CasNo.3644-61-9,Tolperisone hydrochlorideCAS NO.3644-61-9,(3644-61-9) Suppliers

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Keywords

Tolperisone hydrochloride 1-piperidino-2-methyl-3-(p-tolyl)-3-propanonehydrochloride 2,4'-dimethyl-3-piperidinopropiophenone monohydrochloride

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Appearance:colourless viscous liquid
Application:Synthetic fragrances
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ProductionCapacity:10000|Metric Ton|Month
Storage:Room temperature
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Details:

Product Name:	Tolperisone hydrochloride
Synonyms:	1-piperidino-2-methyl-3-(p-tolyl)-3-propanonehydrochloride;LABOTEST-BB LT00772344;2-Methyl-1-(4-methylphenyl)-3-(1-piperidyl)propan-1-one hydrochloride;Tolperizone hydrochloride;4'-METHYL-2-(1-PIPERIDINYLMETHYL)-PROPIOPHENONE HCL;4'-methyl-2-(1-piperidinylmethyl)-propiophenone hydrochloride;2,4'-DIMETHYL-3-PIPERIDINOPROPIOPHENONE HYDROCHLORIDE;2,4'-dimethyl-3-piperidinopropiophenone monohydrochloride
CAS:	3644-61-9
MF:	C16H24ClNO
MW:	281.82
EINECS:	222-876-5
Product Categories:	Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	3644-61-9.mol

Tolperisone hydrochloride Chemical Properties

Melting point	181-183°C
storage temp.	room temp
solubility	H2O: >20mg/mL
form	solid
color	white
PH	pH(50g/l, 25℃) : 4.5～5.5
Water Solubility	almost transparency
Merck	14,9522
CAS DataBase Reference	3644-61-9(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	20/21/22-52/53-36/37/38
Safety Statements	26-36-45-61-36/37-37/39
WGK Germany	3
RTECS	UH1575500
Toxicity	LD50 s.c. in mice: 620 mg/kg (Porszasz, 1961)

MSDS Information

Tolperisone hydrochloride Usage And Synthesis

Chemical Properties	White Solid
Originator	Tolperisone hydrochloride,Shanghai Abochem Chemical Co.
Uses	Tolperisone hydrochloride can be used as a muscle relaxant.
Manufacturing Process	To 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added an excess of thionyl chloride and the reaction mixture refluxed until completed. It was then taken to dryness under reduced pressure and the residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate. An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone was purified by distilling the base (boiling point 106-107°C/1 mm) and reconverting to the hydrochloride, melting point 216-217°C.
Therapeutic Function	Muscle relaxant, Vasodilator
Biochem/physiol Actions	Tolperisone is derived from piperidine and possesses membrane stabilizing action. It helps in reducing the effect of spasticities associated with the nervous and muscular system. It exhibits muscle relaxant action through attenuating voltage-gated sodium channels in the brain stem.