CasNo.22457-89-2,China Biggest Factory & Manufacturer supply Benfotiamine 200MT/Year,(22457-89-2) Suppliers

50 Kilogram	FOB Price:USD 1.0000 -2.0000

Min.Order :50 Kilogram
Purity: 99%
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Keywords

Benfotiamine Benfotiamine 22457-89-2

Quick Details

Appearance:white powder
Application:chemicals industry
PackAge:25KG/Drum
ProductionCapacity:20|Metric Ton|Month
Storage:2-8°C
Transportation:By air /Sea/ coruier

Superiority:

Benfotiamine Basic information

Product Name:	Benfotiamine
Synonyms:	benzoylthiamineo-monophosphate;berdi;betivina;benphothiamine;BENFOTAMINE (S-BENZOYLTHIAMINE-O-MONOPHOSPHATE);S-[2]-[(4-Amino-2-methyl-5-pyrimidinyl)methy-[formylamino]-1-[2-phosphonoxy)ethyl]-1-propenyloic ester phenylcarbathionoic acid;Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl];Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester
CAS:	22457-89-2
MF:	C19H23N4O6PS
MW:	466.45
EINECS:	245-013-4
Product Categories:	API;BIOTAMIN;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceutical intermediate;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Sulfur & Selenium Compounds
Mol File:	22457-89-2.mol

Benfotiamine Chemical Properties

Melting point	165 C
Boiling point	745.1±70.0 °C(Predicted)
density	1.444±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Aqueous Acid (Slightly), DMSO (Heated, Sonicated)
pka	1.84±0.10(Predicted)
Merck	14,1041
InChIKey	BTNNPSLJPBRMLZ-GHRIWEEISA-N
CAS DataBase Reference	22457-89-2(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	26-36
WGK Germany	2
RTECS	DH6910000

MSDS Information

Provider	Language
SigmaAldrich	English

Benfotiamine Usage And Synthesis

Chemical Properties	crystals
Originator	Biotamin,Sankyo
Uses	S-Benzoylthiamine O-monophosphate has been used to determine its effect on ischemia and reperfusion in skeletal muscles of rat.
Uses	Vitamin B1 analog. Synthetic S-acyl derivative of Thiamine (T344185).
Definition	ChEBI: A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.
Manufacturing Process	28.6 g 84% phosphoric acid was heated to temperature about 270°C. After cooling to 100°C 4 g thiamine hydrochloride (vitamin B1 hydrochloride) was added and left at temperature 100°C before an isolation of HCl was ended. After adding of an ice water and acetone, phosphate ester of vitamin B1 was fallen. The precipitate was dissolved in 17 ml 1 N HCl and stood at ambient temperature 7 days for a hydrolysis. Then a solution was with acetone diluted and the mixture was cooled, whereupon vitamin B1 monophosphate hydrochloride was isolated. The solution of 4.3 parts vitamin B1 monophosphate hydrochloride in 16 parts of water was diluted with 11 parts 15% NaOH, 2.1 parts benzoyl chloride was dropwise added with stirring and cooling. The obtained mixture was neutralized, evaporated in vacuum, acidified with concentrated HCl to pH 3.5- 4, whereupon a crude S-derivative of vitamin B1 monophosphate ester was precipitated. The product was suspended in water, was bringing with NaOH to pH 7 and was acidified to pH 4. 3.4 g refined S-benzoylthiamine Omonophosphate was prepared; MP: 165°C (with decomposition).
Therapeutic Function	Analgesic
General Description	S-Benzoylthiamine O-monophosphate (Benfotiamine) is an amphiphilic S-acyl thiamine derivative. It is a lipid-soluble vitamin. Benfotiamine contains a thiazole ring. Benfotiamine has a greater bioavailability than thiamine.
Biochem/physiol Actions	S-Benzoylthiamine O-monophosphate (Benfotiamine) is a therapeutic agent. It helps in the prevention of diabetic complications such as, retinopathy, neuropathy and nephropathy. Benfotiamine inhibits the synthesis of glycation end products (AGEs) in diabetes. Benfotiamine is considered as a nutraceutical product for the prevention of diabetic neuropathy.

Benfotiamine Preparation Products And Raw materials

Raw materials

Benzoyl chloride-->Thiamine hydrochloride-->Phosphoric acid

Details:

Benfotiamine Basic information

Product Name:	Benfotiamine
Synonyms:	benzoylthiamineo-monophosphate;berdi;betivina;benphothiamine;BENFOTAMINE (S-BENZOYLTHIAMINE-O-MONOPHOSPHATE);S-[2]-[(4-Amino-2-methyl-5-pyrimidinyl)methy-[formylamino]-1-[2-phosphonoxy)ethyl]-1-propenyloic ester phenylcarbathionoic acid;Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl];Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester
CAS:	22457-89-2
MF:	C19H23N4O6PS
MW:	466.45
EINECS:	245-013-4
Product Categories:	API;BIOTAMIN;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceutical intermediate;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Sulfur & Selenium Compounds
Mol File:	22457-89-2.mol

Benfotiamine Chemical Properties

Melting point	165 C
Boiling point	745.1±70.0 °C(Predicted)
density	1.444±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Aqueous Acid (Slightly), DMSO (Heated, Sonicated)
pka	1.84±0.10(Predicted)
Merck	14,1041
InChIKey	BTNNPSLJPBRMLZ-GHRIWEEISA-N
CAS DataBase Reference	22457-89-2(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	26-36
WGK Germany	2
RTECS	DH6910000

MSDS Information

Provider	Language
SigmaAldrich	English

Benfotiamine Usage And Synthesis

Chemical Properties	crystals
Originator	Biotamin,Sankyo
Uses	S-Benzoylthiamine O-monophosphate has been used to determine its effect on ischemia and reperfusion in skeletal muscles of rat.
Uses	Vitamin B1 analog. Synthetic S-acyl derivative of Thiamine (T344185).
Definition	ChEBI: A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.
Manufacturing Process	28.6 g 84% phosphoric acid was heated to temperature about 270°C. After cooling to 100°C 4 g thiamine hydrochloride (vitamin B1 hydrochloride) was added and left at temperature 100°C before an isolation of HCl was ended. After adding of an ice water and acetone, phosphate ester of vitamin B1 was fallen. The precipitate was dissolved in 17 ml 1 N HCl and stood at ambient temperature 7 days for a hydrolysis. Then a solution was with acetone diluted and the mixture was cooled, whereupon vitamin B1 monophosphate hydrochloride was isolated. The solution of 4.3 parts vitamin B1 monophosphate hydrochloride in 16 parts of water was diluted with 11 parts 15% NaOH, 2.1 parts benzoyl chloride was dropwise added with stirring and cooling. The obtained mixture was neutralized, evaporated in vacuum, acidified with concentrated HCl to pH 3.5- 4, whereupon a crude S-derivative of vitamin B1 monophosphate ester was precipitated. The product was suspended in water, was bringing with NaOH to pH 7 and was acidified to pH 4. 3.4 g refined S-benzoylthiamine Omonophosphate was prepared; MP: 165°C (with decomposition).
Therapeutic Function	Analgesic
General Description	S-Benzoylthiamine O-monophosphate (Benfotiamine) is an amphiphilic S-acyl thiamine derivative. It is a lipid-soluble vitamin. Benfotiamine contains a thiazole ring. Benfotiamine has a greater bioavailability than thiamine.
Biochem/physiol Actions	S-Benzoylthiamine O-monophosphate (Benfotiamine) is a therapeutic agent. It helps in the prevention of diabetic complications such as, retinopathy, neuropathy and nephropathy. Benfotiamine inhibits the synthesis of glycation end products (AGEs) in diabetes. Benfotiamine is considered as a nutraceutical product for the prevention of diabetic neuropathy.