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L-Cystine L-Cystine 56-89-3
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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research. Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products. Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation. We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.
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Product information
L-Cystine Basic information |
Product Name: | L-Cystine |
Synonyms: | (r-(r*,r*))-3,3’-dithiobis(2-aminopropanoicacid);1-cystine;3,3’-dithiobis(2-amino-,(r-(r*,r*))-propanoicaci;3,3’-dithiobis(2-aminopropanoicacid);3,3’-dithiobis-l-alanin;3,3'-Dithiobis(2-aminopropanoic acid);3,3'-Dithiodialanine;Alanine, 3,3'-dithiobis- |
CAS: | 56-89-3 |
MF: | C6H12N2O4S2 |
MW: | 240.3 |
EINECS: | 200-296-3 |
Product Categories: | Amino Acids;Cysteine [Cys, C];Food and Feed Additive;Amino Acids;Nutritional Supplements;L-Amino Acids;Amino Acid Derivatives;amino |
Mol File: | 56-89-3.mol |
L-Cystine Chemical Properties |
Melting point | >240 °C (dec.) (lit.) |
alpha | -224 º(c=2 in 1M HCl) |
Boiling point | 468.2±45.0 °C(Predicted) |
density | 1.68 |
refractive index | -222.5 ° (C=1, 1mol/L HCl) |
storage temp. | 2-8°C |
solubility | 1 M HCl: 100 mg/mL |
form | Powder/Solid |
pka | 1.0, 2.1, 8.02, 8.71(at 25℃) |
color | White |
optical activity | [α]20/D 219±5°, c = 1% in 1 M HCl |
Water Solubility | 0.112 g/L (25 ºC) |
Merck | 14,2782 |
BRN | 1728094 |
Stability: | Stable. Incompatible with strong oxidizing agents. |
InChIKey | LEVWYRKDKASIDU-IMJSIDKUSA-N |
CAS DataBase Reference | 56-89-3(CAS DataBase Reference) |
NIST Chemistry Reference | L-Cystine(56-89-3) |
EPA Substance Registry System | L-Cystine (56-89-3) |
Safety Information |
Hazard Codes | Xi,Xn |
Risk Statements | 36/37/38-22 |
Safety Statements | 26-36-24/25 |
RIDADR | 2811 |
WGK Germany | 3 |
RTECS | HA2690000 |
Hazard Note | Irritant |
TSCA | Yes |
PackingGroup | III |
HS Code | 29309014 |
MSDS Information |
Provider | Language |
---|---|
2-Amino-3-[(2-amino-2-carboxyethyl)dithio]propanoic acid | English |
ACROS | English |
SigmaAldrich | English |
ALFA | English |
L-Cystine Usage And Synthesis |
Description | L-cystine (formula: (SCH2CH(NH2) CO2H)2), the L-form of cystine) is a covalently linked dimeric nonessential amino acid formed through the oxidation of cysteine. It is contained in many foods including eggs, meat, dairy products, and whole grains as well as in skin and hairs. L-cystine and L-methionine are the amino-acids required for wound healing and formation of epithelial tissue. It is able to stimulate the hematopoietic system and promote the formation of white and red blood cells. It can also be used as a component of parental and enteral nutrition. It can also be used for the treatment of dermatitis and protection of liver function. L-cystine is manufactured through the enzymatic conversion from DL-amino thiazoline carboxylic acid. |
References | # # # |
Chemical Properties | A white or almost white, crystalline powder, practically insoluble in water and in alcohol. |
Uses | L-Cystine is a non-essential amino acid for human development. L-Cystine is formed by the dimerization of two cysteines through the sulfur. |
Uses | L-Cystine is used as an antioxidant, protecting tissues against radiation and pollution. It finds application in protein synthesis. It is required for utilization of vitamin B6 and is useful in healing burns and wounds. It is also is required by certain malignant cell lines in the culture medium as well as for the growth of certain micro-organisms. It is useful in the stimulation of hematopoietic system and promotes the formation of white and red blood cells. It is an active ingredient in medications used to treat dermatitis. |
Uses |
L-Cystine has been used in in vitro cystine solubility assay to identify potential drugs that influence cystine solubility. It is also used as a supplement of phosphate-buffered saline to slice and wash periprosthetic tissues. |
General Description |
This Standard Reference Material (SRM) is intended primarily for use in validating microchemical procedures for the determination of carbon, hydrogen, nitrogen, and sulfur in organic matter. SRM 143d is pure crystalline cystine supplied in a 2 g unit size. For more information, please refer to the SDS and COA. |
Biochem/physiol Actions | Cysteine is the source of disulfide linkages in proteins and has a role in sulfur transport. It undergoes rapid oxidation to form cystine at physiological pH. L-cystine is crucial for oxygen production and low density lipoprotein modification by arterial smooth muscle cells. It also has a role in the synthesis of glutathione. |
Safety Profile | Low toxicity by ingestion. When heated to decomposition it emits toxic fumes of PO, and SOx |
Purification Methods | Cystine disulfoxide impurity is removed by treating an aqueous suspension with H2S. The cystine is filtered off, washed with distilled water and dried at 100o under a vacuum over P2O5. Crystallise it by dissolving in 1.5M HCl, then adjusting to neutral pH with ammonia. Likely impurities are D-cystine, meso-cystine and tyrosine. Also purify it by dissolving it in 10% NH3 and adding gradually dilute AcOH until the point of precipitation and cooling slowly [Dughton & Harrison Acta Cryst 12 396, 402 1959.] Alternatively dissolve it in 6N NH4OH and evaporate it at room temperature for crystallisation to occur. [Chaney & Steinrauf Acta Cryst 30 711 1974, Beilstein 4 IV 3155.] |
L-Cystine Preparation Products And Raw materials |
Raw materials | Sodium hydroxide-->Hydrochloric acid-->Activated carbon-->Activated carbon,decolor-->Α-PROTEIN-->Ethylenediaminetetraacetic acid-->L(+)-Arginine-->L-Histidine-->Boc-D-Tyr-OH-->DL-Serine-->terylene-->N-CARBOBENZOXY-DL-LEUCINE-->SILK-->KERATIN |
Preparation Products | Cilastatin-->L-Cysteine-->L-Cysteine hydrochloride anhydrous-->L-Cysteine hydrochloride monohydrate-->DL-Cystine-->DIMETHYL CYSTINATE |
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