Sale Gw0742 SARM 31...

Sale Gw0742 SARM 317318-84-6 Steroids White Powder
Sale Gw0742 SARM 317318-84-6 Steroids White Powder

Sale Gw0742 SARM 317318-84-6 Steroids White Powder

Min.Order / FOB Price:Get Latest Price

10 Gram

Negotiable

  • Min.Order :10 Gram
  • Purity: 99%
  • Payment Terms : T/T,

Keywords

Gw0742 317318-84-6 99% HPLC 317318-84-6 Sale 317318-84-6

Quick Details

  • Appearance:white powder
  • Application:body building
  • PackAge:foil bag
  • ProductionCapacity:1|Metric Ton|Day
  • Storage:
  • Transportation:international express

Superiority:

1. Name: GW-0742
2. Other Name: GW610742
3. CAS: 317318-84-6
4. Molecular Formula:C21H17F4NO3S2
5. Formula Weight:471.5
6. appearance:white solid
7.  Mp:134.5-135.5 °C

Gw0742 Description:

1. GW0742 is a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice.

 

2. A high throughput screening campaign was conducted to identify small molecules with the ability to inhibit

 

3. the interaction between the vitamin D receptor (VDR) and steroid receptor coactivator.

 

4. These inhibitors represent novel molecular probes to modulate gene regulation mediated by VDR. The peroxisome proliferator-activated receptor δ (PPARδ) agonist GW0742 was among the identified

VDR-coactivator inhibitors and has been characterized herein as a pan nuclear receptor antagonist at concentrations higher than 12.1 µM.

 

5. The highest antagonist activity for GW0742 was found for VDR and the androgen receptor (AR). Surprisingly, GW0742 behaved as PPAR agonist/antagonist activating transcription at lower concentration

and inhibiting this effect at higher concentrations.

 

6. A unique spectroscopic property of GW0742 was identified as well. In the presence of rhodamine-derived molecules, GW0742+ increased fluorescence intensity and fluorescence polarization at an excitation

wavelength of 595 nm and emission wavelength of 615 nm in a dose dependent manner.

 

7. The GW0742-inhibited NR-coactivator binding resulted in a reduced expression of five different NR target genes in LNCaP cells in the presence of agonist. Especially VDR target genes CYP24A1,

IGFBP-3 and TRPV6 were negatively regulated by GW0742.

 

8. GW0742 is the first VDR ligand inhibitor lacking the secosteroid structure of VDR ligand antagonists. Nevertheless, the VDR-meditated downstream process of cell differentiation was antagonized

by GW0742 in HL-60 cells that were pretreated with the endogenous VDR agonist 1,25-dihydroxyvitamin D3.
 

Details:

Company description:


Wuhan Godbullraw Chemical Co.,ltd, founded in 2011, is a modern advanced enterprise specializing in custom synthesis and R&D and exportation of APIs, peptides, 
Sarms, Local anesthetics, plant extract etc, we build coopration with labs and factory qualitied with GMP, DMF, FDA in china and worldwild. 
We take advantage on integrating factory resources and lab customized projects.for customer demand, we continue to expand the industry chain in familiar areas, 
and at the same time we also keep develop new product supply chain.

We have 7 synthesis labs and 3 scale-up  labs and 3 analysis lab toatly spaced with 13500 square meters, basement of these experienced chemist with high educated, 
we have strong supply system and purity raw. As the shipping , we cooperate with 10 experienced shipping companies to make sure ETA by a safe delivery to worldwild


Our service: 
Quality:  Our products match CP and USP standard before comes out from factory and rechecked by third institution like Jonashik and scores well always, 
we supply test report credit 30$ for next order

Shipping: available to worldwide, ETA 12 days around,customer just only need to supply us ship info and then wait the order delivery after payment, 
we will supply tracking number immediately when pack sent out
we experienced on shipping, we can promise free reshipping if seized by custom unfortunately

Payment: T/T,,Bitcoin

 

Our advantage:

Rich experience.

We have specialized in this field for 11 years. Our steroids and hormones have been exported to overseas, like Europe, Africa, Asia, America and other countries.
 And we have got very good feedback from our customers, and established long friendly relations of cooperation.

High quality products with the best price

1.All powders are factory directly supplying and have much in stock.

2.Before each powder send out, it all will be tested again by our technician, if the quality good, then it can be sent out to customers.

Professtional packing and fast delivery

1.Professtional team for packing, different country and quantity order have different packing way, sure package the products the best to your order.

2.We have mass stock, so that we can guarantee all the package can be sent out as soon as possible after you pay and should arrive your hands 3-7 days safely 
by DHL,TNT,FEDEX,HKEMS,UPS,etc.

Best pre-sell and after-sell service.

1.Once the package send out, tracking number and packing picture should email you later

2.For raw powder buyer, we also can help you cook steroid powder into injection and supply you all the things to make ready use injection, such as 10ml vials,
0.22um-0.45um whatman filter,crimper machine and filter pump


 

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