CasNo.50-23-7,factory supply GMP,DMF,CEP Levocarnitine,(50-23-7) Suppliers

1 Kilogram	Negotiable

Min.Order :1 Kilogram
Purity: USP/EP/BP
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Keywords

Levocarnitine Carnitine 50-23-7

Quick Details

Appearance:White crystallization
Application:Reaction properties,Immunosuppressive effect,anti- Virus response
PackAge:1kg/tin
ProductionCapacity:1|Metric Ton|Day
Storage:
Transportation:AIR SEA TRAIN

Superiority:

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Product Name:	L-carnitine
CAS:	541-15-1
MF:	C7H15NO3
MW:	161.2
EINECS:	208-768-0
Product Categories:	Inhibitors;fine chemicals, specialty chemicals, intermediates, electronic chemical, organic synthesis, food additives, pharmaceuticals;FINE Chemical & INTERMEDIATES;Miscellaneous;chiral;pharmaceutical chemicals;Amino Acids;Ammonium Polyhalides, etc. (Quaternary);Quaternary Ammonium Compounds;L-Carnitine Series;Vitamins and derivatives;Food Additives;Aliphatics;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File:	541-15-1.mol

Details:

L-carnitine Usage And Synthesis

Indications and Usage

Carnitine is a type of vitamin B, and its structure is similar to that of amino acids. It is mainly used to help transport long-chain fatty acids to provide energy and to prevent fat from collecting in the heart, liver, and skeletal muscles. Carnitine can prevent disordered fat metabolism due to diabetes, fatty liver disease and heart disease, and it can reduce heart damage, lower blood triglyceride, aid in weight loss, and increase the antioxidant effects of vitamin E and C. Meats and giblets are high in carnitine. Artificially synthesized carnitine includes L-carnitine, D-carnitine, and DL-carnitine, and only L-carnitine has physiological activities. On the other hand, D-carnitine and DL-carnitine competitively inhibit the activity of carnitine acetyltransferase (CAT) and carnitine palmitoyltransferase (PTC) to prevent cells’ fat metabolism, thus harming human nutrition. L-carnitine was first discovered in 1905 by Russian chemists Gulewitsch and Krimberg in infusion broth, and its chemical structure was determined in 1927 by Tomita and Senju. L-carnitine is a white crystalline or transparent powder, and its melting point is 200℃ (decompose). It is easily soluble in water, lye, methanol and ethanol, barely soluble in acetone and acetate, and insoluble in chloroform. It is hygroscopic. L-carnitine can be used as an animal nutrition enhancer, and it is mainly used to enhance protein-based food additives to promote fat absorption and utilization. L-carnitine also is a nutrition enhancer that is mainly used in soy-based infant foods, sports nutritional foods and weight loss foods to promote fat absorption and utilization. According to China’s regulations, the permitted amount in biscuits, drinks, and dairy beverages is 600-3000mg/kg; in solid beverages, liquids, and gel capsules, 250-600mg/kg; in formula, 300-400mg/kg; in infant foods, 70-90mg/kg (1g tartrate is equivalent to 0.68g l-carnitine). L-carnitine can also be used as an appetite booster. L-carnitine affects the elimination and utilization of ketone bodies, so it can be used as a biological antioxidant to eliminate free radicals, maintain membrane stability, increase animal immunity and resistance to disease and stress. Oral L-carnitine can increase the speed of sperm maturation and sperm vitality, it can increase the number of forward-moving sperm and motile sperm in oligospermia and asthenospermia patients, thus increasing the women’s clinical pregnancy rate, and it does so safely and effectively. L-carnitine can bind with organic acids and the large amounts of acyl coenzyme derivatives produced in children with fatty acid metabolism disorder and turn them into water soluble acylcarnitine to be excreted through urine. This not only aids in controlling acute acidosis occurrences, but also effectively improves long-term prognosis.

Mechanisms of Action

L-carnitine cannot participate in protein biosynthesis, but it promotes ketone body utilization and nitrogen generation to an extent. Its main function is to promote fatty acid beta oxidation, which occurs in the liver and the mitochondria of other tissue cells. It is known that free fatty acids and acyl coenzyme A cannot penetrate the inner mitochondrial membrane, but acylcarnitine can do so swiftly. Thus, it is determined that L-carnitine is the carrier that transports fatty acid and acyl forms into the mitochondrial membrane. The mechanisms of this transporting process are still unknown, but it is certain that carnitine acyl-CoA transferase is the key enzyme in this process. It has two isoenzymes, one of which is carnitine acyl-CoA transferase I, positioned on the outer side of the membrane. When fatty acid is catalyzed by acyl-CoA-synthatase to produce acyl-CoA, it is transported by carnitine acyl-CoA transferase I into the membrane. After it has entered the membrane, it is catalyzed by the second isoenzyme - carnitine acyl-CoA transferase II – to turned into a form of acyl-CoA that can be directly utilized by fatty acid catabolic enzymes. Afterwards, it releases energy through processes such as dehydrogenation and deoxygenation.
L-carnitine can also adjust the acyl ratio in mitochondria, thus affecting energy metabolism. L-carnitine can participate in the transportation of branched chain amino acid metabolites, which encourages the regular metabolism of branched chain amino acid.