CasNo.31690-09-2,China Biggest Factory & Manufacturer supply Levomefolic Acid 50MT/Year,(31690-09-2) Suppliers

50 Kilogram	FOB Price:USD 1.0000 -2.0000

Min.Order :50 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Levomefolic Acid 31690-09-2 Levomefolic Acid

Quick Details

Appearance:white powder
Application:chemicals industry
PackAge:25KG/Drum
ProductionCapacity:5|Metric Ton|Month
Storage:2-8°C
Transportation:By air /Sea/ coruier

Superiority:

Levomefolic Acid Basic information

Description Mechanism Medical application Storage

Product Name:	Levomefolic Acid
Synonyms:	(6S)-5-Methyltetrahydrofolic acid;5lLCH3-folateH4;L(-)-5-Methyl-5,6,7,8-tetrahydrofolic acid;lL-5-Methyltetrahydrofolic acid;N-[4-[[[(6S)-2-Amino-5-methyl-1,4,5,6,7,8-hexahydro-4-oxopteridine-6-yl]methyl]amino]benzoyl]-L-glutamic acid;N-[4-[[[[(6S)-2-Amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxopteridin]-6-yl]methyl]amino]benzoyl]-L-glutamic acid;(S)-N-[4-[[(2-Amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid;Levomefolic acid
CAS:	31690-09-2
MF:	C20H25N7O6
MW:	459.46
EINECS:
Product Categories:	Amines;Aromatics;Drug Analogues;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	31690-09-2.mol

Levomefolic Acid Chemical Properties

Melting point	215-218oC
density	1.62
storage temp.	Sealed in dry,Room Temperature
solubility	Aqueous Base (Slightly, Heated, Sonicated), DMSO (Slightly)
pka	3.51±0.10(Predicted)

Safety Information

MSDS Information

Levomefolic Acid Usage And Synthesis

Description	Levomefolic Acid is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid. It has been proposed for treatment of cardiovascular disease.
Mechanism	It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by methylenetetrahydrofolate reductase (MTHFR) from 5,10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by methionine synthase (MS).
Medical application	Levomefolic acid (5-MTHF) is the natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. IC50 value: Target: Folate analogLevomefolic acid has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. Levomefolic acid (5-MTHF) has the prominent antioxidant activity. A high dose of 5-MTHF or folic acid does not influence Natural killer (NK) cell function in vitro. Preliminary research suggests that levomefolic acid (L-methylfolate) taken with a first-line antidepressant may provide an adjunctive antidepressant effect for individuals who do not respond or have only a partial therapeutic response to SSRI or SNRI medication,and might be a more cost-effective adjunctive agent than second-generation antipsychotics.
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Uses	As a natural, active form of folic acid, Levomefolic Acid can be used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supple
Uses	A natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid. It has been proposed for treatment of cardiovascular disease.

Levomefolic Acid Preparation Products And Raw materials

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