CasNo.135575-42-7,99% up by HPLCCaspofungin Intermediate Pneumocandin B0 135575-42-7,(135575-42-7) Suppliers

1 Kilogram	Negotiable

Min.Order :1 Kilogram
Purity: 99.9%
Payment Terms : L/C,D/A,D/P,T/T

Keywords

Caspofungin Intermediate Pneumocandin B0 Pneumocandin

Quick Details

Appearance:White or almost white hygroscopic powder
Application:API
PackAge:25kg per drum
ProductionCapacity:1000|Kilogram|Month
Storage:Normal temperature
Transportation:normal temperature.

Superiority:

Why is SINOWAY:

1) Specialized in pharmaceutical and healthcare industrial for 34 years.

2) ISO 9001:2015 & SGS audited supplier .

3) Accept various payment terms : T.T 30-60 days.

4) We have warehouse in USA with quickly shipment .

5) We can do different terms of FOB ,CIF/CIP ,DDP ...

Details:

Product name	Caspofungin intermediate / Pneumocandin B0
CAS No.	135575-42-7
Molecular Formula	C₅₀H₈₀N₈O₁₇
Molecular Weight	1065.23
Quality Standard	97% up by HPLC
Appearance	White to off-white powder

ITEMS	SPECIFICATION	RESULT
Appearance	Yellowish or white powder	Conforms
Water	≤ 9.0%	4.53%
Identity	FT- IR Correspond to the standard	Conforms
Identity	HPLC retention time Correspond to the standard	Conforms
Chromatographic Purity	Pneumocandin A0 (PNA) ≤ 0.10% IP-1 ≤ 1.5% IP-2 ≤ 1.5% IP-3 ≤ 1.5% Pneumocandin C0 (PNC) ≤ 0.30% Any individual unspecified impurities ≤ 0.50% Total impurities (including PNC) ≤ 6.0%	0.07% 0.36% Not detected 0.08% 0.07% 0.25% max 1.21%
Assay (on anhydrous basis)	≥ 94.0%	97.6%
Related solvents	Methanol ≤ 3000ppm Ethanol ≤ 5000ppm 2-propanol ≤ 5000ppm Dichloromethane ≤ 600ppm	Not detected Not detected 393ppm Not detected
Conclusion	The product complies with the in-house specification

What is Pneumocandin B0

Pneumocandin B0 is a new class of cyclolipopeptide natural antifungal drugs produced by fermentation of filamentous fungi. It has a cyclic hexapeptide core and a fatty acid side chain structure. and Pneumocystis carinii are effective, so more and more people's attention. The cyclic hexapeptide core after removing the fatty acid side chain of Numeroctin B0 is the main raw material for the synthesis of Caspofungin.

Function of Caspofungin

Caspofungin is the first marketed echinocandin in the world. Its mechanism of action is unique. It targets the fungal cell wall and specifically inhibits the synthesis of β(1,3)-d-glucan in the cell wall and destroys the fungal cell wall. The integrity of the fungal cells makes the intracellular osmotic pressure unstable, which eventually leads to the lysis of the fungal cells. Mammalian cells do not contain -β-(1,3)-glucan, and there is no similar cell wall synthesis process. Therefore, while caspofungin is antifungal, it will not damage and affect human cells. In vitro pharmacological studies have shown that caspofungin is effective against a variety of Candida, endemic fungi, Aspergillus and Pneumocystis carinii, so it has attracted more and more attention. Pneumocandin B0 is a new class of cyclolipopeptide natural antifungal drugs produced by fermentation of filamentous fungi. It has a cyclic hexapeptide core and a fatty acid side chain structure. and Pneumocystis carinii are effective, and more and more people's attention.