China Biggest Manufacturer factory sales Ethyl Vanillin CAS 121-32-4

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Ethyl vanillin Basic information Overview Product Name: Ethyl vanillin Synonyms: 3-ethoxy-;3-Ethoxy-4-hydroxybenzaldehyd;3-ethoxy-4-hydroxy-benzaldehyd;4-Hydroxy-3-ethoxybenzaldehyde;Benzaldehyde, 3-ethoxy-4-hydroxy-;Benzaldehyde,3-ethoxy-4-hydroxy-;Ethavan;ethvlvanillin CAS: 121-32-4 MF: C9H10O3 MW: 166.17 EINECS: 204-464-7 Product Categories: Flavor;Food Additives;Pharmaceutical Raw Materials;Food and Feed Additive;Food & Feed ADDITIVES;Aromatic Aldehydes & Derivatives (substituted);VX:15689727968 Mol File: 121-32-4.mol   Ethyl vanillin Chemical Properties Melting point  74-77 °C (lit.) Boiling point  285°C density  1.1097 (rough estimate) vapor pressure  <0.01 mm Hg ( 25 °C) FEMA  2464 | ETHYL VANILLIN refractive index  1.4500 (estimate) Fp  127°C storage temp.  Store below +30°C. solubility  2.82g/l pka 7.91±0.18(Predicted) form  Fine Crystalline Powder color  White to off-white Water Solubility  slightly soluble Sensitive  Light Sensitive Merck  14,3859 JECFA Number 893 BRN  1073761 Stability: Hygroscopic CAS DataBase Reference 121-32-4(CAS DataBase Reference) NIST Chemistry Reference 3-Ethoxy-4-hydroxybenzadehyde(121-32-4) EPA Substance Registry System Ethyl vanillin (121-32-4)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-36/37/38 Safety Statements  26-36 WGK Germany  1 RTECS  CU6125000 Hazard Note  Harmful/Irritant/Light Sensitive TSCA  Yes HS Code  29124200 Hazardous Substances Data 121-32-4(Hazardous Substances Data) Toxicity LD50 orally in rats: >2000 mg/kg, P. M. Jenner et al., Food Cosmet. Toxicol. 2, 327 (1964) MSDS Information Provider Language 3-Ethoxy-4-hydroxybenzaldehyde English SigmaAldrich English ACROS English ALFA English   Ethyl vanillin Usage And Synthesis Overview Vanillin (4-hydroxy-3-methoxybenzaldehyde) is the primary chemical component of the extract of vanilla bean. Natural vanilla extract is a mixture of several hundred compounds in addition to vanillin. Artificial vanilla flavoring solution of pure vanillin, is usually of synthetic origin. Synthetic vanillin and ethyl vanillin are used as flavoring agents in foods, beverages, and pharmaceuticals. Ethyl vanillin (3-ethoxy-4-hydroxybenzaldehyde; EVA, Fig. 1) is more expensive and has a stronger flavor. Compared to vanillin, ethyl vanillin has an ethoxy group (-O-CH2CH3) rather than a methoxy group (-O-CH3). The largest single use of ethyl vanillin is for flavoring. It is first synthesized from eugenol found in oil of clove and afterward synthesized from lignincontaining sulfite liquor, a by-product of wood pulp processing in paper manufacture. While some ethyl vanillin is still made from lignin waste, today most synthetic vanillin is synthesized in a two-step process from the petrochemical precursors: vanillin, ethyl vanillin, and guaiacol and, glyoxylic acid. Vanilla, being the world’s most popular flavoring materials, finds extensive applications in food, beverages, perfumery and pharmaceutical industry. With the high demand and limited supply of vanilla pods and the continuing increase in their cost, numerous efforts of blending and adulteration in natural vanilla extracts have been reported. Ethyl vanillin and vanillin, the major phenolic constituents in vanilla products, are widely used as flavoring agents in foods and beverages. Ethyl vanillin, also used as a synthetic compound, is 2.5 times stronger in flavor than vanillin and used to substitute a large amount of vanillin, since it is less expensive and keeps better in storage and transport. Ethyl vanillin is converted to 3-ethoxy4-hydroxybenzaldehyde and 3-ethoxy-4-hydroxymandelic acid after dietary intake[1]. Chemical Properties WHITE TO OFF-WHITE FINE CRYSTALLINE POWDER Chemical Properties White or slightly yellowish crystals with a characteristic intense vanilla odor and flavor. Chemical Properties Its odor resembles that of vanillin but is approximately three times as strong. Ethylvanillin can be prepared by method 2 as described for vanillin, using guethol instead of guaiacol as the starting material. Chemical Properties Ethyl vanillin has an intense vanilla odor and sweet taste. The flavoring power is two to four times stronger than vanillin. Ethyl vanillin has been used in food since the 1930s; it enhances fruity and chocolate odor impression. Its addition is self-limiting, as too high a level may impart an unpleasant flavor in the product; the product is not stable. In contact with iron or alkali, it exhibits a red color and loses its flavoring power. Occurrence Not reported found in nature; it can be distinguished from vanillin because of the yellow color developed in the presence of concentrated H2SO4. Uses Ethyl Vanillin, is used as a flavorant, which is about three times as potent as vanillin (V097500) and can be utilized in the production of chocolate. It has also shown to have antioxidant properties. Uses Ethyl Vanillin is a flavoring agent that is a synthetic vanilla flavor with approximately three and one-half times the flavoring power of vanillin. it has a solubility of 1 g in 100 ml of water at 50°c. it is used in ice cream, beverages, and baked goods. Uses In flavoring and perfumery. Definition ChEBI: A member of the class of benzaldehydes that is vanillin in which the methoxy group is replaced by an ethoxy group. Production Methods Unlike vanillin, ethyl vanillin does not occur naturally. It may be prepared synthetically by the same methods as vanillin, using guethol instead of guaiacol as a starting material; see Vanillin. Preparation From safrole by isomerization to isosafrole and subsequent oxidation to piperonal; the methylene linkage is then broken by heating piperonal in an alcoholic solution of KOH; finally the resulting protocatechualdehyde is reacted with ethyl alcohol. From guaethol by condensation with chloral to yield 3-ethoxy-4-hydroxyphenyl trichloromethyl carbinol; this is then boiled with an alcoholic solution of KOH or NaOH, acidified, and extracted with chloroform to yield ethyl vanillin. Aroma threshold values Detection: 100 ppb; recognition: 2 ppm Taste threshold values Taste characteristics at 50 ppm: sweet, creamy, vanilla, smooth and caramellic. Synthesis Reference(s) The Journal of Organic Chemistry, 44, p. 3305, 1979 DOI: 10.1021/jo01333a006 General Description Colorless crystals. More intense vanilla odor and taste than vanillin. Air & Water Reactions Slightly water soluble . Reactivity Profile Protect from light. Aldehydes are readily oxidized to give carboxylic acids. Flammable and/or toxic gases are generated by the combination of aldehydes with azo, diazo compounds, dithiocarbamates, nitrides, and strong reducing agents. Aldehydes can react with air to give first peroxo acids, and ultimately carboxylic acids. These autoxidation reactions are activated by light, catalyzed by salts of transition metals, and are autocatalytic (catalyzed by the products of the reaction). The addition of stabilizers (antioxidants) to shipments of aldehydes retards autoxidation. Health Hazard ACUTE/CHRONIC HAZARDS: Toxic. May cause irritation on contact. Fire Hazard Combustible Pharmaceutical Applications Ethyl vanillin is used as an alternative to vanillin, i.e. as a flavoring agent in foods, beverages, confectionery, and pharmaceuticals. It is also used in perfumery. Ethyl vanillin possesses a flavor and odor approximately three times as intense as vanillin; hence the quantity of material necessary to produce an equivalent vanilla flavor may be reduced, causing less discoloration to a formulation and potential savings in material costs. However, exceeding certain concentration limits may impart an unpleasant, slightly bitter taste to a product due to the intensity of the ethyl vanillin flavor. Safety Profile Moderately toxic by ingestion, intraperitoneal, subcutaneous, and intravenous routes. A human skin irritant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also ALDEHYDES and ETHERS. Safety Ethyl vanillin is generally regarded as an essentially nontoxic and nonirritant material. However, cross-sensitization with other structurally similar molecules may occur. The WHO has allocated an acceptable daily intake for ethyl vanillin of up to 3 mg/kg body-weight. LD50 (guinea pig, IP): 1.14 g/kg LD50 (mouse, IP): 0.75 g/kg LD50 (rabbit, oral): 3 g/kg LD50 (rabbit, SC): 2.5 g/kg LD50 (rat, oral): 1.59 g/kg LD50 (rat, SC): 3.5–4.0 g/kg storage Store in a well-closed container, protected from light, in a cool, dry place. See Vanillin for further information. Incompatibilities Ethyl vanillin is unstable in contact with iron or steel, forming a redcolored, flavorless compound. In aqueous media with neomycin sulfate or succinylsulfathiazole, tablets of ethyl vanillin produced a yellow color. See Vanillin for other potential incompatibilities. Regulatory Status GRAS listed. Included in the FDA Inactive Ingredients Database (oral capsules, suspensions, and syrups). Included in nonparenteral medicines licensed in the UK.   Ethyl vanillin Preparation Products And Raw materials Raw materials Ethanol-->Sodium hydroxide-->Chloroform-->Hexamethylenetetramine-->Pyrocatechol-->Chloral-->Potassium hydroxide solution-->Cupric oxide-->Glyoxylic acid-->Sodium 3-nitrobenzenesulphonate-->1,3-Benzodioxole-->ISOEUGENOL-->Safrole-->DIMETHYLANILINE-->Ethylsulphuric acid-->N,N-DIMETHYL-4-NITROSOANILINE-->PROPENYL GUAETHOL-->Hydrogen peroxide 30% water solution-->2-Ethoxyphenol

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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