China Biggest Facto...

China Biggest Factory manufacturer supply Hemin
China Biggest Factory manufacturer supply Hemin
China Biggest Factory manufacturer supply Hemin
China Biggest Factory manufacturer supply Hemin
China Biggest Factory manufacturer supply Hemin

China Biggest Factory manufacturer supply Hemin

Min.Order / FOB Price:Get Latest Price

50 Kilogram

FOB Price:USD 1.0000 -2.0000

  • Min.Order :50 Kilogram
  • Purity: 99%
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Hemin 16009-13-5 16009-13-5

Quick Details

  • Appearance:white powder
  • Application:Pharm chemicals industry
  • PackAge:25KG/Drum
  • ProductionCapacity:2|Metric Ton|Month
  • Storage:2-8°C
  • Transportation:By air /Sea/ coruier

Superiority:

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                                                   Our Factories R&D ability

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                                                                   Group profiles

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

Details:

 

Product information

Hemin Basic information
Product Name: Hemin
Synonyms: PROTOHEMIN IX;HEMATIN HYDROCHLORIDE;HEMIN;HEMIN, BOVINE;HEMIN CHLORIDE;HEMIN CHLORIDE BOVINE;HEMIN CHLORIDE PORCINE;HEMIN (EX PORCINE, BOVINE, EQUINE)
CAS: 16009-13-5
MF: C34H31ClFeN4O4-
MW: 650.94
EINECS: 240-140-1
Product Categories: organic amine;Organometallics;Biochemistry;Classes of Metal Compounds;Fe (Iron) Compounds;Transition Metal Compounds;Natural Porphyrins and Derivitives;Porphyrins
Mol File: 16009-13-5.mol
Hemin Structure
 
Hemin Chemical Properties
Melting point  300 °C
storage temp.  2-8°C
solubility  1.4 M NaOH: soluble25mg/mL
form  crystal
color  black
Water Solubility  practically insoluble
Merck  14,4644
BRN  5229914
Stability: Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKey BTIJJDXEELBZFS-HXFTUNQESA-K
EPA Substance Registry System Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24]-, dihydrogen, (SP-5-13)- (16009-13-5)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-22-36-26
WGK Germany  3
RTECS  LJ8080000
8
TSCA  Yes
HS Code  29349990
MSDS Information
Provider Language
Chloroprotoporphyrin IX iron(III) English
SigmaAldrich English
ACROS English
ALFA English
 
Hemin Usage And Synthesis
Chemical Properties Dark purple crystalline powder
Uses Identification of blood stains, biochemical research, complexing agent.
Uses Hemin is used in cellular protection and control mechanism. It stimulates the synthesis of globulin. It is also used to study the bacterial strains and growth conditions, in the short-term colony assays and cell transfections. Further, it is used to treat the symptoms of various porphyrias. In addition, it is used in the preparation of agar medium for the bacteria culture.
Uses Hemin is used for the following applications:
  • To study bacterial strains and growth conditions
  • Used in short-term colony assays (the culture medium consists of hemin along with other components)
  • Cell transfections
It may be used in β-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin.
General Description

Heme is a small molecule present either free or bound to hemoglobin in the bloodstream of mammals. This is an alternative source of iron within the host that contains a porphyrin ring containing a Fe2+ ion called hemin.

Biochem/physiol Actions Hemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders.Hemin may be used to study the expression and represson of heme oxygenase 1 (HO-1) as well as the activity of HO-1. Hematin is the "X factor" required to grown Haemophilus influenzae.
Purification Methods Hemin is purified by recrystallisation from AcOH. Also, hemin (5g) is shaken in pyridine (25mL) till it dissolves, then CHCl3 (40mL) is added, the container is stoppered and shaken for 5minutes (releasing the stopper occasionally). The solution is filtered under slight suction, and the flask and filter are washed with a little CHCl3 (15mL). During this period, AcOH (300mL) is heated to boiling, and saturated aqueous NaCl (5mL) and conc HCl (4mL) are added. The CHCl3 filtrate is poured in a steady stream, with stirring, into the hot AcOH mixture and set aside for 12hours. The crystals are filtered off, washed with 50% aqueous AcOH (50mL), H2O (100mL), EtOH (25mL), Et2O and dried in air. [Fischer Org Synth Coll Vol III 442 1955, Beilstein 26 III/IV 3048.]
 
Hemin Preparation Products And Raw materials
Raw materials Diethylamine-->Dichloroacetic acid-->Strontium chloride-->Cellulose-DEAE,DE 32
Preparation Products Hematoprophyrin-->HEMATOPORPHYRIN

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