Metformin Powder 99% CAS 657-24-9

Details:

English name Metformin
CAS No. 657-24-9
Molecular weight 129.164
Density 1.3±0.1 g/cm3
Boiling point 172.5±23.0 °C at 760 mmHg
Molecular formula C4H11N5
Flash point 58.1±22.6 °C

Pharmacokinetics
It is an oral hypoglycemic agent for biguanide, and its effect is weaker than that of phenformin. The absorption rate after oral administration is only 50%. The tmax is approximately 2 hours and is not bound to plasma proteins in plasma. Almost all excreted by urine, the first phase t1/2 is about 3 hours, the second phase t1/2 is about 12 to 14 hours, and the hypoglycemic effect can last for 8 hours.

Indications
(1) Metformin tablets are the first choice for the treatment of ineffective type 2 diabetes mellitus with simple diet control and physical exercise, especially obese type 2 diabetes mellitus.

(2) Combining this product with insulin can reduce the dosage of insulin and prevent the occurrence of hypoglycemia.

(3) It can be used in combination with sulfonylurea hypoglycemic drugs, which has a synergistic effect.

Precautions
(1) Use with caution in patients with a history of lactic acidosis and elderly patients. Lactic acidosis may occur due to the accumulation of this product. Once it occurs, it will lead to life-threatening. Therefore, renal function should be monitored and the lowest effective dose should be given to reduce the risk of lactic acidosis. Risk occurs.

(2) Fever, coma, infection and other stress states, surgery and the use of iodine-containing contrast agents for examinations, should temporarily stop taking this product, as it may lead to deterioration of acute renal function.

(3) When this product is combined with sulfonylurea drugs and insulin, it can cause hypoglycemia. Drinking alcohol should be avoided as much as possible while taking this product. Easily lead to hypoglycemia or lactic acidosis. Use with caution in patients with liver dysfunction.

(4) This product can interfere with the absorption of vitamin B12, so it is recommended to monitor the blood

Applicable symptoms
Erectile dysfunction and pulmonary hypertension.

Dosage
The recommended dose of this product is 10mg, which is taken before sexual activity and is not affected by food. If the effect of taking 10mg is not significant, you can take 20mg, at least 30 minutes before sex.
The maximum frequency of dosing is once a day.

Quality:

1. order products, before delivery, according to customer needs, we will provide such as coa, msds, nuclear magnetic resonance (nmr), chiral product spinning, or customer specified demand quality indicators.
2. can be given sample and technical confirmation.
3. professional packaging, or packaging and transportation according to the needs of customers.

Service:
1. track the product freight service all the way.
2. to cooperate with the customs clearance.
3. optimize the production process according to the customer's needs.
4. joint research and development of products according to customer needs.