China Biggest Manufacturer factory sales Indole-2-carboxylic acid CAS 1477-50-5

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Indole-2-carboxylic acid Basic information Product Name: Indole-2-carboxylic acid Synonyms: NSC 16598;Indole-2-carboxylic;Indole-2-earboxylic acid ethylester;INDOLE-2-CARBOXYLIC ACID(I2CA);Indole-2-carboxylic acid,99%;Indole-2-carboxylic acid 　 Indole-2-carboxylic acid;Indole-2-carboxylacid;1H-Indole-2-carboxylic acid 98% CAS: 1477-50-5 MF: C9H7NO2 MW: 161.16 EINECS: 216-030-4 Product Categories: Simple Indoles;Amino Acids & Derivatives;Carboxylic Acids;Indole Derivatives;Carboxylic Acids;Pyrroles & Indoles;Indole/indoline/oxindole;indole derivative;Indole and Indoline;Pyrroles & Indoles;Indole;Organic acids;Amino Acids 13C, 2H, 15N;Indoles;Indoles and derivatives;Bioactive Small Molecules;Building Blocks;C7 to C9;Cell Biology;Chemical Synthesis;Heterocyclic Building Blocks;I;Heterocycle-Indole series;commercial Mol File: 1477-50-5.mol   Indole-2-carboxylic acid Chemical Properties Melting point  202-206 °C(lit.) Boiling point  287.44°C (rough estimate) density  1.2480 (rough estimate) refractive index  1.5050 (estimate) storage temp.  Keep in dark place,Sealed in dry,Room Temperature solubility  Soluble in clear yellow solution 5% in ethanol, dimethyl sulfoxide and methanol. form  Crystalline Powder or Crystals pka 4.44±0.30(Predicted) color  Off-white to yellow to brown BRN  124132 CAS DataBase Reference 1477-50-5(CAS DataBase Reference) NIST Chemistry Reference Indole-2-carboxylic acid(1477-50-5)   Safety Information Hazard Codes  Xn,Xi Risk Statements  36/37/38-21/22 Safety Statements  22-24/25 WGK Germany  3 RTECS  NK7882812 Hazard Note  Irritant HazardClass  IRRITANT HS Code  29339990 MSDS Information Provider Language Indole-2-carboxylic acid English SigmaAldrich English ACROS English ALFA English   Indole-2-carboxylic acid Usage And Synthesis Chemical Properties Yellow Crystalline Powder Uses • ;Reactant for total synthesis of (±)-dibromophakellin and analogs1• ;Reactant for synthesis of the pyrrolizidine alkaloid (±)-trachelanthamidine2• ;Reactant for stereoselective preparation of renieramycin G analogs3• ;Reactant for preparation of spirooxoindolepyrrolidines via reduction of indole-2-carboxylic acid followed by oxidation, condensation, reduction, amidation and Kharasch radical cyclization4• ;Reactant for Pd-catalyzed cyclization5• ;Reactant for preparation of N,N′-(pentane)diylbis[indolecarboxamide] and N,N′-[phenylenebis( Uses Reactant for total synthesis of (±)-dibromophakellin and analogs, synthesis of the pyrrolizidine alkaloid (±)-trachelanthamidine, stereo selective preparation of renieramycin G analogs, preparation of spirooxoindolepyrrolidines via reduction of indole-2-carboxylic acid followed by oxidation, condensation, reduction, amidation and Kharasch radical cyclization, Pd-catalyzed cyclization and N,N -(pentane)diylbis[indolecarboxamide] and N,N -[phenylenebis(methylene)]bis[indolecarboxamide] derivatives. Synthesis Reference(s) Tetrahedron Letters, 33, p. 7961, 1992 DOI: 10.1016/S0040-4039(00)74789-7   Indole-2-carboxylic acid Preparation Products And Raw materials Raw materials 3-Indoleformic acid-->ethyl 3-(o-nitrophenyl)pyruvate-->2-BROMO-1H-INDOLE-->Ethyl indole-2-carboxylate Preparation Products Methyl 1H-indole-2-carboxylate-->3-Indolepropionic acid-->Indoline-2-carboxylic acid-->3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID-->1H-INDOL-2-YLMETHANOL

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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