Top Quality 99% up ...

Top Quality 99% up 8-Bromo-7-But-2-Ynyl-3-Methyl-Purine-2,6-Dione / Linagliptin Intermediate 666816-98-4
Top Quality 99% up 8-Bromo-7-But-2-Ynyl-3-Methyl-Purine-2,6-Dione / Linagliptin Intermediate 666816-98-4
Top Quality 99% up 8-Bromo-7-But-2-Ynyl-3-Methyl-Purine-2,6-Dione / Linagliptin Intermediate 666816-98-4
Top Quality 99% up 8-Bromo-7-But-2-Ynyl-3-Methyl-Purine-2,6-Dione / Linagliptin Intermediate 666816-98-4
Top Quality 99% up 8-Bromo-7-But-2-Ynyl-3-Methyl-Purine-2,6-Dione / Linagliptin Intermediate 666816-98-4

Top Quality 99% up 8-Bromo-7-But-2-Ynyl-3-Methyl-Purine-2,6-Dione / Linagliptin Intermediate 666816-98-4

Min.Order / FOB Price:Get Latest Price

2 Kilogram

FOB Price:USD 55.0000 -200.0000

  • Min.Order :2 Kilogram
  • Purity: 99% up
  • Payment Terms : L/C,D/A,D/P,T/T,

Keywords

8-Bromo-7-But-2-Ynyl-3-Methyl-Purine-2,6-Dione Linagliptin Intermediate 666816-98-4 Linagliptin Intermediate

Quick Details

  • Appearance:White powder
  • Application:Intermediates, Flavor & Fragrance Intermediates, Synt
  • PackAge:1kg/bag ;5kg/drum:25KG/drum
  • ProductionCapacity:20|Metric Ton|Month
  • Storage:in low tempreture
  • Transportation:in low tempreture

Superiority:

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Details:

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Product Information

 

Product name

8-Bromo-7-but-2-ynyl-3-methyl-purine-2,6-dione;

Linagliptin intermediate

CAS No.

666816-98-4

Molecular Formula

C10H9BrN4O2

Molecular Weight

297.111

Quality Standard

99% up by HPLC

Appearance

White powder

 

COA of 8-Bromo-7-but-2-ynyl-3-methyl-purine-2,6-dione

 

ITEMS

SPECIFICATION

RESULT

Appearance

White powder

Conforms

Water content by KF

 0.50%

0.12%

 

 

Identity

IR:

Conforms to spectrum of the standard

 

Conforms

HPLC

Conforms to retention time of the standard

 

Conforms

 

 

Solvent residue by GC

Ethyl acetate  500ppm

67 ppm

Heptane  500ppm

55 ppm

Methanol  300ppm

23 ppm

Toluene  89ppm

ND

Acetonitrile  41ppm

ND

Residue on ignition

 0.10%

0.02%

Assay(By Anhydrous base)

99.0103.0%

99.89%

 

Usage

 

8-Bromo-7-but-2-ynyl-3-methyl-purine-2,6-dione is one of key intermediates of Linagliptin.

 

Physical properties of 8-Bromo-7-but-2-ynyl-3-methyl-purine-2,6-dione:

(1)ACD/LogP: 1.615;

(2)# of Rule of 5 Violations: 0;

(3)ACD/LogD (pH 5.5): 1.62;

(4)ACD/LogD (pH 7.4): 1.60;

(5)ACD/BCF (pH 5.5): 9.94;

(6)ACD/BCF (pH 7.4): 9.65;

(7)ACD/KOC (pH 5.5): 180.10;

(8)ACD/KOC (pH 7.4): 174.78;

(9)#H bond acceptors: 6 ;

(10)#H bond donors: 1;

(11)#Freely Rotating Bonds: 1;

(12)Polar Surface Area: 67.23 Å2;

(13)Index of Refraction: 1.694;

(14)Molar Refractivity: 66.441 cm3;

(15)Molar Volume: 173.014 cm3;

(16)Polarizability: 26.339×10-24 cm3;

(17)Surface Tension: 58.492 dyne/cm;

(18)Density: 1.717 g/cm3

 

We have a professional team specialized in custom developing & manufacturing pharmaceutical intermediates or APIs.

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