Fisetin Powder

Details:

1. Introduction

Fisetin powder cas 528-48-3 is a kind of natural flavonoid compound extracted from plants such as Anacardiaceae sycamore. It is also present in vegetables and fruits such as apples, persimmons, grapes, kiwi, strawberries, onions and cucumbers. It has antioxidant, anti-inflammatory and other pharmacological properties.

2. Main Functions

2.1.Anti-oxidation

Fisetin powder cas 528-48-3 is a bioflavonoid antioxidant that can help maintain glutathione levels and mitochondrial function in the presence of oxidative stress. It has the potential to cross the blood-brain barrier, which may help maintain neuronal function.

Fisetin can support the body's antioxidant pool by directly scavenging free radical activity and enhancing glutathione levels. In vitro studies have shown that fisetin can support glutathione, a very active antioxidant naturally present in the human body, by supplying cells with cysteine (a building block of glutathione) or by enhancing glutathione synthesis. glutathione. Fisetin may help regulate the production of many proteins involved in protecting the body from oxidative stress and maintaining redox homeostasis (the balance between the rate of free radical production and the rate of scavenging of various antioxidants).

2.2 Antitumor

In recent years, the role of fisetin in antitumor has attracted people's attention. Studies have shown that fisetin can exert anti-tumor effects by inducing tumor cell apoptosis, affecting tumor cell signal transduction pathways, inhibiting tumor cell proliferation, and inhibiting tumor cell migration and invasion.

Fisetin induces tumor cell apoptosis mainly by activating Caspase, down-regulating BIRC8 and Bcl2L2, and inhibiting COX-2.

The natural product fisetin can inhibit the growth and spread of tumor cells through various pathways. At the same time, fisetin has the characteristics of wide distribution in nature, less toxic and side effects, and multi-channel effects. Human health career services.

2.3 Anticancer effect

The researchers used the sumac extract containing fisetin, flavonoids, thioflavin and raspberry to compound the drug carrier to obtain a composition with anticancer activity. The activity experiment showed that the sumac extract has anti-human lung cancer. Cells, against uterine cancer cells, against human skin cancer cells and against human colon cancer cells. Its main mechanism is to induce the organ differentiation of cancer cells into normal cells by transforming cancer cell genes.

Fisetin is the most typical active substance in the flavonoids of fisetin, which can effectively inhibit the proliferation of prostate cancer cells and induce their apoptosis. In human lung cancer cells, fisetin can reduce the production of MMPs by inhibiting the MAP kinase and NF-κB pathways. And it can promote the proliferation of breast cancer, cervical cancer, blood cancer and other cells and promote apoptosis. Therefore, fisetin is considered as a potential anticancer agent.

 

3. Applications

Fisetin powder cas 528-48-3 is mainly used in healthcare products.

                     

4. Flow Chart

Cotinus chinensis dried branches and leaves → pulverized → soaking and extraction → extract filtration → pH adjustment → perforated resin adsorption → 60%-70% ethanol solution elution → eluate recovery under reduced pressure → crystallization → sodium carbonate solution dissolution → extraction → removal of organic phase → adjust pH → set aside for precipitation → recrystallization → drying → finished product

5. Quality Standard

Accoding to Enterprise Standard

Items	Specifications	Results
Appearance	Yellow fine powder	Yellow fine powder
Odor	Characteristic	Complies
Assay（HPLC）	Fisetin≥98%	98.10%
Loss on drying	≤5.0%	1.12%
Total ash	≤5.0%	0.73%
Heavy Metals	≤20ppm	<20ppm
Pb	≤2ppm	<2ppm
As	≤2ppm	<2ppm
Hg	≤0.1ppm	<0.1ppm
Cd	≤1ppm	<1ppm
Total Plate Count	≤1000cfu/g	<1000cfu/g
Total Yeast & Mold	≤100cfu/g	<100cfu/g
E.Coli.	Negative	Not detected
Salmonella	Negative	Not detected

 

6. Method of Analysis

MOA is available upon request

7. Reference Spectrum