Betamethasone Base

Superiority:

Product Name:    Betamethasone
Synonyms:    17,21-trihydr;betamethasone standard;(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;Betamethasone Base & Salts;Betamethasone,9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16β-methylprednisolone;Betamethasone (200 mg);BetaMethasone (Celestone);BetaMethasone SolutioM
CAS:    378-44-9
MF:    C22H29FO5
MW:    392.47
EINECS:    206-825-4
Product Categories:    CELESTONE;Pharmaceutical intermediate;Biochemistry;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;Hydroxyketosteroids;Steroids;API
Mol File:    378-44-9.mol
Betamethasone Structure
Betamethasone Chemical Properties
Melting point     235-237°C
alpha     D +108° (acetone)
Boiling point     568.2±50.0 °C(Predicted)
density     1.1283 (estimate)
refractive index     118 ° (C=1, Dioxane)
storage temp.     0-6°C
solubility     Practically insoluble in water, sparingly soluble in anhydrous ethanol, very slightly soluble in methylene chloride.
form     neat
pka    12.13±0.70(Predicted)
Water Solubility     58mg/L(25 ºC)
Merck     14,1180
CAS DataBase Reference    378-44-9(CAS DataBase Reference)
NIST Chemistry Reference    Pregna-1,4-diene-3,20-dione, 9alpha-fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-(378-44-9)
EPA Substance Registry System    Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11.beta.,16.beta.)- (378-44-9)
Safety Information
Hazard Codes     Xi,Xn,T
Risk Statements     40-48/20/21-61
Safety Statements     22-36-45-53
WGK Germany     2
RTECS     TU4000000
HS Code     29379000
Hazardous Substances Data    378-44-9(Hazardous Substances Data)
Toxicity    LD50 oral in mouse: > 4500mg/kg