China Biggest Manufacturer factory sales USP/FCC/BP grade Zinc Gluconate CAS 4468-02-4

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                                PRODUCT DETAILS     

1.Chemical Name: Zinc Gluconate
2. Molecular Formula: C₁₂H₂₂ZnO₁₄ Anhydrous   C₁₂H₂₂ZnO₁₄· 2H₂O Dihydrate
3. Structural Formula:
4. Molecular Weight: 455.68 Anhydrous    491.71 Dihydrate
5. CAS No.: 4468-02-4 Dihydrate
6. Specification: USP/FCC/BP grade
7. Characters: Occurs as a white or nearly white, granular or crystalline powder and as a mixture of various states of hydration, up to the trihydrate, depending on the method of isolation. It is freely soluble in water and very slightly soluble in alcohol.
8. Application: Nutrient.
a. Critical to the body in small amount;
b. Important in the synthesis of nucleic acid, RNA and DNA;
c. Essential to the normal fuctioning of the reproductive system, particularly to the prostate and sperm production;
d. Used for centuries to speed the healing of woulds both internally and externally;
e. Enhances tasted bud acuity;
f. A component of insulin;
g. Protects liver from damage; h. Helps skin discorders;
i. Critical to protein synthesis; j. Aids digestion absorption and metabolism of vitamins;
k. Improtant in collagen foration and immune system function.
l. Zinc nutrition enhancer: Used in dairy products, baby and child foods, grain products and beverages, salt.
9. Package: Fiber drum or all paper drum or kraft paper bag, 25Kg net each
10. Storage: Stored in well-closed containers in a dry place at room temperature
11. Transportation: Handle with care in order to avoid damaging the package, protect them from sunshine or rain.

Zinc gluconate Basic information Organic zinc supplementation agent Uses Production method Identification test Content analysis Usage limit Chemical properties Toxicity Product Name: Zinc gluconate Synonyms: bis(d-gluconato-o(1),o(2))-zin;bis(d-gluconato-o(sup1),o(sup2))-zin;bis(d-gluconato-o(sup1),o(sup2))zinc;bis(d-gluconato-o1,o2)-zin;bis(D-gluconato-κO1,κO2)-,(T-4)-Zinc;rubozine;Zinegluconate;ZINC GLUCONATE CAS: 4468-02-4 MF: C12H22O14Zn MW: 455.68 EINECS: 224-736-9 Product Categories: Organometallics;Miscellaneous Biochemicals;Biochemistry;Classes of Metal Compounds;Glucose;Sugar Acids;Sugars;Transition Metal Compounds;Zn (Zinc) Compounds;Zinc Mol File: 4468-02-4.mol   Zinc gluconate Chemical Properties Melting point  172-175 °C Boiling point  319°C solubility  Soluble in water, practically insoluble in anhydrous ethanol and in methylene chloride. Water Solubility  Soluble in water 100g/ l. Merck  14,4456 CAS DataBase Reference 4468-02-4(CAS DataBase Reference) EPA Substance Registry System Zinc, bis(D-gluconato-.kappa.O1,.kappa.O2)-, (T-4)- (4468-02-4)   Safety Information RTECS  ZH3750000 TSCA  Yes HS Code  29181600 Hazardous Substances Data 4468-02-4(Hazardous Substances Data) MSDS Information Provider Language Zinc gluconate English ALFA English   Zinc gluconate Usage And Synthesis Organic zinc supplementation agent Zinc can activate a variety of important antioxidant enzymes, thereby eliminating the damage of oxygen free radicals, maintaining the normal permeability of the cell membrane to protect the normal biochemical composition of cell membranes, metabolic structure and function. Zinc can not only induce the activation of T lymphocyte but also activate the B lymphocytes. Zinc is also involved in antibody formation and release, and stimulating immune cells to secrete a variety of cytokines. Lack of zinc in elderly people can cause immune function disorder; zinc can affect the synthesis of insulin, secretion, storage, degradation and biological activity, being the major trace amount element directly affecting the insulin physiology. Zinc can improve the body's sensitivity to insulin. Zinc gluconate is an organic zinc supplement with fewer side effects than zinc sulfate and better absorption as well. It has certain efficacy on the treatment of zinc deficiency caused growth retardation, malnutrition, anorexia, recurrent oral ulcers, acne and senile zinc deficiency as well as immune dysfunction. It is mainly absorbed in the small intestine after oral administration with 1h reaching the peak but declining at about 2h. In the body, it is widely distributed in the liver, intestine, spleen, pancreas, heart, kidney, lung, muscle, central nervous system and bone. It is mainly excreted by the feces with a small amount excreted through the urine and milk. The bioavailability of it is about 1.6 times as high as that of zinc sulfate. This product can be used to delay aging, enhance immune response, treatment of non-insulin-dependent diabetes. Oral administration amount calculated on zinc element is 10~25 mg 2 times per day and administrated after meals. Adverse reactions after meal mainly include stomach discomfort, nausea, vomiting. Zinc gluconate should not be subject to fasting medication and should not be overdosed which can affect the absorption of iron. Uses Zinc gluconate is an excellent nutrient zinc enhancer, having significant effect for the intellectual and physiological development of infants and young people with its absorption effect being better than inorganic zinc. China provides that it can be used for salt with the usage amount of 800~1000mg/kg; 230~470mg/kg in dairy product; 195~545mg/kg in infant and child food; in cereals and their products: 160~320mg/kg; 40 to 80 mg/kg in beverages and milk beverages. Production method There are many routes of synthesis of gluconate zinc with reasonable ways including fermentation, air catalytic oxidation and calcium gluconate indirect synthesis. Fermentation Take glucose as raw materials with Aspergillus fermentation (oxidation) to generate into gluconic acid. After separation, purification, gluconate is neutralized by zinc oxide or zinc hydroxide for preparation of zinc gluconate. C6H12O6 + O2 [Aspergillus niger] → C6H11O6OH [ZnO] → (C6H11O6O) 2Zn + H2O The method is mainly used domestically and abroad, the reaction is simple; easy to get raw materials; low cost, but the fermentation process requires a higher technology. Air catalytic oxidation method Under the presence of the catalyst, the glucose is oxidized by air to produce gluconic acid; and then the sodium hydroxide solution is added dropwise to until the pH value reaches 9.0 to 10.0 so as to be converted into sodium gluconate; after filtering and separating the catalyst, the sodium gluconate solution is oxidized by strong acid cations exchange resin into high-purity gluconic acid solution; finally reacted with zinc oxide or zinc hydroxide to form zinc gluconate with concentration, crystallization and re-crystallization to obtain the product with the yield being over 80%. C6H12O6 + O2 [catalyst] → C6H11O6OH [NaOH] → C6H11O6ONa + H2O C6H11O6Ona [R-H] → C6H11O6OH [ZnO] → (C6H11O6O) 2Zn + H2O The method is easy to obtain raw materials with low cost and good product quality. Indirect synthesis from calcium gluconate Calcium gluconate, after being acidified by sulfuric acid is filtered to remove calcium sulfate precipitate to generate gluconic acid solution, which after being purified by ion exchange resin, has reaction with zinc oxide or zinc hydroxide to generate zinc gluconate; further carry out filtration, crystallization and drying to get the finished product. (C6H11O6O) 2Ca [H2SO4] → C6H11O6OH [ZnO] → (C6H11O6O) 2Zn + H2O Add 27 mL (0.5 mol) concentrated sulfuric acid to 500 mL water; successively add 224 g (0.5 mo1) of calcium gluconate and the reaction was carried out at 90 ° C for 1.5 h. The calcium sulfate precipitate was filtered off to give a pale yellow liquid. After cooling, the liquid flowed at a flow rate corresponding to resin volume per minute through the exchange column equipped with the same amount of anion and cation exchange resin to obtain a colorless transparent gluconic acid solution with the relative density of 1.10 to 1.12. The content is 20% and the yield is 95%. Take 0.1 mol of gluconic acid solution, and separately add 4.1 g (0.05 mol) of zinc oxide for reaction at 60 ° C for 2 hours. Add drop wise of gluconate liquid to pH=5.7 at the same time and concentrate the 1/3 the volume of the original volume. Add 10 mL 95% ethanol and stand 8 h. The product was purified by crystallization, separation and vacuum drying to obtain 21.8 g product with a 96% yield and purity of 99.3%. It can be obtained through the neutralization between zinc oxide and gluconic acid. Identification test The zinc test (IT-33) of the 10% sample liquid was positive. Take 5 mL of 10% warm sample solution; add 0.7 ml acetic acid and 1 ml new distillated phenylhydrazine for heating in the steam bath for 30min, let it cool. Scratch the inner wall of container with glass rod and it should produce gluconic acid phenylhydrazine crystals. Content analysis Weigh approximately 700 mg of the sample, dissolve it in 100 ml of water (heat if necessary); add 5 ml of ammonia-ammonium chloride buffer solution (TS-12) and 0.1 ml of wool chromium black test solution (TS-97). Apply 0.05mol/L of EDTA disodium titration solution for titration to blue color. Each mL of 0.05 mL/L of EDTA disodium corresponds to 22.78 mg of zinc gluconate (C12H22O14Zn). Usage limit GB 14880-94 (mg/kg): dairy products 230~470; infant food 195~545; cereals and their products, beverages 80~160; salt: 500. FDA, §182.5988 (2000): take GMP as limit. GB 2760-2000: soft drinks 21.0~56mg/kg; children over one year old and children milk powder, 0.05~1.175g/kg (all in Zn). According to the provisions of Japan, it is allowed to be used in breast milk substitute. The zinc content in per liter of standard milk concentration of breast milk substitute shall not exceed 6mg. Chemical properties It appears as white particles or crystalline powder with its molecule either containing or not containing three molecules of crystal water, being odorless and tasteless. It is easily soluble in water and slightly soluble in ethanol. Female mice by oral have a LD50 of 1.93g/k; male mice through oral have a LD50 of 2.99g/kg. Toxicity GRAS (FDA, § 182.8988, 2000); LD50 3.06 g/kg (mouse, oral); Chemical Properties White or almost white, hygroscopic, crystalline powder. Uses zinc gluconate helps maintain the skin in good condition and acts as a deodorant by preventing the growth of micro-organisms, such as bacteria, fungi or yeast, in a formulation. Zinc gluconate could also be effectively used in anti-acne products. Uses Chelating agent. In high alkalinity bottle washes and other cleansers; in finish removers; in the tanning and textile industry. Uses Zinc gluconate hydrate is used as a food additive, a pharmaceutical intermediate. Biotechnological Applications Zinc gluconate is the most common standalone zinc supplement and is used in zinc lozenges, which are discussed later. In one study, the use of a zinc tolerance test shows zinc gluconate to be better absorbed than zinc sulfate. It can also be noted that zinc gluconate has given positive results in a number of supplementation studies, including some done for malnutrition situations. On the other hand, in a small unpublished study from this author, zinc gluconate was very ineffective at raising plasma zinc, while a zinc amino acid chelate raised plasma zinc in all subjects tested. In addition, in a rat supplementation study, neither zinc gluconate nor zinc sulfate was as effective as a zinc–amino acid chelate in protecting against chemically induced oxidant damage. Thus, zinc gluconate seems to be a good source of zinc for many purposes, though in some applications, it may not be the absolute best source. Safety Profile Experimental reproductive effects. W'hen heated to decomposition it emits toxic fumes of ZnO.   Zinc gluconate Preparation Products And Raw materials Raw materials Water-->Zinc oxide-->Calcium gluconate-->Zinc hydroxide-->Gluconic acid-->Sodium gluconate-->strongly acidic type cation exchange resin

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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