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Sodium fusidate Basic information Narrow-spectrum antibiotics Pharmacokinetics Adverse reactions and precautions Application Product Name: Sodium fusidate Synonyms: fucidina;fucidine;fusidatesodium;fusidin;fusin;intertullefucidin;Sodium fusidate reference substance;29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, monosodium salt, (3.alpha.,4.alpha.,8.alpha.,9.beta.,11.alpha.,13.alpha.,14.beta.,16.beta.,17Z)- CAS: 751-94-0 MF: C31H49NaO6 MW: 540.72 EINECS: 212-030-3 Product Categories: antibiotic;Organics Mol File: 751-94-0.mol   Sodium fusidate Chemical Properties Melting point  >200°C (dec.) storage temp.  Keep in dark place,Inert atmosphere,2-8°C solubility  H2O: soluble form  neat color  White to Off-White Water Solubility  Soluble in water Sensitive  Moisture & Light Sensitive Merck  13,4339 CAS DataBase Reference 751-94-0(CAS DataBase Reference)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-36/37/38 Safety Statements  26-36 WGK Germany  3 RTECS  LV5775000 HS Code  29419000 Toxicity LD50 in mice (g/kg): 0.2 i.v. (Godtfredsen, Nature 1962) MSDS Information Provider Language SigmaAldrich English   Sodium fusidate Usage And Synthesis Narrow-spectrum antibiotics Fusidic sodium mycophenolate sodium, also known as brown, fusidic sodium, having a steroid skeleton narrow-spectrum antibiotic, fusidic acid derivatives for the species, the appearance is white crystal or crystalline powder, odorless, bitter, slightly hygroscopic, soluble in water, ethanol, chloroform-soluble and insoluble in the acetone, ether, benzene. Danish LEO Pharma successfully developed the trade name Siding legislation for the first time, mainly in the liver metabolism, and by the excretion of bile, almost without going through the kidneys, low toxicity, have antiseptic effect by inhibiting bacterial protein synthesis. It has good antibacterial effect for gram-positive bacteria, it has good resistance. At the same time, this product is still sensitive for penicillin, methicillin antibiotic resistant strains such as, it has no cross resistance for husband sildenafil between sodium and other clinical use of antimicrobial agents. This product is non cephalosporins. There is no need to do skin allergy test. The current clinical treatment has been widely used by a variety of sensitive bacteria, especially Staphylococcus aureus caused by various infections, such as osteomyelitis, septicemia, endocarditis , recurrent infections of cystic fibrosis, myocardial bacterial meningitis, pneumonia, meningitis, diphtheria, tuberculosis, skin and soft tissue infections, surgical wound infections and the like. Intravenous medication is used for severe infection or resistant strains infection, also used for MRSA infection. But due to its easy resistance, much as auxiliary drug use. Oral treatment failure caused by clostridium pseudo membranous enteritis has fine effect. Pharmacokinetics Sodium fusidate(Fusidic acid) mainly works in the bacterial ribosome by inhibiting the displacement of the mRNA so as to block protein synthesis and sterilization. Good oral absorption, after a single oral dose of 0.5g 2h, Cmax about 14~38mg/L, 0.5g, 3 times/d, plasma concentration is up to 21~71mg/L in the 4th day. Drug-free savings, eating may affect the absorption. Intravenous infusion is 0.5g, 2h later, the plasma concentration is up to 40mg/L. High fat-soluble, tissue migration, and can penetrate into the aqueous humor, prostate, synovial fluid of the effective concentration; it can also smoothly go through the placenta, but it is difficult to penetrate the blood-brain barrier. Fusidic acid has excellent tissue penetration capability, which is widely distributed in the body. What is particularly important clinically is that this product is not only rich in high concentrations in the blood supply of tissues, It is known that the concentration of sodium fusidate exceeded the minimum inhibitory concentration for Staphylococcus (0.03 to 0.16 g/ml) in the pus, sputum, soft tissue, heart, bone tissue, synovial fluid, death of bone, burn eschar, brain abscess and intraocular. Fusidic sodium finishes its metabolism in the liver and is mainly excreted by the bile, hardly excreted by the kidneys. It has very low toxicity, and no cross allergy between other antimicrobial drugs in clinical use. Therefore it can be used to treat patients with contraindications to other antibiotics, such as penicillin or other antibiotics allergy. If serious and require prolonged treatment of deep infection. It is recommended that fusidic sodium associated with other anti-staphylococcal drugs can reduce drug resistance, It can obtain additive or synergistic effects result when associated with penicillin-resistant penicillins, cephalosporins, red vancomycin, aminoglycosides, clindamycin, rifampin or vancomycin. Adverse reactions and precautions Adverse reactions were mild and slight, and there were slight gastrointestinal reactions in the oral administration. Intravenous injection of product can lead to thrombophlebitis and venous spasm. Daily use of 1.5 to 3 grams of reversible would increase aminotransferase according to some reports. There have been reports of individual patients after treatment may appear retrograde jaundice, which is mainly seen in the high-dose intravenous administration, especially in patients with severe S. aureus bacteremia. If persistent jaundice, you should stop using the drug to make the serum bilirubin return to normal. Allergic reactions were rarely reported. Since the metabolism and excretion properties of fusidic sodium, when long-term large doses of medication or in combination with other fusidic sodium discharge pathway similar drugs (such as clindamycin or rifampicin), liver dysfunction and biliary abnormalities patients should regularly check liver function. In in vitro experiments, fusidic sodium may be substituted on the bilirubin albumin binding sites, such substitution clinical significance is unclear. It also did not discover the nuclear jaundices after using this product, but the premature children, jaundice, acidosis and severe sick newborns should pay attention to this factor when using this product. Application Fusidic sodiumproduce bactericidal effectby inhibiting bacterial protein synthesis,and having strong antibacterial effecton a range for Gram-positive bacteria. Staphylococcus aureus, including penicillin, methicillin and other antibiotics-resistant strains are highly sensitive to the chemicals. It has no cross-resistance between fusidic sodium and other antibacterial drugs in clinical use. Role: steroid skeleton antibiotic mainly has effect against Gram-positive bacteria and Neisseria, Mycobacterium tuberculosis antibacterial. It is used for surrounding infection caused by susceptible strains, especially suitable for resistant to other antibiotics. Commonly used in the skin bone parts, joint infections etc. Packaging: 25 kg per cardboard barrel. Description Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum. It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 μg/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus (MIC50s = >100 μg/ml for all). Fusidic acid inhibits ribosomal recycling and protein translocation, processes mediated by elongation factor G (EF-G), in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 μM, respectively). Topical administration of fusidic acid (2%) reduces the number of skin colony forming units (CFUs) and levels of TNF-α and IL-6 in a mouse model of methicillin-resistant S. aureus (MRSA) skin wound infection. Chemical Properties White or almost white, crystalline powder, slightly hygroscopic. Uses Antibacterial;Protein synthesis inhibitor GTPase coupled Uses Sodium fusidate is the more water soluble sodium salt of fusidic acid, a steriodal metabolite of Fusidum coccineum which is a potent Gram positive antibiotic. Fusidic acid inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Fusidic acid also suppresses NO lysis of pancreatic islet cells. Uses Sodium fusidate is the more water soluble sodium salt of fusidic acid, a steroidal metabolite of Fusidum coccineum which is a potent Gram positive antibiotic. Fusidic acid inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Fusidic acid also suppresses NO lysis of pancreatic islet cells. Brand name Fucidine (Bristol-Myers Squibb). General Description Fusidic acid is an antibiotic substance, resembling the structure of a steroid. It belongs to the class of fusidanes. Biochem/physiol Actions Fusidic acid possesses antimicrobial action against skin pathogens. It is highly specific to Staphylococcus aureus. It is therefore used for treating infected traumatic wounds, folliculitis, furunculosis, impetigo, erythrasma and abscesses. Clinical Use Antibacterial agent Drug interactions Potentially hazardous interactions with other drugs Antivirals: concentration of both drugs increased in combination with ritonavir and saquinavir - avoid with ritonavir. Statins: increased risk of myopathy with simvastatin and atorvastatin especially in diabetics. Avoid with simvastatin and for 7 days after last dose.1 Metabolism Fusidic acid is excreted in the bile, almost entirely as metabolites, some of which have weak antimicrobial activity. Approximately 2% appears unchanged in the faeces.   Sodium fusidate Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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