CasNo.1200-22-2,China Biggest Factory & Manufacturer supply R-(+)-Alpha-Lipoic Acid (R-ALA) 500MT/Year,(1200-22-2) Suppliers

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R-(+)-Alpha-Lipoic Acid R-ALA 1200-22-2

(R)-(+)-1,2-Dithiolane-3-pentanoic acid Basic information

Product Name:	(R)-(+)-1,2-Dithiolane-3-pentanoic acid
Synonyms:	5-[(3R)-1,2-dithiolan-3-yl]pentanoic acid;5-[(3R)-dithiolan-3-yl]pentanoic acid;5-[(3R)-dithiolan-3-yl]valeric acid;(R)-(+)-1,2-Dithiola;(R)-5-(1,2-Dithiolan-3-yl)pentanoic acid;(R)-Thioctic Acid (R)-1,2-Dithiolane-3-valeric Acid;D-lipoic acid;(R)-(+)-1,2-Dithiolane-3-pentanoic acid 97%
CAS:	1200-22-2
MF:	C8H14O2S2
MW:	206.33
EINECS:	638-752-2
Product Categories:	API;Sulfur & Selenium Compounds;Chiral Reagents;Chiral Building Blocks;Heterocyclic Building Blocks;Others;FINE Chemical & INTERMEDIATES;Heterocycles
Mol File:	1200-22-2.mol

(R)-(+)-1,2-Dithiolane-3-pentanoic acid Chemical Properties

Melting point	48-52 °C(lit.)
alpha	D23 +104° (c = 0.88 in benzene)
Boiling point	185-195 °C(Press: 0.5 Torr)
density	1.218±0.06 g/cm3(Predicted)
refractive index	114 ° (C=1, EtOH)
Fp	>230 °F
storage temp.	-20°C
solubility	Acetonitrile (Slightly), Chloroform (Slightly), DMSO
pka	5.4(at 25℃)
optical activity	[α]20/D +104°, c = 1 in chloroform
Merck	14,9326
CAS DataBase Reference	1200-22-2(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

(R)-(+)-1,2-Dithiolane-3-pentanoic acid Usage And Synthesis

Chemical Properties	Yellow Crystalline Solid
Uses	A fat-metabolism stimulator
Uses	α-Lipoic acid has been used as a reference standard for the analysis of α-lipoic acid in human plasma by high performance liquid chromatography coupled to electron capture detector (HPLC-ECD), in various food matrices and dietary supplements by HPLC combined with coulometric electrode array detector (CEAD) as well as electrospray ionization mass spectrometer (ESI-MS). It may be used as a reference standard for the determination of α-lipoic acid in human urine by isocratic reversed-phase HPLC and in α-lipoic acid capsules by HPLC with chemiluminescence detection.
General Description	α-Lipoic acid is an antioxidant which is generally present in plants, animals and many other microorganisms.
Biochem/physiol Actions	(R)-(+)-α-Lipoic acid was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes. It is a biological antioxidant with prooxidant activities, its therapeutic potential is widely investigated, e.g. in the treatment for Alzheimer′s disease.

(R)-(+)-1,2-Dithiolane-3-pentanoic acid Preparation Products And Raw materials

Preparation Products

(R)-(+)-1,2-Dithiolane-3-pentanoic acid Basic information

Product Name:	(R)-(+)-1,2-Dithiolane-3-pentanoic acid
Synonyms:	5-[(3R)-1,2-dithiolan-3-yl]pentanoic acid;5-[(3R)-dithiolan-3-yl]pentanoic acid;5-[(3R)-dithiolan-3-yl]valeric acid;(R)-(+)-1,2-Dithiola;(R)-5-(1,2-Dithiolan-3-yl)pentanoic acid;(R)-Thioctic Acid (R)-1,2-Dithiolane-3-valeric Acid;D-lipoic acid;(R)-(+)-1,2-Dithiolane-3-pentanoic acid 97%
CAS:	1200-22-2
MF:	C8H14O2S2
MW:	206.33
EINECS:	638-752-2
Product Categories:	API;Sulfur & Selenium Compounds;Chiral Reagents;Chiral Building Blocks;Heterocyclic Building Blocks;Others;FINE Chemical & INTERMEDIATES;Heterocycles
Mol File:	1200-22-2.mol

(R)-(+)-1,2-Dithiolane-3-pentanoic acid Chemical Properties

Melting point	48-52 °C(lit.)
alpha	D23 +104° (c = 0.88 in benzene)
Boiling point	185-195 °C(Press: 0.5 Torr)
density	1.218±0.06 g/cm3(Predicted)
refractive index	114 ° (C=1, EtOH)
Fp	>230 °F
storage temp.	-20°C
solubility	Acetonitrile (Slightly), Chloroform (Slightly), DMSO
pka	5.4(at 25℃)
optical activity	[α]20/D +104°, c = 1 in chloroform
Merck	14,9326
CAS DataBase Reference	1200-22-2(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

(R)-(+)-1,2-Dithiolane-3-pentanoic acid Usage And Synthesis

Chemical Properties	Yellow Crystalline Solid
Uses	A fat-metabolism stimulator
Uses	α-Lipoic acid has been used as a reference standard for the analysis of α-lipoic acid in human plasma by high performance liquid chromatography coupled to electron capture detector (HPLC-ECD), in various food matrices and dietary supplements by HPLC combined with coulometric electrode array detector (CEAD) as well as electrospray ionization mass spectrometer (ESI-MS). It may be used as a reference standard for the determination of α-lipoic acid in human urine by isocratic reversed-phase HPLC and in α-lipoic acid capsules by HPLC with chemiluminescence detection.
General Description	α-Lipoic acid is an antioxidant which is generally present in plants, animals and many other microorganisms.
Biochem/physiol Actions	(R)-(+)-α-Lipoic acid was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes. It is a biological antioxidant with prooxidant activities, its therapeutic potential is widely investigated, e.g. in the treatment for Alzheimer′s disease.