Details:

Product Introduction

Name: tianeptinesulfate

English synonym :tianeptinesulfate; (Thiazepin-11-ylAmino)HeptanoicAcidSemisulfateMonohydrateTianeptineSemisulfateMonohydrate; 7 - [(3 - Chloro - 6, 10 - dihydro - - methyl - 5, 5 - dioxidodibenzo [c, f] [1, 2] thiazepin - 11 - yl) amino] heptanoicacidsulfatehydrate (2:1:2); Tianeptinehemisulfatemonohydrate(THM); 7 - [(3-6 - methyl - Chloro - 5, 5 - dioxido - 6, 11 - dihydrodibenzo [c, f] [1, 2] thiazepin - 11 - yl) amino] heptanoicacidsulfatehydrate (2:1:2); Tianeptinehemisulfatehydrate; Thiazepin-11-ylAmino)HeptanoicAcidSemisulfate; THM

CAS no. : 1224690-84-9

Molecular formula: C42H56Cl2N4O14S3

Molecular weight: 1008.01344

Product Function

Its elimination half-life is 2.5 to 3 hours. The elimination half-life has been found to be increased to 4 to 9 hours in the elderly. The drug has an active metabolite, with a much longer elimination half-life. Tianeptine is excreted 65% in the urine and 15% in feces. depression research has formulated several key goals for the development of novel therapeutics, including faster onset of antidepressant effects, efficacy in treatment-resistant subjects and minimization of side effects.1 The atypical antidepressant tianeptine (Figure 1a), an agent with established clinical efficacy, already addresses several limitations of standard antidepressants.2 Namely, it shows fast effects against some depressive symptoms (cognitive and anxiety symptoms), is effective in patients resistant to selective serotonin reuptake inhibitor therapy3 and shows a better side effect profile compared with selective serotonin reuptake inhibitors and tricyclic antidepressants.2 Interestingly, unlike other tricyclic antidepressants, tianeptine does not inhibit biogenic amine transporters, and despite longstanding interest in this agent, its direct target, and thus its molecular mechanism of action, have remained elusiv.