Chymotrypsin Powder Bulk Quantity with Low Price

Details:

1. Introduction

Chymotrypsin powder is a proteolytic enzyme extracted from bovine pancreas. There are many kinds of chymotrypsin, in addition to α type, there are β, γ, δ, π, ε, etc., among which α type chymotrypsin is the most stable one.

 

2. Main Functions

2.1 Chymotrypsin can improve tissue permeability, inhibit inflammation, dissolve exudative and necrotic tissue, etc., thus improving acne symptoms. In some experiments, α-chymotrypsin 4000U + amikacin sulfate injection 2ml was injected into the cyst, and the total effective rate was 94.74%. Acne was treated by direct injection of α-chymotrypsin 5mg plus normal saline 2ml , 3 to 7 days as a course of treatment , 84 nodular cystic acnes were treated , 71 were cured and 13 were improved .

2.2 Treatment of infertility

At present, it has been found that there are many factors involved in the semen liquefaction process, of which enzymes are the most important, α-chymotrypsin is an endopeptidase, which can significantly shorten the semen liquefaction time and reduce its viscosity, but has no effect on sperm motility. obvious impact. The clinical trial used α-chymotrypsin combined with intrauterine insemination for the treatment of infertility. 114 times of artificial insemination were performed on 38 patients with infertility, and 23 cases were pregnant.

2.3 Treat ganglion cyst

Ganglion cyst is a cystic mass near the joint. There are many treatment methods. The traditional intracystic injection drug is hydrocortisone acetate, but it is easy to recur. The use of alpha-chymotrypsin in the treatment of ganglion cysts is mainly based on the action of alpha-chymotrypsin, a proteolytic enzyme that dissolves pus to thin it, dissolves blood clots and necrotic tissue, and eliminates cellulose caused by the inflammatory process Precipitation promotes the growth of granulation tissue, but has no effect on normal tissue.

 

2.4 Treat other diseases

It can also be used to treat many other diseases like chronic pharyngitis, pelvic inflammatory disease, lumbar disc herniation, herpetic stomatitis, severe pneumonia, chronic skin ulcers.

 

3. Applications

It is clinically used for wound healing after general trauma or surgery, anti-inflammatory, preventing local edema, blood accumulation, sprain hematoma, local swelling after breast surgery, otitis media, rhinitis, etc.; It is also used in combination with trypsin as a broad-spectrum anti-inflammatory drug. As an auxiliary drug for antibiotics and bactericidal drugs, it is widely used in animal medicine and animal health care.

               

             

4. Flow Chart

Bovine pancreas → leaching with sulfuric acid at 0°C → salting out of leaching solution → dissolving salted out in cold distilled water → adjusting pH with sulfuric acid → adjusting pH with ammonium sulfate and sodium hydroxide → crystallization → repeated dissolution → recrystallization → chymotrypsin Crystallization → activation → salting out → dialysis → drying → chymotrypsin

5. Quality Standard 

According to Enterprise Standard

Items	Specifications	Results
Appearance	White powder	White powder
Loss on drying	≤5.0%	3.0%
Redisue on ignition	≤5.0%	2.9%
Limit of Trypsin	No purple color develops within 3 minutes	Complies
Assay	≥300 USP units/mg (calculated on the dried basis)	310 USP u/g
Microbiological limits
Total Plate Count	≤1000cfu/g	<1000cfu/g
Total Yeast & Mold	≤100cfu/g	<100cfu/g
E.Coli.	Negative	Not detected
Salmonella	Negative	Not detected
Conclusion	The product complies with enterprise standard and USP standard.