China Biggest Manufacturer factory sales Adenosine 5'-monophosphate CAS 61-19-8

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Adenosine 5'-monophosphate Basic information Chemical Properties Applications Preparation Usage restriction Category Toxicity Grading Acute Toxicity Flammability Hazardous Characteristics Storage and Transport Extinguishing Agent Product Name: Adenosine 5'-monophosphate Synonyms: a5mp;adenosine,mono(dihydrogenphosphate)(ester);Adenosine -5'- Monophosphate（AMP-H）;)-monophosphate disodium salt (mixed isomers);4-PREGNEN-18-OL, 3, 20-DIONE (20αOLS) 18, 20-HEMIKETAL;3-Hydroxy Tibolone-d5 |(mixture of 3αadenosine5’-phosphate CAS: 61-19-8 MF: C10H14N5O7P MW: 347.22 EINECS: 200-500-0 Product Categories: Nucleic acids;Pharmaceutical Intermediates;Organic acids;Heterocyclic Compounds;Biochemistry;Nucleosides, Nucleotides & Related Reagents;Nucleotides and their analogs;ZADITOR;BEAUTY PEPTIDES;Inhibitors;Pharmaceutical Mol File: 61-19-8.mol   Adenosine 5'-monophosphate Chemical Properties Melting point  178-185 °C Boiling point  798.5±70.0 °C(Predicted) density  2.32±0.1 g/cm3(Predicted) FEMA  4224 | ADENOSINE MONOPHOSPHATE; MONOSODIUM, OR DISODIUM ADENYLATE storage temp.  Keep in dark place,Inert atmosphere,Room temperature solubility  H2O: with addition of mild alkalisoluble pka 3.8, 6.2(at 25℃) form  Crystalline Powder color  Colorless to white Water Solubility  Soluble in water. Merck  14,158 CAS DataBase Reference 61-19-8(CAS DataBase Reference) EPA Substance Registry System 5'-Adenylic acid (61-19-8)   Safety Information Safety Statements  24/25 WGK Germany  3 RTECS  AU7480500 TSCA  Yes HS Code  29389090 Hazardous Substances Data 61-19-8(Hazardous Substances Data) Toxicity LD50 intraperitoneal in mouse: 4gm/kg MSDS Information Provider Language 5'-Adenylic acid English SigmaAldrich English ACROS English   Adenosine 5'-monophosphate Usage And Synthesis Chemical Properties White crystalline powder. Melting point: 196-200°C (decomposition). Specific optical rotation:-47.5° (20°C, 2% in sodium hydroxide (2%)). Soluble in water, slightly soluble in alcohol, insoluble in ether. Applications Clinically it is used to treat disseminated sclerosis, porphyria, itching, liver disease, varicose ulcer complication. Eye drops with denosine monophosphate as the main component can be used to treat eye fatigue, central amphiblestitis, ocular pannus,  herpes and other corneal surface diseases. Intramuscular injection shows local erythema, generalized essential telangiectasia, red face, dizziness, breathing difficulty and palpitation. As nutrition enhancer; as intermediate to produce nucleotide drugs; as food additive; as biological products; as dietary supplement and biochemical reagent. It is used to produce adenosine triphosphate (ATP), cyclic adenylate (cAMP) and other biochemical drugs. It is a type of nucleotide products and to produce antiviral drugs, synthetic energy drugs and cardiovascular and cerebrovascular drugs, such as adenosine, ATP, 3 '-5'-cyclic adenosine monophosphate. Preparation Candida utilis fungi is treated with hot water to obtain nucleic acids, which is hydrolyzed by enzymes and separated to obtain the final product. Take mycelia as the raw material: Subtraction and sedimentation of mycelia are carried out with 3 times amount of water. Industry base is added to reach a base concentration of 0.25% (g/100mL). After stirring for 1 hours, 20% sulfuric acid is added until the PH value is 7. The solution is filtrated and the pH value of filtrate is adjusted with 20% sulfuric acid to 2.5. Centrifugation is then applied to obtain nucleic acid mud. mycelia [sodium hydroxide]→[1h] extract solution [20% sulfuric acid] → [pH=7, filtration] filtrate [20% sulfuric acid] →[pH=2.5, centrifugation] nucleic acid mud 1% nucleic acid solution is made by subsequent dissolution, enzymolysis, absorption and elution. 10% ammonia water is then used to adjust the pH value to 6-6.2. Then the mixture is heated at 90°C for 20 min and cooled. After centrifugation, the supernatant is heated up to 65-70°C and added with 1/3 phosphodiesterase solution. After 2 hours, the temperature is raised to 90°C.  10min later, it is cooled to room temperature. 20% sulfuric acid is added to adjust the pH value to 2.5-3. After filtration, the filtrate is adjusted with ammonia solution until the pH=7.2-7.5. 0.3% (3 g/L) diatomite is then added to assist the filtration. The corresponding supernatant is filtered with an anion exchange resin column (717-type) and eluted with 0.05 mol/L sulfuric acid. Afterwards, absorption, elution and crystallization are carried out. The detailed procedures of these three steps are: The eluate is first absorbed with a cation exchange column (732-type) and eluted with distilled water (pH=1.5). The collection of eluate starts when the eluate turned red with bromine water. The eluate is then concentrated to 80-90 mg/mL under reduced pressure, added with diatomite and stirred for 30 min before filtration. The filtrate is adjusted with 6 mol/L hydrochloric acid till pH=2.5. To realize full crystallization, the filtrate is cooled during stirring. After followed filtration, it is washed with dry ethanol for 3 times. Vacuum drying at 60°C is applied to obtain the final AMP products. Nucleic acid mud [ammonia gas] →[pH=6-6.2, 90°C, 20min] supernatant [phosphodiesterase] →[65-70°C,2h,] hydrolysis solution [717 resin] →absorbent [sulfuric acid] →elution solution [732 resin] →AMP, CMP, GMP absorbent mixtures. Usage restriction GB 2760-2001：infant formula milk powder 0.2~0.58 g/kg (based on the total amount of nucleotide) Category Toxic substance Toxicity Grading Middle toxicity Acute Toxicity Peritoneal-mouse LD50: 4000 mg/kg Flammability Hazardous Characteristics Flammable; generation of toxic nitrogen oxides and phosphorous oxide smoke when heated. Storage and Transport Stored in well ventilated area, low temperature, and dry. Extinguishing Agent Dry powder, foam, sand, carbon dioxide. Chemical Properties colorless to white crystalline powder Uses antiasthmatic Uses vasodilator, neuromodulator Uses Adenosine 5'-Monophosphate is a natural occurring nucleotide and a useful ligand determinant that facilitate the binding of APS reductase inhibitors and activates adenosine receptor agonists. Uses A useful ligand determinant that facilitates the binding of APS reductase inhibitors. Uses Adenosine 5'-monophosphate is a nucleotide (building blocks of nucleic acid) added to skin care products to bind water and moisture. Definition ChEBI: A purine ribonucleoside 5'-monophosphate having adenine as the nucleobase. Brand name Adenyl (Wyeth-Ayerst); My-BDen (Bayer. Safety Profile Slightly toxic by intraperitoneal route. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of PO, and NOx.   Adenosine 5'-monophosphate Preparation Products And Raw materials Raw materials Government regulation-->FUMING SULFURIC ACID-->4-Chlorobenzaldehyde-->Celite-->Ribonucleic acid-->Yeast extract-->ANION EXCHANGE RESIN 717-->Sodium selenite-->PHOSPHODIESTERASE I-->6-amino-9-[3-hydroxy-5-[(hydroxy-sulfooxy-phosphoryl)oxymethyl]-4-phosphonooxy-oxolan-2-yl]-purine-->ADP Preparation Products 6-Thioguanine-->Disodium 5'-Inosinate-->Vidarabine-->β-D-Ribofuranose, 5-(dihydrogen phosphate)-->PHOSPHATE STANDARD

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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