China Biggest Manufacturer factory sales Diosgenin CAS 512-04-9

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Diosgenin Basic information Product Name: Diosgenin Synonyms: Diosgemom;DIOCTYLMALONATE;DIOSGENIN (3B-HYDROXY-5A-SPIROSCENE);20F,22F-Spirosten-3-ol;22alpha-Spirost-5-en-3beta-ol;25d-Spirost-5-en-3b-ol;5-22-Spirosten-3-ol;5-25D-Spirosten-3-ol CAS: 512-04-9 MF: C27H42O3 MW: 414.63 EINECS: 208-134-3 Product Categories: Plant extracts;Herb extract;Biochemistry;Steroids;Steroids (Others);The group of Dioscin;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Pharmaceutical Intermediates;FINE Chemical & INTERMEDIATES;API;reference substance;Plant extract;Inhibitors Mol File: 512-04-9.mol   Diosgenin Chemical Properties Melting point  205-208°C alpha  D25 -129° (c = 1.4 in CHCl3) Boiling point  473.46°C (rough estimate) density  1.0483 (rough estimate) refractive index  1.4700 (estimate) storage temp.  2-8°C solubility  chloroform: 20 mg/mL, clear, slightly yellow pka 15.02±0.70(Predicted) form  Solid color  White to Pale Yellow Water Solubility  Soluble in chloroform (50 mg/ml), ethanol (83 mg/ml at 25°C), water (<1 mg/ml at 25°C), DMSO (<1 mg/ml at 25°C), and methanol. Merck  14,3295 BRN  94582 CAS DataBase Reference 512-04-9(CAS DataBase Reference) NIST Chemistry Reference Diosgenin(512-04-9)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36/37-24/25 WGK Germany  2 RTECS  WH1450000 HS Code  29329990 MSDS Information Provider Language (25R)-Spirost-5-en-3beta-ol English SigmaAldrich English   Diosgenin Usage And Synthesis Chemical Properties White to Off-White Dolid Uses antiinflammatory, estrogen Uses Aglicone of saponin dioscin. Diosgenin exists in some food supplements and herbal medicines and lowers plasma cholesterol by increasing fecal cholesterol excretion. e and Progesterone. Uses pregnenolone and progesterone precursor General Description Diosgenin is a triterpene and a glycone derivative of dioscin. Yams, Trigonella foenum-graecum and Costus speciosus are some of its source. Biochem/physiol Actions Diosgenin induces apoptosis in colon cancer cell lines and induces apoptosis, cell cycle arrest and cyclooxygenase activity in osteosarcoma cells. It serves as a precursor in steroid drug production. Diosgenin is shown to promote cholesterol production by stimulating biliary excretion. It influences lipoxygenase induced human erythroleukemia cell line differentiation. Anticancer Research It is a steroidal saponin and legumes and yams are the rich sources of it. It is a notoriousprecursor of several synthetic steroidal drugs. It suppresses growth of cells andinduces apoptosis in human osteosarcoma, colon cancer, and leukemia. Its anticancermechanism is by arresting the cell cycle, disrupting the calcium homeostasis,activating p53, releasing apoptosis inducing factors, and modulating caspase-3activity. It suppresses NF-κB activation induced by TNF as a result of DNA binding,IκBα kinase activation, degradation, phosphorylation, p65 nuclear translocation,and phosphorylation. It suppresses proliferation and invasion and induces apoptosisby downregulation of cFLIP, cyclin-D1, TRAF1, COX-2, c-myc, Bfl-1/A1, BclxL,IAP1, Bcl-2, and MMP-9 (Aggarwal et al. 2008; Raju and Mehta 2008). Purification Methods Crystallise diosgenin from acetone, and chromatograph it on Al2O3 and elute with *C6H6/Et2O (9:1), then recrystallise it from MeOH. Its solubility is ~4% in H2O and 5% in CHCl3. The acetate crystallises from AcOH with m 198o; and has [] D 20 -119o (pyridine). [Marker et al. J Am Chem Soc 65 1199 1943. Mazur et al. J Am Chem Soc 82 5889 1960, Beilstein 19 IV 862.]   Diosgenin Preparation Products And Raw materials Preparation Products 16-Dehydropregnenolone acetate-->16a,17a-Epoxyprogesterone-->Hydroxyprogesterone-->17-Hydroxy-21-iodoprogesterone-->16-Bromo-17-hydroxypregn-4-en-3,20-dione-->11a-Hydroxy-16,17a-epoxyprogesterone-->21-DEOXYCORTISONE-->16,17-Epoxypregnenolone-->16,17-Epoxypregn-4-ene-3,11,20-trione-->REICHSTEIN'S SUBSTANCE S 21-ACETATE

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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