drum:25KG/drum
ProductionCapacity:20|Kilogram|Day
Storage:in low tempreture
Transportation:Room temperature

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Details:

Product name	5-isothiocyanato-3-(trifluoromethyl)picolinonitrile / Apalutamide intermediate
CAS No.	951753-87-0
Molecular Formula	C8H2F3N3S
Molecular Weight	229.18
Quality Standard	98% up by HPLC
Appearance	White powder

Molecular Structure:

Synonyms:	5-isothiocyanato-3-(trifluoromethyl)picolinonitrile
Density:	1.41±0.1 g/cm3(Predicted)
Boiling Point:	367.7±42.0 °C(Predicted)
PSA:	81.13000
LogP:	2.70638

5-isothiocyanato-3-(trifluoromethyl)picolinonitrile is one of key intermediates of apalutamide (N-2).

Function of Apalutamide

As a second-generation nonsteroidal androgen receptor inhibitory drug, apalutamide can prevent the fusion of androgen and receptors, and block the transfer of AR to the nucleus of cancer cells. In addition, apalutamide can also control androgen and promote the growth of cancer cells.

The safety and efficacy of apalutamide are based on a randomized clinical trial of 1,207 patients with non-metastatic, castration-resistant prostate cancer. Patients in the trial received apalutamide or placebo. All patients also received hormone therapy, either with a gonadotropin-releasing hormone (GnRH) analog, or with surgery to lower the amount of testosterone in the body (surgical castration). Median metastasis-free survival was 40.5 months for patients taking apalutamide, compared with 16.2 months for patients taking placebo. From the above experiments, we can see that the effect of apalutamide in the treatment of prostate cancer is very significant.