Sitagliptin Powder 99% CAS 486460-32-6

Details:

English name Sitagliptin
CAS No. 486460-32-6
Molecular weight 407.314
Density 1.6±0.1 g/cm3
Boiling point 529.9±60.0 °C at 760 mmHg
Molecular formula C16H15F6N5O
Flash point 274.3±32.9 °C

Clinical application
for type 2 diabetes.

Pharmacodynamics
This drug is a dipeptidyl peptidase-4 (DPP-4) inhibitor that controls blood sugar levels by protecting and enhancing the effects of endogenous incretin. Glucose-dependent insulin-releasing peptide (GIP) and glucagon-like peptide-1 (GLP-1), are incretins released in response to dietary intake.

GLP-1 and GIP can increase insulin synthesis and release from islet β cells through intracellular signaling pathways, and GLP-1 can also reduce the secretion of glucagon from islet α cells, resulting in decreased hepatic glucose production. However, both GLP-1 and GIP are rapidly metabolized by DPP-4, resulting in a loss of their insulinotropic effects.

The drug inhibits the degradation of incretin by DPP-4, so it can enhance the function of GLP-1 and GIP, increase insulin release and reduce circulating glucagon levels (this effect is glucose-dependent). This drug selectively inhibits DPP-4, but has no inhibitory activity on DPP-8 or DPP-9.

Applicable symptoms
Erectile dysfunction and pulmonary hypertension.

Dosage
The recommended dose of this product is 10mg, which is taken before sexual activity and is not affected by food. If the effect of taking 10mg is not significant, you can take 20mg, at least 30 minutes before sex.
The maximum frequency of dosing is once a day.

Quality:

1. order products, before delivery, according to customer needs, we will provide such as coa, msds, nuclear magnetic resonance (nmr), chiral product spinning, or customer specified demand quality indicators.
2. can be given sample and technical confirmation.
3. professional packaging, or packaging and transportation according to the needs of customers.

Service:
1. track the product freight service all the way.
2. to cooperate with the customs clearance.
3. optimize the production process according to the customer's needs.
4. joint research and development of products according to customer needs.