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R-(+)-Alpha-Lipoic Acid R-ALA 1200-22-2
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(R)-(+)-1,2-Dithiolane-3-pentanoic acid Basic information |
Product Name: | (R)-(+)-1,2-Dithiolane-3-pentanoic acid |
Synonyms: | 5-[(3R)-1,2-dithiolan-3-yl]pentanoic acid;5-[(3R)-dithiolan-3-yl]pentanoic acid;5-[(3R)-dithiolan-3-yl]valeric acid;(R)-(+)-1,2-Dithiola;(R)-5-(1,2-Dithiolan-3-yl)pentanoic acid;(R)-Thioctic Acid (R)-1,2-Dithiolane-3-valeric Acid;D-lipoic acid;(R)-(+)-1,2-Dithiolane-3-pentanoic acid 97% |
CAS: | 1200-22-2 |
MF: | C8H14O2S2 |
MW: | 206.33 |
EINECS: | 638-752-2 |
Product Categories: | API;Sulfur & Selenium Compounds;Chiral Reagents;Chiral Building Blocks;Heterocyclic Building Blocks;Others;FINE Chemical & INTERMEDIATES;Heterocycles |
Mol File: | 1200-22-2.mol |
(R)-(+)-1,2-Dithiolane-3-pentanoic acid Chemical Properties |
Melting point | 48-52 °C(lit.) |
alpha | D23 +104° (c = 0.88 in benzene) |
Boiling point | 185-195 °C(Press: 0.5 Torr) |
density | 1.218±0.06 g/cm3(Predicted) |
refractive index | 114 ° (C=1, EtOH) |
Fp | >230 °F |
storage temp. | -20°C |
solubility | Acetonitrile (Slightly), Chloroform (Slightly), DMSO |
pka | 5.4(at 25℃) |
optical activity | [α]20/D +104°, c = 1 in chloroform |
Merck | 14,9326 |
CAS DataBase Reference | 1200-22-2(CAS DataBase Reference) |
Safety Information |
Risk Statements | 22-36/38 |
Safety Statements | 20-36-26-35 |
WGK Germany | 3 |
HS Code | 29349990 |
MSDS Information |
Provider | Language |
---|---|
SigmaAldrich | English |
(R)-(+)-1,2-Dithiolane-3-pentanoic acid Usage And Synthesis |
Chemical Properties | Yellow Crystalline Solid |
Uses | A fat-metabolism stimulator |
Uses |
α-Lipoic acid has been used as a reference standard for the analysis of α-lipoic acid in human plasma by high performance liquid chromatography coupled to electron capture detector (HPLC-ECD), in various food matrices and dietary supplements by HPLC combined with coulometric electrode array detector (CEAD) as well as electrospray ionization mass spectrometer (ESI-MS). |
General Description |
α-Lipoic acid is an antioxidant which is generally present in plants, animals and many other microorganisms. |
Biochem/physiol Actions | (R)-(+)-α-Lipoic acid was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes. It is a biological antioxidant with prooxidant activities, its therapeutic potential is widely investigated, e.g. in the treatment for Alzheimer′s disease. |
(R)-(+)-1,2-Dithiolane-3-pentanoic acid Preparation Products And Raw materials |
Preparation Products | DIHYDROLIPOIC ACID |
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