China Largest Manufacturer factory supply L(+)-Tartaric Acid CAS 87-69-4

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L(+)-Tartaric acid Basic information Product Name: L(+)-Tartaric acid Synonyms: FEMA 3044;DIHYDROXYSUCCINIC ACID;DEXTROTARTARIC ACID;ACIDUM TARTARICUM;2,3-DIHYDROXYDUTANEDIOIC ACID;2,3-DIHYDROXYBUTANEDIOIC ACID;(2R,3R)-(+)-TARTARIC ACID;(2R,3R)-2,3-DIHYDROXYSUCCINIC ACID CAS: 87-69-4 MF: C4H6O6 MW: 150.09 EINECS: 201-766-0 Product Categories: Food additive and acidulant;intermediates;Carboxylic Acids (Chiral);Amino Acids;Nutritional Supplements;Chiral Compound;Chiral Compounds;Chiral Building Blocks;for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry;VX:15689727968;87-69-4 Mol File: 87-69-4.mol   L(+)-Tartaric acid Chemical Properties Melting point  170-172 °C(lit.) alpha  12 º (c=20, H2O) Boiling point  191.59°C (rough estimate) density  1.76 vapor density  5.18 (vs air) vapor pressure  <5 Pa (20 °C) refractive index  12.5 ° (C=5, H2O) FEMA  3044 | TARTARIC ACID (D-, L-, DL-, MESO-) Fp  210 °C storage temp.  Store at +5°C to +30°C. solubility  H2O: soluble1M at 20°C, clear, colorless pka 2.98, 4.34(at 25℃) form  Solid color  White or colorless PH 3.18(1 mM solution);2.55(10 mM solution);2.01(100 mM solution); optical activity [α]20/D +13.5±0.5°, c = 10% in H2O Water Solubility  1390 g/L (20 ºC) Merck  14,9070 JECFA Number 621 BRN  1725147 Stability: Stable. Incompatible with oxidizing agents, bases, reducing agents. Combustible. InChIKey FEWJPZIEWOKRBE-JCYAYHJZSA-N CAS DataBase Reference 87-69-4(CAS DataBase Reference) NIST Chemistry Reference Butanedioic acid, 2,3-dihydroxy- [r-(r*,r*)]-(87-69-4) EPA Substance Registry System Tartaric acid (87-69-4)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38-41 Safety Statements  26-36-37/39-36/37/39 WGK Germany  3 RTECS  WW7875000 Autoignition Temperature 797 °F Hazard Note  Irritant TSCA  Yes HS Code  29181200 MSDS Information Provider Language L(+)-Dihydroxysuccinic acid English SigmaAldrich English ACROS English ALFA English   L(+)-Tartaric acid Usage And Synthesis Chemical Properties white crystals Chemical Properties Tartaric acid occurs as colorless monoclinic crystals, or a white or almost white crystalline powder. It is odorless, with an extremely tart taste. Uses L-(+)-Tartaric Acid is a naturally occurring chemical compound found in berries, grapes and various wines. It provides antioxidant properties and contributes to the sour taste within these products. Uses In the soft drink industry, confectionery products, bakery products, gelatin desserts, as an acidulant. In photography, tanning, ceramics, manufacture of tartrates. The common commercial esters are the diethyl and dibutyl derivatives used for lacquers and in textile printing. Pharmaceutic aid (buffering agent). Uses L-(+)-Tartaric acid is widely utilized in pharmaceutical industries. It is used in soft drinks, confectionaries, food products, gelatin desserts and as a buffering agent. It forms a compound, TiCl2(O-i-Pr)2 with Diels-Alder catalyst and acta as a chelate agent in metal industries. Owing to its efficient chelating property towards metal ions, it is used in farming and metal industries for complexing micronutrients and for cleaning metal surfaces, respectively. Definition ChEBI: A tetraric acid that is butanedioic acid substituted by hydroxy groups at positions 2 and 3. Production Methods Tartaric acid occurs naturally in many fruits as the free acid or in combination with calcium, magnesium, and potassium. Commercially, L-(＋)-tartaric acid is manufactured from potassium tartrate (cream of tartar), a by-product of wine making. Potassium tartrate is treated with hydrochloric acid, followed by the addition of a calcium salt to produce insoluble calcium tartrate. This precipitate is then removed by filtration and reacted with 70% sulfuric acid to yield tartaric acid and calcium sulfate. General Description Tartaric Acid belongs to the group of carboxylic acids, and is abundantly found in grapes and wine. It is widely used in drugs, food, and beverage industry. Pharmaceutical Applications Tartaric acid is used in beverages, confectionery, food products, and pharmaceutical formulations as an acidulant. It may also be used as a sequestering agent and as an antioxidant synergist. In pharmaceutical formulations, it is widely used in combination with bicarbonates, as the acid component of effervescent granules, powders, and tablets. Tartaric acid is also used to form molecular compounds (salts and cocrystals) with active pharmaceutical ingredients to improve physicochemical properties such as dissolution rate and solubility. Biochem/physiol Actions L-(+)-Tartaric acid serves as a donor ligand for biological processes. It is used as a food additive in candies and soft drinks to impart a sour taste. Safety Profile Moderately toxic by intravenous route. Mildly toxic by ingestion. Reaction with silver produces the unstable silver tartrate. When heated to decomposition it emits acrid smoke and irritating fumes. Safety Tartaric acid is widely used in food products and oral, topical, and parenteral pharmaceutical formulations. It is generally regarded as a nontoxic and nonirritant material; however, strong tartaric acid solutions are mildly irritant and if ingested undiluted may cause gastroenteritis. An acceptable daily intake for L-(＋)-tartaric acid has not been set by the WHO, although an acceptable daily intake of up to 30 mg/kg body-weight for monosodium L-(＋)-tartrate has been established. LD50 (mouse, IV): 0.49 g/kg storage The bulk material is stable and should be stored in a well-closed container in a cool, dry place. Incompatibilities Tartaric acid is incompatible with silver and reacts with metal carbonates and bicarbonates (a property exploited in effervescent preparations). Regulatory Status GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections; oral solutions, syrups and tablets; sublingual tablets; topical films; rectal and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.   L(+)-Tartaric acid Preparation Products And Raw materials Raw materials Hydrogen peroxide Preparation Products 5-Azaindole-->D-Tartaric acid-->Tri(o-tolyl)phosphine-->(R)-(-)-3-Quinuclidinol-->L-1-Phenylethylamine-->(R)-(+)-BORNYLAMINE-->(S)-1-Boc-3-(hyroxymethyl)piperidine-->(+)-(3R,4R)-BIS(DIPHENYLPHOSPHINO)-1-BENZYLPYRROLIDINE-->(+)-DIOP-->1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL--->(1S,2S)-(-)-1,2-Diphenyl-1,2-ethanediamine-->Levosulpiride-->(-)-(1S,4R)-4-AMINOCYCLOPENT-2-ENECARBOXYLIC ACID-->trans-2,5-Dimethylpiperazine-->2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol-->(R)-3-Quinuclidinol hydrochloride-->Ammonium L-tartrate-->Levamisole hydrochloride-->1H-Azepine-4-carboxylicacid,hexahydro-,methylester,(4R)-(9CI)-->(1R,2R)-(-)-1,2-Diaminocyclohexane-->(+)-Taddol-->(1S,2S)-(+)-1,2-Diaminocyclohexane-->METARAMINOL-->(1R,2R)-(+)-1,2-Diaminocyclohexane L-tartrate

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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