Youngshe supply Custom peptide PNC-27 powder for lab research

Details:

PNC-27 is a membrane-active peptide that binds to the HDM-2 protein expressed in the cancer cell membranes of solid tissue tumor cells and induces transmembrane pore formation in cancer, but not in normal cells, resulting in tumor cell necrosis that is independent of p53 activity in these cells. 

PNC-27 is a peptide that contains p53 protein amino acid residues 12-26 of its HDM-2 binding domain attached to a transmembrane-penetrating sequence, also called the membrane residency peptide (MRP). Both PNC-27 and PNC-28 (which has a sequence that is identical to that of PNC-27 but lacks the first six amino acid residues of PNC-27 (i.e., p53 residues 17-26) are lethal to a wide variety of cancer cells with IC50 values ranging from around 75 ug/ml (18.6 uM) to 200 ug/ml (50 uM). On the other hand, neither peptide affects normal or untransformed cells in culture, including human hematopoietic stem cells even at the highest doses (around 500 ug/ml) tested. The latter finding suggests that both peptides would not be toxic to bone marrow function in contrast to the effects of many chemotherapeutic agents.

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Company Profile

Chengdu YoungShe Chemical Co Ltd is dedicating to be the most professional, efficient,and reliable partner for global customers on cosmetic peptides. You can select more than 200 kinds of cosmetic peptides here.And we are keeping developing new products and continuously marketing them for sale. YoungShe Chem provide a one-stop service on cosmetic peptides.It will save you lots of time,energy and money.You will have very pleasant experience with us.Youngshe Chem,your personal cosmetic peptide consult. Since Dec,2015, YoungShe group has expanded their business to botanical cosmetic active ingredient and related.

Our Advantages

1. Professionalism of production: With more than 20 years of experience in peptide production, to ensure the stability and reliability of each batch of peptide quality.
2. Professionalism of product efficacy: We are familiar with more than 300 kinds of cosmetic peptides that are now available worldwide, thorough research.
3. Professionalism of service: customer satisfaction is our greatest work.
4. Reliability: We always believe that only good reputation and product quality can make a good company.
5. Flexibility: We offer a variety of peptides, liquid, freeze-dried powder etc.
6. Variety products: We offer more than 200 peptides, including dipeptide, tripeptide, tetrapeptide, pentapeptide, hexapeptide, copper peptide, oligopeptide and so on.

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