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Pregabalin 148553-50-8 Manufacturer of Pregabalin 148553-50-8 Pregabalin Capsule High Quality Pregabalin High purity Pregabalin 148553-50-8 Pregabalin Capsule High Quality Pregabalin
Preparation method of (S)-3-aminomethyl-5-methylhexanoic acid
discloses a preparation method of pregabalin, comprising the following steps: (1) dropwisely adding bromine into a sodium hydroxide aqueous solution to generate a reaction solution I; dissolving (R)-(-)-3-carbamylmethyl-5-methylhexanoic acid with a sodium hydroxide aqueous solution to obtain a reaction solution II; (2) dropwise adding the reaction solution II into the reaction solution I to carry out a Hofmann degradation reaction to obtain a reaction solution III; (3) filtering the reaction solution III to obtain a filtrate I; (4) adding concentrated hydrochloric acid into the filtrate I, and stirring and filtering to obtain a solid wet product; and (5) adding the solid wet product into a solvent I, heating, stirring, dissolving, filtering, cooling the filtrate, stirring, filtering, and drying a filter cake to obtain the pregabalin. The preparation method is simple in technological process, good in impurity control effect and suitable for industrial production.
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√1、The product quality has passed the professional production process and quality inspection, and the purity is more than 99%;
√ 2. The products shall be packed in special standard barrels or according to the requirements of customers. All packages should be carefully transported and protected according to customer requirements;
√3、The product from the raw material procurement, production planning, feeding capacity, production process, FG testing, warehousing inspection and other aspects of the whole process of quality control, strict supervision, through the authenticity, accuracy, timeliness and integrity of data records, to ensure the continuous improvement of product quality, and to put an end to all non-standard phenomen;
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