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China Biggest Factory & Manufacturer supply High quality D-Mannose
China Biggest Factory & Manufacturer supply High quality D-Mannose
China Biggest Factory & Manufacturer supply High quality D-Mannose
China Biggest Factory & Manufacturer supply High quality D-Mannose
China Biggest Factory & Manufacturer supply High quality D-Mannose

China Biggest Factory & Manufacturer supply High quality D-Mannose

Min.Order / FOB Price:Get Latest Price

100 Kilogram

FOB Price:USD 1.0000 -2.0000

  • Min.Order :100 Kilogram
  • Purity: 99%
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

D-Mannose D-Mannose 3458-28-4

Quick Details

  • Appearance:white powder
  • Application:Pharm chemicals industry
  • PackAge:25KG/Drum
  • ProductionCapacity:20|Metric Ton|Month
  • Storage:2-8°C
  • Transportation:By air /Sea/ coruier

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Product information

D-Mannose Basic information
Description References
Product Name: D-Mannose
Synonyms: DL-allo-2,3,4,5,6-Pentahydroxy-hexanal;d-[1,2,3-13C3]Mannose;d-[1-12C]Mannose (13C depleted at C1);d-[1-13C:1-2H]Mannose;d-[1-18O]Mannose;d-[2,3,4,5,6-13C5]Mannose;d-[3,4-13C2]Mannose;d-[UL-12C6]Mannose (13C depleted)
CAS: 3458-28-4
MF: C6H12O6
MW: 180.16
EINECS: 222-392-4
Product Categories: Sugars, Carbohydrates & Glucosides;Carbohydrates;13C & 2H Sugars;Basic Sugars (Mono & Oligosaccharides);Biochemistry;Sugars;Dextrins、Sugar & Carbohydrates;Carbohydrates & Derivatives;carbohydrate
Mol File: 3458-28-4.mol
D-Mannose Structure
 
D-Mannose Chemical Properties
Melting point  133-140 °C(lit.)
alpha  14 º (589nm, c=10, H2O)
Boiling point  232.96°C (rough estimate)
density  1,539 g/cm3
refractive index  1.5730 (estimate)
storage temp.  room temp
solubility  H2O: 50 mg/mL
form  powder
pka 12.08(at 25℃)
color  White
optical activity [α]20/D +13.8±0.5°, 24 hr, c = 10% in H2O
Water Solubility  2480 g/L (17 ºC)
λmax λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.1
Sensitive  Hygroscopic
Merck  14,5747
BRN  1564373
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey WQZGKKKJIJFFOK-ATJJXCEKSA-N
CAS DataBase Reference 3458-28-4(CAS DataBase Reference)
NIST Chemistry Reference D-Mannose(3458-28-4)
EPA Substance Registry System D-Mannose (3458-28-4)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
WGK Germany  3
3
TSCA  Yes
HS Code  29400010
MSDS Information
Provider Language
D-(+)-Mannose English
ACROS English
SigmaAldrich English
ALFA English
 
D-Mannose Usage And Synthesis
Description D-Mannose is a nutritional supplement that can be found in cranberries, peaches, apples, other berries, and some plants. D-mannose is a sugar that has an important role in human metabolism, especially in the glycosylation of certain proteins. D-mannose functionalizes by the inhibition of bacterial adherence to uroepithelial cells.
More than 90 percent of recurrent urinary tract infections (UTIs) are caused by Escherichia coli (E. coli), which is normally found in the intestinal tract. The cell walls of each E. coli are covered with tiny fingerlike projections called fimbria. Mannose can bind to the lectin on the bacteria’s fimbria so that the bacteria can be effectively rinsed out by urination.
D-Mannose is by far the most effective supplement for both treatment and prevention of UTIs. And it is used for the treating carbohydrate-deficient glycoprotein syndrome, an inherited metabolic disorder.
References [1] #
[2] Bojana Kranjcˇec, Dino Papesˇ , Silvio Altarac (2013) D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial, World J Urol, 32, 79-84
Chemical Properties White crystalline powder
Uses D-Mannose is a carbohydrate that is important in the glycosylation of molecules in a variety of cellular processes. It is involved in N and O glycosylation of bovine why protein products, used in inf ant formulas. It is also responsible for the O-glycosylation of the T helper cell-derived cytokine interlukin-17A, an important cell-signaling molecule.
Uses It has been used in a study to assess the synthesis of a family of amphiphilic glycopolymers. It has also been used in a study to investigate the early detection of bronchiolitis obliterans after lung transplantation.
Uses D-mannose acts as an alternative energy source utilized by brain. It is used in the study of assessing the synthesis of amphiphilic glycopolymers and investigating early detection of bronchiolitis obliterans.It may be useful in the treatment of urinary tract infections (UTIs) and carbohydrate-deficient glycoprotein syndrome type 1b. It is also useful in the formation of glycan structure and glycosylation.
Application D-mannose is a simple sugar structurally related to glucose. It is absorbed slowly from the gastrointestinal tract, and then a large proportion of it is excreted into the urine.
D-(+)-Mannose has been used:
as a reference standard in monosaccharide analysis and quantification from sea squirts Ascidiella aspersa
as a medium component for the selection of P898012 sorgum seeds transfected with Agrobacterium
in segmented filamentous bacterium (SFB) medium supplement for culturing human cell lines
Mannose is an aldohexose carbohydrate. It is isomer of glucose with varying C2 position configuration. Majority of mannose is synthesised from its epimer glucose. It is part of the glycans present in endoplasmic reticulum (ER)/Golgi.
Definition ChEBI: D-Mannopyranose having alpha-configuration at the anomeric centre.
General Description

Mannose is a monosaccharide.

Biochem/physiol Actions Mannose, a six-carbon carbohydrate, is the C-2 epimer of glucose and a critical sugar for protein glycosylation. Mannose can also be utilized by the brain as an alternative energy source.
Source D-mannose is a sugar that can be found in some fruits and vegetables, such as oranges, apples, peaches, broccoli and green beans. It has been used in the past to treat UTIs in animals. Now, there is some interest into whether it could also treat and prevent UTI in humans.
D-mannose is a naturally occurring simple sugar that your body utilizes to help cleanse the urinary tract and maintain a healthy bladder lining. It’s metabolized only in small amounts, with excess amounts rapidly excreted in urine, so it won’t interfere with healthy blood sugar regulation. Clinical studies have demonstrated that, when taken regularly, D-mannose promotes normal urinary tract function by cleansing and maintaining the health of the bladder lining.
Purification Methods Crystallise -D(+)-mannose repeatedly from EtOH, aqueous 80% EtOH, AcOH or MeOH/propan-2-ol and then dry it in vacuo over P2O5 at 60o. [For 1H NMR and equilibr
 
D-Mannose Preparation Products And Raw materials
Raw materials D-Mannitol-->METHYL B-D-MANNOPYRANOSIDE ISOPROPYLATE-->METHYL-ALPHA-D-MANNOPYRANOSIDE
Preparation Products 5-Hydroxymethylfurfural-->Methyl levulinate-->BENZYL ALPHA-D-MANNOPYRANOSIDE-->1-5-ANHYDRO-D-MANNITOL CRYSTALLINE-->AMYL LACTATE-->δ-D-Mannonolactone-->GLYCOLALDEHYDE-->2,4-dihydroxy-Butanoic acid-->D(-)-Fructose-->Pyridoxine

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