99% up by HPLCCaspo...

99% up by HPLCCaspofungin Intermediate Pneumocandin B0 135575-42-7
99% up by HPLCCaspofungin Intermediate Pneumocandin B0 135575-42-7
99% up by HPLCCaspofungin Intermediate Pneumocandin B0 135575-42-7
99% up by HPLCCaspofungin Intermediate Pneumocandin B0 135575-42-7
99% up by HPLCCaspofungin Intermediate Pneumocandin B0 135575-42-7

99% up by HPLCCaspofungin Intermediate Pneumocandin B0 135575-42-7

Min.Order / FOB Price:Get Latest Price

1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: 99.9%
  • Payment Terms : L/C,D/A,D/P,T/T

Keywords

Caspofungin Intermediate Pneumocandin B0 Pneumocandin

Quick Details

  • Appearance:White or almost white hygroscopic powder
  • Application:API
  • PackAge:25kg per drum
  • ProductionCapacity:1000|Kilogram|Month
  • Storage:Normal temperature
  • Transportation:normal temperature.

Superiority:

Why is SINOWAY:

1) Specialized in pharmaceutical and healthcare industrial for 34 years.

2) ISO 9001:2015 & SGS audited supplier . 

3) Accept various payment terms : T.T 30-60 days.

4) We have warehouse in USA with quickly shipment .

5) We can do different terms of FOB ,CIF/CIP ,DDP ...

 

Details:

Product name

Caspofungin intermediate /

Pneumocandin B0

CAS No.

135575-42-7

Molecular Formula

C50H80N8O17

Molecular Weight

1065.23

Quality Standard

97% up by HPLC

Appearance

White to off-white powder

 

ITEMS

SPECIFICATION

RESULT

Appearance

Yellowish or white powder

Conforms

Water

 9.0%

4.53%

 

Identity

FT- IR

Correspond to the standard

 

Conforms

HPLC retention time

Correspond to the standard

 

Conforms

 

 

 

Chromatographic Purity

Pneumocandin A0 (PNA)  0.10%

IP-1  1.5%

IP-2  1.5%

IP-3  1.5%

Pneumocandin C0 (PNC)  0.30%

Any individual unspecified impurities  0.50%

Total impurities (including PNC)  6.0%

0.07%

0.36%

Not detected

0.08%

0.07%

0.25% max

1.21%

Assay

(on anhydrous basis)

 94.0%

97.6%

 

Related solvents

Methanol  3000ppm

Ethanol  5000ppm

2-propanol  5000ppm

Dichloromethane  600ppm

Not detected

Not detected

393ppm

Not detected

Conclusion

The product complies with the in-house specification

 

What is Pneumocandin B0

Pneumocandin B0 is a new class of cyclolipopeptide natural antifungal drugs produced by fermentation of filamentous fungi. It has a cyclic hexapeptide core and a fatty acid side chain structure. and Pneumocystis carinii are effective, so more and more people's attention. The cyclic hexapeptide core after removing the fatty acid side chain of Numeroctin B0 is the main raw material for the synthesis of Caspofungin.

 

Function of Caspofungin

 

Caspofungin is the first marketed echinocandin in the world. Its mechanism of action is unique. It targets the fungal cell wall and specifically inhibits the synthesis of β(1,3)-d-glucan in the cell wall and destroys the fungal cell wall. The integrity of the fungal cells makes the intracellular osmotic pressure unstable, which eventually leads to the lysis of the fungal cells. Mammalian cells do not contain -β-(1,3)-glucan, and there is no similar cell wall synthesis process. Therefore, while caspofungin is antifungal, it will not damage and affect human cells. In vitro pharmacological studies have shown that caspofungin is effective against a variety of Candida, endemic fungi, Aspergillus and Pneumocystis carinii, so it has attracted more and more attention. Pneumocandin B0 is a new class of cyclolipopeptide natural antifungal drugs produced by fermentation of filamentous fungi. It has a cyclic hexapeptide core and a fatty acid side chain structure. and Pneumocystis carinii are effective, and more and more people's attention.

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