CasNo.375815-87-5,Varenicline tartrate CAS NO.375815-87-5,(375815-87-5) Suppliers

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Purity: 99%
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Keywords

Varenicline tartrate 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine (2R,3R)-2,3- dihydroxybutanedioate 6,10-Methano-6H-pyrazino(2,3-H)(3)benzazepine, 7,8,9,10-tetrahydro-, (2R,3R)-2,3-dihydroxybutanedioate (1:1)

Quick Details

Appearance:colourless viscous liquid
Application:Synthetic fragrances
PackAge:drum
ProductionCapacity:10000|Metric Ton|Month
Storage:Room temperature
Transportation:By Sea/Air/DHL

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Details:

Varenicline tartrate Basic information

Product Name:	Varenicline tartrate
Synonyms:	VARENICLINE TARTRATE;Varenicline tartrate for research;7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine (2R,3R)-2,3- dihydroxybutanedioate;Champix;CP 526555-18;Varenicline Tartarate;CS-291;,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-
CAS:	375815-87-5
MF:	C17H19N3O6
MW:	361.34926
EINECS:	638-780-5
Product Categories:	Heterocycles;Intermediates & Fine Chemicals;Heterocyclic Compounds;APIs;Chantix, Champix;Inhibitors;Pharmaceuticals;Pfizer compounds
Mol File:	375815-87-5.mol

Varenicline tartrate Chemical Properties

Melting point	206-208°C
storage temp.	room temp
solubility	DMSO: >5mg/mL
form	powder
color	white to beige
InChIKey	TWYFGYXQSYOKLK-UHFFFAOYSA-N

Safety Information

Hazard Codes	Xn,N,T,F
Risk Statements	22-50-39/23/24/25-23/24/25-11
Safety Statements	22-57-45-36/37-16-7
RIDADR	UN 3077 9 / PGIII
WGK Germany	3

MSDS Information

Varenicline tartrate Usage And Synthesis

Chemical Properties	Tan Solid
Uses	Nicotinic a4 acetylcholine receptor partial agonist. Aid in smoking cessation.
Uses	Nicotinic α4β2 acetylcholine receptor partial agonist. Aid in smoking cessation.
Uses	Varenicline tartrate is a prescription medication used to treat smoking addiction. Varenicline is a nicotinic receptor partial agonist. In this respect, it is similar to cytisine and different from the nicotinic antagonist, bupropion, and nicotine replacement ther
Definition	ChEBI: A tartrate salt obtained by reaction of varenicline with one equivalent of (R,R)-tartaric acid. A partial agonist for nicotinic cholinergic receptors, it is used as an aid to giving up smoking.
Brand name	Chantix (Pfizer).
Biological Activity	Orally active, subtype-selective partial agonist at α 4 β 2 nicotinic receptors (K i values are 0.06, 240, 322 and 3540 nM for α 4 β 2, α 3 β 4, α 7, α 1 β γ δ receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo .
Biochem/physiol Actions	Varenicline tartrate is a partial α4β2 nicotinic receptor agonist and α7 full agonist. Varenicline competitively binds to α4β2 receptors and partially stimulates without creating a full nicotine effect, while simultaneoudly blocking the ability of nicotine to bind to the receptors. Varenicline thus blocks the ability of nicotine to activate α4β2 receptors and stimulate the central nervous mesolimbic dopamine system, believed to be the neuronal mechanism underlying reinforcement and reward experienced upon smoking.