Umifenovir Hydrochloride

Details:

1. Introduction

Umifenovir Hydrochloride is a dual-effect anti-influenza virus drug, which can fight influenza caused by influenza A and B viruses at the same time, and may also have antiviral activity against some other respiratory virus infections.

2. Main Functions

Compared with other antiviral drugs, Umifenovir Hydrochloride has the following characteristics:

1. Kills A and B influenza viruses at the same time.

2. Prevents virus fusion and replication.

3. Induces interferon and obviously improves self-immunity.

4. Significantly reduces flu symptoms and shorten the course of flu.

5. Prevents the occurrence and development of late flu syndrome.

6. Taking during influenza epidemic can effectively prevent influenza.

7. In vitro test, it has curative effect on SARS virus and avian influenza virus.

8. Convenient oral administration, high safety and good compliance.

3. Applications

Umifenovir Hydrochloride is used in medicine for adults and children with influenza A, influenza B, acute viral respiratory infections, severe acute respiratory disease syndrome, including the prevention and treatment of complicated bronchitis and pneumonia

4. Flow Chart

Using 3-iodo-4-nitrophenol as a raw material, the compound is prepared by the hydroxyl reaction with acetyl chloride→The compound is substituted with ethyl acetoacetate under the action of a base to prepare the compound→Compound is synthesized by reduction-condensation synergistic reaction under the condition of acetic acid and iron powder to synthesize indole ring to obtain compound→ Compound is prepared by N-methylation reaction with dimethyl sulfate→ Compound is obtained in In carbon tetrachloride, the compound is prepared by dibromination with bromine→The compound is reacted with thiophenol under alkaline conditions, and the compound is obtained after acidification; →The compound in the reaction solvent has dimethylamine In the presence of an aqueous solution of formaldehyde, the compound is prepared →The compound is acidified in hot acetone to obtain Arbidol hydrochloride