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China Biggest Factory manufacturer supply Carbomer 940

China Biggest Factory manufacturer supply Carbomer 940

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1 Kilogram

FOB Price:USD 1.0000 -2.0000

  • Min.Order :1 Kilogram
  • Purity: 99%
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Carbomer 940 9003-01-4 Carbomer 940

Quick Details

  • Appearance:white powder
  • Application:Pharm chemicals industry
  • PackAge:25KG/Drum
  • ProductionCapacity:200|Metric Ton|Month
  • Storage:2-8°C
  • Transportation:By air /Sea/ coruier

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                                PRODUCT DETAILS                           

Poly(acrylic acid) Basic information
Product Name: Poly(acrylic acid)
Synonyms: 940;Carbopol®;ACRYLIC ACID POLYMER;CARBOPOL(TM) 941;CARBOPOL(R) 940;CARBOPOL(TM) 940;CARBOPOL(TM) 934;CARBOPOL(TM) 910
CAS: 9003-01-4
MF: C5H10O2
MW: 102.1317
EINECS: 618-347-7
Product Categories: cosmetic;silicone oil;Acrylates: Poly(acrylic acid) and Related Polymers;Hydrophilic Polymers;Materials Science;Polymer Science;Industrial/Fine Chemicals;Polymer dispersant;Cnbio;Acrylates: Poly(acrylic acid) and Related Polymers;Acrylics;Hydrophilic Polymers;solvent;fine chemicals;Polymers;9003-01-4
Mol File: 9003-01-4.mol
Poly(acrylic acid) Structure
 
Poly(acrylic acid) Chemical Properties
Melting point  95 °C
Boiling point  116 °C
density  1.2 g/mL at 25 °C
refractive index  n20/D 1.442
Fp  100 °C
storage temp.  2-8°C
solubility  Swellable in water and glycerin and, after neutralization, in ethanol (95%). Carbomers do not dissolve but merely swell to a remarkable extent, since they are three-dimensionally crosslinked microgels.
form  Powder
color  White
Water Solubility  Soluble in water.
InChIKey WLAMNBDJUVNPJU-UHFFFAOYSA-N
IARC 3 (Vol. 19, Sup 7) 1987
EPA Substance Registry System Polyacrylic acid (9003-01-4)
 
Safety Information
Hazard Codes  C,T,Xi
Risk Statements  45-46-34-36/37/38
Safety Statements  53-45-36-27-26
WGK Germany  1
RTECS  AT4680000
TSCA  Yes
HS Code  39069090
Hazardous Substances Data 9003-01-4(Hazardous Substances Data)
Toxicity LD50 oral in rat: 2500mg/kg
MSDS Information
Provider Language
2-Propenoic acid homopolymer English
SigmaAldrich English
ACROS English
ALFA English
 
Poly(acrylic acid) Usage And Synthesis
Description Poly (acrylic acid) (PAA) is hygroscopic, brittle and colorless in nature with Tg at nearly 106oC. At temperatures above 200 to 250oC, it loses water and becomes an insoluble crosslinked polymer anhydride. Solubility of dried PAA in water increases with rise in temperatures. Concentrated solutions of PAA in water is thixotropic in nature.
Polyacrylic acid (PAA) is a hydrophilic colloidal solution, similar in properties to water-soluble natural gums. It is a clear, colorless, viscous stable solution. Applications include the modification of aqueous formulations for such end uses as cleaners, binders, adhesives, and emulsion paints. The sodium, potassium, and ammonium salts are effective thickeners and dispersants useful in both natural and synthetic latex systems. PAA in ceramic applications improves dry strength, dispersant action, and improved workability of the clays. PAA is stable to hydrolysis and is not susceptible to bacterial degradation.
Description For a description of unrelated compounds expanded by twocarbon units,Poly acrylic acid (PAA or Carbomer) is generic name for synthetic high molecular weight polymers of acrylic acid. They may be homopolymers of acrylic acid, crosslinked with an allyl ether pentaerythritol, allyl ether of sucrose or allyl ether of propylene. In a water solution at neutral pH, PAA is an anionic polymer, i.e. many of the side chains of PAA will lose their protons and acquire a negative charge. This makes PAAs polyelectrolytes, with the ability to absorb and retain water and swell to many times their original volume. Dry PAAs are found in the market as white and fluffy powders. Carbomer codes (910, 934, 940, 941 and 934P) are an indication of molecular weight and the specific components of the polymer. For many applications PAAs are used in form of alkali metal or amonium salts e.g. sodium polyacrylate.
Chemical Properties white powder
Chemical Properties Carbomers are white-colored, ‘fluffy’, acidic, hygroscopic powders with a characteristic slight odor. A granular carbomer is also available (Carbopol 71G).
Uses carboxypolymethylene is a binder, film-former and emulsion stabilizer. It can also help increase product viscosity.
Uses Applications of PAA may include: · to study solute diffusion in Polyvinyl alcohol/PAA copolymer hydrogel · synthesizing poly(N-isopropylacrylamide)-block-PAA copolymer which responds to both temperature and pH stimuli · in preparing block copolymer of oligo (methyl methacrylate)/PAA for micellar delivery of hydrophobic drugs · as thickening agent for adhesives
Uses Polyacrylic acid is used in disposable diapers and in ion exchange resins. It is also used to study solute diffusion in polyvinyl alcohol/polyacrylic acid copolymer hydrogel. It is also employed as a thickening, suspending, emulsifying and dispersing agent in pharmaceuticals, cosmetics, adhesives and paints. Further, it is used for the preparation of poly(N-isopropylacrylamide)-block-polyacrylic acid copolymer which responds to both temperature and pH stimuli. In addition to this, it is used in preparing block copolymer of oligo (methyl methacrylate)/PAA for micellar delivery of hydrophobic drugs.
Production Methods Carbomers are synthetic, high-molecular-weight, crosslinked polymers of acrylic acid. These acrylic acid polymers are crosslinked with allyl sucrose or allyl pentaerythritol. The polymerization solvent used previously was benzene; however, some of the newer commercially available grades of carbomer are manufactured using either ethyl acetate or a cyclohexane–ethyl acetate cosolvent mixture. The Carbopol ETD and Carbopol Ultrez polymers are produced in the cosolvent mixture with a proprietary polymerization aid.
Application Poly acrylic acid and its derivatives are used in disposable diapers,ion exchange resins and adhesives. They are also popular as a thickening, dispersing, suspending and emulsifying agents in pharmaceuticals, cosmetics and paints. PAA inactivates the antiseptic chlorhexidine gluconate.
Definition ChEBI: An acrylic macromolecule, composed of acrylic acid repeating units.
Brand name Carbopol 934 (Noveon).
General Description

Poly(acrylic acid) solution (PAA) is an anionic polymer that can be synthesized by the free radical polymerization of acrylic acid. It has a swelling nature that tends to absorb and retain the water. Its high ion exchange capacity makes it useful in the formation of membranes.

Pharmaceutical Applications Carbomers are used in liquid or semisolid pharmaceutical formulations as rheology modifiers. Formulations include creams, gels, lotions and ointments for use in ophthalmic, rectal, topical and vaginal preparations. Carbomer grades with residual benzene content greater than 2 ppm do not meet the specifications of the PhEur 6.4 monograph. However, carbomer having low residuals of other solvents than the ICH-defined ‘Class I OVI solvents’ may be used in Europe. Carbomer having low residuals of ethyl acetate, such as Carbopol 971P NF or Carbopol 974P NF, may be used in oral preparations, in suspensions, capsules or tablets. In tablet formulations, carbomers are used as controlled release agents and/or as binders. In contrast to linear polymers, higher viscosity does not result in slower drug release with carbomers. Lightly crosslinked carbomers (lower viscosity) are generally more efficient in controlling drug release than highly crosslinked carbomers (higher viscosity). In wet granulation processes, water, solvents or their mixtures can be used as the granulating fluid. The tackiness of the wet mass may be reduced by including talc in the formulation or by adding certain cationic species to the granulating fluid. However, the presence of cationic salts may accelerate drug release rates and reduce bioadhesive properties. Carbomer polymers have also been investigated in the preparation of sustained-release matrix beads, as enzyme inhibitors of intestinal proteases in peptide-containing dosage forms, as a bioadhesive for a cervical patch and for intranasally administered microspheres, in magnetic granules for site-specific drug delivery to the esophagus, and in oral mucoadhesive controlled drug delivery systems. Carbomers copolymers are also employed as emulsifying agents in the preparation of oil-in-water emulsions for external administration. Carbomer 951 has been investigated as a viscosity-increasing aid in the preparation of multiple emulsion microspheres. Carbomers are also used in cosmetics. Therapeutically, carbomer formulations have proved efficacious in improving symptoms of moderate-to-severe dry eye syndrome.
Safety Carbomers are used extensively in nonparenteral products, particularly topical liquid and semisolid preparations. Grades polymerized in ethyl acetate may also be used in oral formulations. There is no evidence of systemic absorption of carbomer polymers following oral administration. Acute oral toxicity studies in animals indicate that carbomer 934P has a low oral toxicity, with doses up to 8 g/kg being administered to dogs without fatalities occurring. Carbomers are generally regarded as essentially nontoxic and nonirritant materials; there is no evidence in humans of hypersensitivity reactions to carbomers used topically.
LD50 (guinea pig, oral): 2.5 g/kg for carbomer 934
LD50 (guinea pig, oral): 2.5 g/kg for carbomer 934P
LD50 (guinea pig, oral): 2.5 g/kg for carbomer 940
LD50 (mouse, IP): 0.04 g/kg for carbomer 934P
LD50 (mouse, IP): 0.04 g/kg for carbomer 940
LD50 (mouse, IV): 0.07 g/kg for carbomer 934P
LD50 (mouse, IV): 0.07 g/kg for carbomer 940
LD50 (mouse, oral): 4.6 g/kg for carbomer 934P
LD50 (mouse, oral): 4.6 g/kg for carbomer 934
LD50 (mouse, oral): 4.6 g/kg for carbomer 940
LD50 (rat, oral): 10.25 g/kg for carbomer 910
LD50 (rat, oral): 2.5 g/kg for carbomer 934P
LD50 (rat, oral): 4.1 g/kg for carbomer 934
LD50 (rat, oral): 2.5 g/kg for carbomer 940
LD50 (rat, oral): > 1g/kg for carbomer 941
No observed adverse effect level (NOAEL) (rat, dog, oral): 1.5 g/kg for carbomer homopolymer type B.
storage Carbomers are stable, hygroscopic materials that may be heated at temperatures below 1048℃ for up to 2 hours without affecting their thickening efficiency. However, exposure to excessive temperatures can result in discoloration and reduced stability. Complete decomposition occurs with heating for 30 minutes at 2608℃. Dry powder forms of carbomer do not support the growth of molds and fungi. In contrast, microorganisms grow well in unpreserved aqueous dispersions, and therefore an antimicrobial preservative such as 0.1% w/v chlorocresol, 0.18% w/v methylparaben–0.02% w/v propylparaben, or 0.1% w/v thimerosal should be added. The addition of certain antimicrobials, such as benzalkonium chloride or sodium benzoate, in high concentrations (0.1% w/v) can cause cloudiness and a reduction in viscosity of carbomer dispersions. Aqueous gels may be sterilized by autoclaving with minimal changes in viscosity or pH, provided care is taken to exclude oxygen from the system, or by gamma irradiation, although this technique may increase the viscosity of the formulation. At room temperature, carbomer dispersions maintain their viscosity during storage for prolonged periods. Similarly, dispersion viscosity is maintained, or only slightly reduced, at elevated storage temperatures if an antioxidant is included in the formulation or if the dispersion is stored protected from light. Exposure to light causes oxidation that is reflected in a decrease in dispersion viscosity. Stability to light may be improved by the addition of 0.05–0.1% w/v of a water-soluble UV absorber such as benzophenone-2 or benzophenone-4 in combination with 0.05–0.1% w/v edetic acid.
Carbomer powder should be stored in an airtight, corrosionresistant container and protected from moisture. The use of glass, plastic, or resin-lined containers is recommended for the storage of formulations containing carbomer.
Advantages The advantages of acrylic resins are :
Better stain protection (wash ability)
Water resistance
Better adhesion
Better blocking ('strap down')
Resist cracking and blistering better
Resistance to alkali cleaners.
Current market and forecast The global demand on acrylic resin approached roughly US $ 14.5 billion in 2011. With an annual growth rate of 4 - 5 % , the acrylic resin market is expected to reach US $ 16.6 billion by 2014 and US$22 billion by 2020. Acrylic resins are used in a wide range of applications for the outstanding chemical characteristics and unique aesthetic properties. Currently, the strongest demand comes from automotive and medical device markets, and paints & coatings, adhesive & sealant and construction & architecture are the major application markets for acrylic resin.
Formulae Acrylic resin is a general term for any one of the plastics (resin) generated through chemical reaction by applying polymerization initiator and heat to a monomer.
The chemical name for the resin produced from the methyl methacrylate monomer (MMA) is polymethyl methacrylate (PMMA). MMA is a transparent and colorless fluid substance.One of the main characteristic features of PMMA is its high transparency. With its high weather resistance, it has been known to last over 30 years, it does not easily turn yellow or crumble when exposed to sunlight. Polymethyl methacrylate is used not only for transparent windows in aquariums but also for various items such as signboards in places like convenience stores, taillights of automobiles, bathtub liners, sinks, cell phone display screens, backlight optical waveguides for liquid crystal displays (LCD) and so on.
Incompatibilities Carbomers are discolored by resorcinol and are incompatible with phenol, cationic polymers, strong acids, and high levels of electrolytes. Certain antimicrobial adjuvants should also be avoided or used at low levels. Trace levels of iron and other transition metals can catalytically degrade carbomer dispersions.
Certain amino-functional actives form complexes with carbomer; often this can be prevented by adjusting the pH of the dispersion and/or the solubility parameter by using appropriate alcohols and polyols.
Carbomers also form pH-dependent complexes with certain polymeric excipients. Adjustment of pH and/or solubility parameter can also work in this situation.
Regulatory Status Included in the FDA Inactive Ingredients Database (oral suspensions, tablets; ophthalmic, rectal, topical, transdermal preparations; vaginal suppositories). Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.
 
Poly(acrylic acid) Preparation Products And Raw materials
Raw materials Formic acid-->Benzoyl peroxide-->Methyl acrylate-->Acrylonitrile-->CARBON MONOXIDE-->Styrene-->2-Chloroethanol-->Acrylic acid-->Ammonium persulfate-->Acrylamide-->Acrolein-->Butyl acrylate-->6-Benzylaminopurine-->Methacrylic acid-->Ethyl acrylate-->Methyl methacrylate-->Sodium dodecyl sulfate-->3-Hydroxypropionitrile-->Butyl methacrylate-->2-Hydroxyethyl acrylate-->Methyl propiolate-->Hydroxypropyl acrylate-->Peregal OS-15-->Ferrophosphorus
Preparation Products Toluene-->Xylene-->Benzoyl peroxide-->Methyl acrylate-->Acrylonitrile-->Styrene-->Acrylic acid-->Acrylamide-->Butyl acrylate-->6-Benzylaminopurine-->Ethyl acrylate-->PAINT-->Sodium dodecyl sulfate-->Polyester resin paint-->L-(-)-Malic Acid-->conductive coating-->Automobile paint-->Acrylic latex paint for exterior wall-->Acrylic latex-->2-Hydroxyethyl acrylate-->Methyl propiolate-->ACRYLATES COPOLYMER-->efficient complex formulationof corrosion and scale control-->Motorcycle paint-->corrosion inhibitor WT-305-2-->6731 acrylic vibration damping coating-->DOX retanning agent-->polyhimic acid-->polymer flocculant TXY
 


                                Group profiles

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

 

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                                                       Product information

Poly(acrylic acid) Basic information
Product Name: Poly(acrylic acid)
Synonyms: 940;Carbopol®;ACRYLIC ACID POLYMER;CARBOPOL(TM) 941;CARBOPOL(R) 940;CARBOPOL(TM) 940;CARBOPOL(TM) 934;CARBOPOL(TM) 910
CAS: 9003-01-4
MF: C5H10O2
MW: 102.1317
EINECS: 618-347-7
Product Categories: cosmetic;silicone oil;Acrylates: Poly(acrylic acid) and Related Polymers;Hydrophilic Polymers;Materials Science;Polymer Science;Industrial/Fine Chemicals;Polymer dispersant;Cnbio;Acrylates: Poly(acrylic acid) and Related Polymers;Acrylics;Hydrophilic Polymers;solvent;fine chemicals;Polymers;9003-01-4
Mol File: 9003-01-4.mol
Poly(acrylic acid) Structure
 
Poly(acrylic acid) Chemical Properties
Melting point  95 °C
Boiling point  116 °C
density  1.2 g/mL at 25 °C
refractive index  n20/D 1.442
Fp  100 °C
storage temp.  2-8°C
solubility  Swellable in water and glycerin and, after neutralization, in ethanol (95%). Carbomers do not dissolve but merely swell to a remarkable extent, since they are three-dimensionally crosslinked microgels.
form  Powder
color  White
Water Solubility  Soluble in water.
InChIKey WLAMNBDJUVNPJU-UHFFFAOYSA-N
IARC 3 (Vol. 19, Sup 7) 1987
EPA Substance Registry System Polyacrylic acid (9003-01-4)
 
Safety Information
Hazard Codes  C,T,Xi
Risk Statements  45-46-34-36/37/38
Safety Statements  53-45-36-27-26
WGK Germany  1
RTECS  AT4680000
TSCA  Yes
HS Code  39069090
Hazardous Substances Data 9003-01-4(Hazardous Substances Data)
Toxicity LD50 oral in rat: 2500mg/kg
MSDS Information
Provider Language
2-Propenoic acid homopolymer English
SigmaAldrich English
ACROS English
ALFA English
 
Poly(acrylic acid) Usage And Synthesis
Description Poly (acrylic acid) (PAA) is hygroscopic, brittle and colorless in nature with Tg at nearly 106oC. At temperatures above 200 to 250oC, it loses water and becomes an insoluble crosslinked polymer anhydride. Solubility of dried PAA in water increases with rise in temperatures. Concentrated solutions of PAA in water is thixotropic in nature.
Polyacrylic acid (PAA) is a hydrophilic colloidal solution, similar in properties to water-soluble natural gums. It is a clear, colorless, viscous stable solution. Applications include the modification of aqueous formulations for such end uses as cleaners, binders, adhesives, and emulsion paints. The sodium, potassium, and ammonium salts are effective thickeners and dispersants useful in both natural and synthetic latex systems. PAA in ceramic applications improves dry strength, dispersant action, and improved workability of the clays. PAA is stable to hydrolysis and is not susceptible to bacterial degradation.
Description For a description of unrelated compounds expanded by twocarbon units,Poly acrylic acid (PAA or Carbomer) is generic name for synthetic high molecular weight polymers of acrylic acid. They may be homopolymers of acrylic acid, crosslinked with an allyl ether pentaerythritol, allyl ether of sucrose or allyl ether of propylene. In a water solution at neutral pH, PAA is an anionic polymer, i.e. many of the side chains of PAA will lose their protons and acquire a negative charge. This makes PAAs polyelectrolytes, with the ability to absorb and retain water and swell to many times their original volume. Dry PAAs are found in the market as white and fluffy powders. Carbomer codes (910, 934, 940, 941 and 934P) are an indication of molecular weight and the specific components of the polymer. For many applications PAAs are used in form of alkali metal or amonium salts e.g. sodium polyacrylate.
Chemical Properties white powder
Chemical Properties Carbomers are white-colored, ‘fluffy’, acidic, hygroscopic powders with a characteristic slight odor. A granular carbomer is also available (Carbopol 71G).
Uses carboxypolymethylene is a binder, film-former and emulsion stabilizer. It can also help increase product viscosity.
Uses Applications of PAA may include: · to study solute diffusion in Polyvinyl alcohol/PAA copolymer hydrogel · synthesizing poly(N-isopropylacrylamide)-block-PAA copolymer which responds to both temperature and pH stimuli · in preparing block copolymer of oligo (methyl methacrylate)/PAA for micellar delivery of hydrophobic drugs · as thickening agent for adhesives
Uses Polyacrylic acid is used in disposable diapers and in ion exchange resins. It is also used to study solute diffusion in polyvinyl alcohol/polyacrylic acid copolymer hydrogel. It is also employed as a thickening, suspending, emulsifying and dispersing agent in pharmaceuticals, cosmetics, adhesives and paints. Further, it is used for the preparation of poly(N-isopropylacrylamide)-block-polyacrylic acid copolymer which responds to both temperature and pH stimuli. In addition to this, it is used in preparing block copolymer of oligo (methyl methacrylate)/PAA for micellar delivery of hydrophobic drugs.
Production Methods Carbomers are synthetic, high-molecular-weight, crosslinked polymers of acrylic acid. These acrylic acid polymers are crosslinked with allyl sucrose or allyl pentaerythritol. The polymerization solvent used previously was benzene; however, some of the newer commercially available grades of carbomer are manufactured using either ethyl acetate or a cyclohexane–ethyl acetate cosolvent mixture. The Carbopol ETD and Carbopol Ultrez polymers are produced in the cosolvent mixture with a proprietary polymerization aid.
Application Poly acrylic acid and its derivatives are used in disposable diapers,ion exchange resins and adhesives. They are also popular as a thickening, dispersing, suspending and emulsifying agents in pharmaceuticals, cosmetics and paints. PAA inactivates the antiseptic chlorhexidine gluconate.
Definition ChEBI: An acrylic macromolecule, composed of acrylic acid repeating units.
Brand name Carbopol 934 (Noveon).
General Description

Poly(acrylic acid) solution (PAA) is an anionic polymer that can be synthesized by the free radical polymerization of acrylic acid. It has a swelling nature that tends to absorb and retain the water. Its high ion exchange capacity makes it useful in the formation of membranes.

Pharmaceutical Applications Carbomers are used in liquid or semisolid pharmaceutical formulations as rheology modifiers. Formulations include creams, gels, lotions and ointments for use in ophthalmic, rectal, topical and vaginal preparations. Carbomer grades with residual benzene content greater than 2 ppm do not meet the specifications of the PhEur 6.4 monograph. However, carbomer having low residuals of other solvents than the ICH-defined ‘Class I OVI solvents’ may be used in Europe. Carbomer having low residuals of ethyl acetate, such as Carbopol 971P NF or Carbopol 974P NF, may be used in oral preparations, in suspensions, capsules or tablets. In tablet formulations, carbomers are used as controlled release agents and/or as binders. In contrast to linear polymers, higher viscosity does not result in slower drug release with carbomers. Lightly crosslinked carbomers (lower viscosity) are generally more efficient in controlling drug release than highly crosslinked carbomers (higher viscosity). In wet granulation processes, water, solvents or their mixtures can be used as the granulating fluid. The tackiness of the wet mass may be reduced by including talc in the formulation or by adding certain cationic species to the granulating fluid. However, the presence of cationic salts may accelerate drug release rates and reduce bioadhesive properties. Carbomer polymers have also been investigated in the preparation of sustained-release matrix beads, as enzyme inhibitors of intestinal proteases in peptide-containing dosage forms, as a bioadhesive for a cervical patch and for intranasally administered microspheres, in magnetic granules for site-specific drug delivery to the esophagus, and in oral mucoadhesive controlled drug delivery systems. Carbomers copolymers are also employed as emulsifying agents in the preparation of oil-in-water emulsions for external administration. Carbomer 951 has been investigated as a viscosity-increasing aid in the preparation of multiple emulsion microspheres. Carbomers are also used in cosmetics. Therapeutically, carbomer formulations have proved efficacious in improving symptoms of moderate-to-severe dry eye syndrome.
Safety Carbomers are used extensively in nonparenteral products, particularly topical liquid and semisolid preparations. Grades polymerized in ethyl acetate may also be used in oral formulations. There is no evidence of systemic absorption of carbomer polymers following oral administration. Acute oral toxicity studies in animals indicate that carbomer 934P has a low oral toxicity, with doses up to 8 g/kg being administered to dogs without fatalities occurring. Carbomers are generally regarded as essentially nontoxic and nonirritant materials; there is no evidence in humans of hypersensitivity reactions to carbomers used topically.
LD50 (guinea pig, oral): 2.5 g/kg for carbomer 934
LD50 (guinea pig, oral): 2.5 g/kg for carbomer 934P
LD50 (guinea pig, oral): 2.5 g/kg for carbomer 940
LD50 (mouse, IP): 0.04 g/kg for carbomer 934P
LD50 (mouse, IP): 0.04 g/kg for carbomer 940
LD50 (mouse, IV): 0.07 g/kg for carbomer 934P
LD50 (mouse, IV): 0.07 g/kg for carbomer 940
LD50 (mouse, oral): 4.6 g/kg for carbomer 934P
LD50 (mouse, oral): 4.6 g/kg for carbomer 934
LD50 (mouse, oral): 4.6 g/kg for carbomer 940
LD50 (rat, oral): 10.25 g/kg for carbomer 910
LD50 (rat, oral): 2.5 g/kg for carbomer 934P
LD50 (rat, oral): 4.1 g/kg for carbomer 934
LD50 (rat, oral): 2.5 g/kg for carbomer 940
LD50 (rat, oral): > 1g/kg for carbomer 941
No observed adverse effect level (NOAEL) (rat, dog, oral): 1.5 g/kg for carbomer homopolymer type B.
storage Carbomers are stable, hygroscopic materials that may be heated at temperatures below 1048℃ for up to 2 hours without affecting their thickening efficiency. However, exposure to excessive temperatures can result in discoloration and reduced stability. Complete decomposition occurs with heating for 30 minutes at 2608℃. Dry powder forms of carbomer do not support the growth of molds and fungi. In contrast, microorganisms grow well in unpreserved aqueous dispersions, and therefore an antimicrobial preservative such as 0.1% w/v chlorocresol, 0.18% w/v methylparaben–0.02% w/v propylparaben, or 0.1% w/v thimerosal should be added. The addition of certain antimicrobials, such as benzalkonium chloride or sodium benzoate, in high concentrations (0.1% w/v) can cause cloudiness and a reduction in viscosity of carbomer dispersions. Aqueous gels may be sterilized by autoclaving with minimal changes in viscosity or pH, provided care is taken to exclude oxygen from the system, or by gamma irradiation, although this technique may increase the viscosity of the formulation. At room temperature, carbomer dispersions maintain their viscosity during storage for prolonged periods. Similarly, dispersion viscosity is maintained, or only slightly reduced, at elevated storage temperatures if an antioxidant is included in the formulation or if the dispersion is stored protected from light. Exposure to light causes oxidation that is reflected in a decrease in dispersion viscosity. Stability to light may be improved by the addition of 0.05–0.1% w/v of a water-soluble UV absorber such as benzophenone-2 or benzophenone-4 in combination with 0.05–0.1% w/v edetic acid.
Carbomer powder should be stored in an airtight, corrosionresistant container and protected from moisture. The use of glass, plastic, or resin-lined containers is recommended for the storage of formulations containing carbomer.
Advantages The advantages of acrylic resins are :
Better stain protection (wash ability)
Water resistance
Better adhesion
Better blocking ('strap down')
Resist cracking and blistering better
Resistance to alkali cleaners.
Current market and forecast The global demand on acrylic resin approached roughly US $ 14.5 billion in 2011. With an annual growth rate of 4 - 5 % , the acrylic resin market is expected to reach US $ 16.6 billion by 2014 and US$22 billion by 2020. Acrylic resins are used in a wide range of applications for the outstanding chemical characteristics and unique aesthetic properties. Currently, the strongest demand comes from automotive and medical device markets, and paints & coatings, adhesive & sealant and construction & architecture are the major application markets for acrylic resin.
Formulae Acrylic resin is a general term for any one of the plastics (resin) generated through chemical reaction by applying polymerization initiator and heat to a monomer.
The chemical name for the resin produced from the methyl methacrylate monomer (MMA) is polymethyl methacrylate (PMMA). MMA is a transparent and colorless fluid substance.One of the main characteristic features of PMMA is its high transparency. With its high weather resistance, it has been known to last over 30 years, it does not easily turn yellow or crumble when exposed to sunlight. Polymethyl methacrylate is used not only for transparent windows in aquariums but also for various items such as signboards in places like convenience stores, taillights of automobiles, bathtub liners, sinks, cell phone display screens, backlight optical waveguides for liquid crystal displays (LCD) and so on.
Incompatibilities Carbomers are discolored by resorcinol and are incompatible with phenol, cationic polymers, strong acids, and high levels of electrolytes. Certain antimicrobial adjuvants should also be avoided or used at low levels. Trace levels of iron and other transition metals can catalytically degrade carbomer dispersions.
Certain amino-functional actives form complexes with carbomer; often this can be prevented by adjusting the pH of the dispersion and/or the solubility parameter by using appropriate alcohols and polyols.
Carbomers also form pH-dependent complexes with certain polymeric excipients. Adjustment of pH and/or solubility parameter can also work in this situation.
Regulatory Status Included in the FDA Inactive Ingredients Database (oral suspensions, tablets; ophthalmic, rectal, topical, transdermal preparations; vaginal suppositories). Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.
 
Poly(acrylic acid) Preparation Products And Raw materials
Raw materials Formic acid-->Benzoyl peroxide-->Methyl acrylate-->Acrylonitrile-->CARBON MONOXIDE-->Styrene-->2-Chloroethanol-->Acrylic acid-->Ammonium persulfate-->Acrylamide-->Acrolein-->Butyl acrylate-->6-Benzylaminopurine-->Methacrylic acid-->Ethyl acrylate-->Methyl methacrylate-->Sodium dodecyl sulfate-->3-Hydroxypropionitrile-->Butyl methacrylate-->2-Hydroxyethyl acrylate-->Methyl propiolate-->Hydroxypropyl acrylate-->Peregal OS-15-->Ferrophosphorus
Preparation Products Toluene-->Xylene-->Benzoyl peroxide-->Methyl acrylate-->Acrylonitrile-->Styrene-->Acrylic acid-->Acrylamide-->Butyl acrylate-->6-Benzylaminopurine-->Ethyl acrylate-->PAINT-->Sodium dodecyl sulfate-->Polyester resin paint-->L-(-)-Malic Acid-->conductive coating-->Automobile paint-->Acrylic latex paint for exterior wall-->Acrylic latex-->2-Hydroxyethyl acrylate-->Methyl propiolate-->ACRYLATES COPOLYMER-->efficient complex formulationof corrosion and scale control-->Motorcycle paint-->corrosion inhibitor WT-305-2-->6731 acrylic vibration damping coating-->DOX retanning agent-->polyhimic acid-->polymer flocculant TXY

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