China Biggest Manufacturer factory sales Furaneol CAS 3658-77-3

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Furaneol Basic information Product Name: Furaneol Synonyms: CARMELAN;FEMA 3174;FURANEOL;HYDROXY DIMETHYL FURANONE;4-HYDROXY-2,5-DIMETHYL-3(2H)-FURANONE;4-HYDROXY-2,5-DIMETHYLFURAN-3(2H)-ONE;4-HYDROXY-2,5-DIMETHYL-FURAN-3-ONE;2,5-DIMETHYL-4-HYDROXY-2,3-DIHYDROFURAN-3-ONE CAS: 3658-77-3 MF: C6H8O3 MW: 128.13 EINECS: 222-908-8 Product Categories: API intermediates;Furan flavors;Furan&Benzofuran;Alphabetical Listings;C-D;Flavors and Fragrances Mol File: 3658-77-3.mol   Furaneol Chemical Properties Melting point  73-77 °C(lit.) Boiling point  188 °C density  1.049 g/mL at 25 °C FEMA  3174 | 4-HYDROXY-2,5-DIMETHYL-3(2H)-FURANONE refractive index  n20/D 1.439 Fp  >230 °F storage temp.  2-8°C solubility  Chloroform (Slightly), Methanol (Slightly) pka 9.62±0.40(Predicted) form  neat color  White JECFA Number 1446 BRN  1281357 Stability: Light Sensitive, Temperature Sensitive InChIKey INAXVXBDKKUCGI-UHFFFAOYSA-N CAS DataBase Reference 3658-77-3(CAS DataBase Reference) NIST Chemistry Reference 2,5-Dimethyl-4-hydroxy-3(2h)-furanone(3658-77-3) EPA Substance Registry System 4-Hydroxy-2,5-dimethyl-3(2H)furanone (3658-77-3)   Safety Information Hazard Codes  Xn Risk Statements  22 Safety Statements  36-24/25 WGK Germany  3 RTECS  LU3990000 F  10-23 HS Code  29321900 Hazardous Substances Data 3658-77-3(Hazardous Substances Data) MSDS Information Provider Language 2,5-Dimethyl-4-hydroxy-3[2H]-furanone English SigmaAldrich English ACROS English   Furaneol Usage And Synthesis Description Furaneol is a very important aroma chemical and is a key flavoring compound found in many kinds of fruits. It can be chemically formed through different carbohydrates during the Mainlard reaction. It can also be synthesized by yeast, bacteria and plants and play some physiological effects. Study has shown that it can suppress the phosphorylation of cAMP response element binding protein, underlying its potential role as an effective inhibitor of hyperpigmentation. It also has the potential to become an effective antimicrobial agent for human beings. Chemical Properties Furaneol is a constituent of pineapple and strawberry aroma and is also found in other foods. It forms colorless crystals (mp 77–79°C) with a relatively weak, nonspecific odor. Dilute solutions develop a pineapple, strawberrylike odor. Chemical Properties white to light yellow crystal powde Chemical Properties 4-Hydroxy-2,5-dimethyl-3(2H)-furanone has a fruity caramel or "burnt pineapple" aroma. May be synthesized from dimethyl- 3,4-dihyroxyfuran-2,5-dicarboxylate. Chemical Properties Furaneol has a sweet, fruity, strawberry, hot sugar, fruity caramel or “burnt pineapple” aroma. Occurrence Reported found in guava, grapes, pineapple, raspberry, strawberry fruit and jam, rye bread, Swiss cheese, boiled beef, beer, cocoa, coffee, tea, filberts, almonds, oatmeal, Arctic bramble, yellow passion fruit, mango, shoyu, fermented soy sauce, litchi, malt and Cape gooseberry. Uses 2,5-Dimethyl-4-hydroxy-3(2H)-furanone is a component of meat essence composition. 2,5-Dimethyl-4-hydroxy-3(2H)-furanone is used in the flavor and perfume industry due to its sweet strawberry aroma. Definition ChEBI: A member of the class of furans that is 2,5-dimethylfuran carrying additional oxo and hydroxy groups at positions 3 and 4 respectively. It has been found particularly in strawberries and other such fruits. Preparation Furaneol can be prepared by cyclization of hexane-2,5-diol-3,4-dione in the presence of an acidic catalyst.The dione is the ozonization product of 2,5- hexynediol, which is obtained by ethynylation of acetaldehyde. In another process, a dialkyl -methyldiglycolate (formed from an alkyl lactate and an alkyl monochloroacetate) is reacted with dialkyl oxalate in the presence of a sodium alkoxide and dimethylformamide. The reaction product is cyclized, alkylated, hydrolyzed, and decarboxylated.In another process, a dialkyl -methyldiglycolate (formed from an alkyl lactate and an alkyl monochloroacetate) is reacted with dialkyl oxalate in the presence of a sodium alkoxide and dimethylformamide. The reaction product is cyclized, alkylated, hydrolyzed, and decarboxylated . Aroma threshold values Detection: 0.03 to 60 ppb; aroma characteristics at 0.1%: sweet, slightly burnt brown caramellic, cotton candy with a savory nuance Taste threshold values Taste characteristics at 0.10 to 1.0 ppm: sweet caramellic cooked meaty and fruity nuances Synthesis Reference(s) The Journal of Organic Chemistry, 57, p. 5023, 1992 DOI: 10.1021/jo00044a047 Synthesis, p. 377, 1987 General Description 4-Hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF, DMHF) is a caramel-like smelling compound, identified in Maillard reaction systems based on pentoses by GC-MS and GCMS/MS. Solubility data of DMHF in six different solvents over the temperature range from 283.15K to 313.15K under atmospheric pressure of 0.10 MPa has been examined by dynamic method. Separation of the enantiomers of DMHF by capillary electrophoretic method has been reported. Commercially it is synthesized from L-rhamnose. DMHF has been identified as acidic odorant in Thai premium fish sauce samples by aroma extract dilution analysis (AEDA). It is identified as key aroma compound in the distiller′s grains (DG) from wheat. It is reported as the main flavor compound in strawberries and its biosynthesis has been reported. HDMF has been found in various fruits such as pineapples strawberries and grapes, as well as in beef broth , roasted coffee, bread crust, roasted beef, roasted sesame seeds and stewed beef. Trade name Furaneol® (Firmenich). Biochem/physiol Actions Taste at 0.10 to 1.0 ppm Chemical Synthesis From dimethyl-3,4-dihydroxyfuran-2,5-dicarboxylate References Pickenhagen, Wilhelm, et al. "Estimation of 2,5-dimethyl-4-hydroxy-3(2H)-furanone (FURANEOLA®) in cultivated and wild strawberries, pineapples and mangoes." Journal of the Science of Food & Agriculture 32.11(2010):1132-1134. Farine, Jean Pierre, et al. "4-Hydroxy-5-methyl-3(2H)-furanone and 4-Hydroxy-2,5-dimethyl-3(2H)-furanone, Two Components of the Male Sex Pheromone of Eurycotis floridana (Walker) (Insecta, Blattidae, Polyzosteriinae)." Bioscience Biotechnology & Biochemistry 57.12(2014):2026-2030. Schwab, W. "Natural 4-hydroxy-2,5-dimethyl-3(2H)-furanone (Furaneol®). " Molecules 18.6(2013):6936-51.   Furaneol Preparation Products And Raw materials Raw materials Propylene glycol-->Ethyl lactate-->Crotononitrile (pract)-->4-Hydroxy-5-methyl-3-furanone Preparation Products 4-Methoxy-2,5-dimethyl-3(2H)-furanone

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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